|Module code||BCM 357|
|Faculty||Faculty of Natural and Agricultural Sciences|
Regulation of metabolic pathways. Analysis of metabolic control. Elucidation of metabolic pathways with isotopes. Metabolomics. Coordinated regulation of glycolysis/gluconeogenesis and glycogen breakdown/synthesis. Enzyme defects in metabolism and consequences. Hormonal regulation and integration of mammalian metabolism. Regulation of fuel metabolism after a meal, period between meals and starvation. Metabolic adaptions during diabetes. Obesity and the regulation of body mass. Obesity, metabolic syndrome and Type 2 diabetes (T2D). Management of T2D with diet, exercise and medication. Practical sessions cover tutorials on case studies and biochemical calculations, isolation of an enzyme, determination of pH and temperature optima, determination of Km and Vmax, enzyme activation and enzyme inhibition.
|Prerequisites||BCM 251 GS and BCM 252 GS and BCM 261 GS.|
|Contact time||1 practical/tutorial per week, 2 lectures per week|
|Language of tuition||Module is presented in English|
|Department||Biochemistry, Genetics and Microbiology|
|Period of presentation||Semester 1|
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