Umbiflow

Detection and prevention of stillbirths 

The detection and prevention of fetuses at risk for stillbirth; specifically, those not detected by traditional means using a continuous-wave Doppler ultrasound, an Umbiflow. A pilot study has been established in 9 sites in South Africa. The project has been extended to 5 African countries as Umbiflow international.

The development of Umbiflow was funded by the Council for Scientific Research (CSIR) and The South African Medical Research Council (SAMRC). It is also the result of a successful collaboration between the Gauteng, Western Cape, and National departments of health.

An initial study conducted by SAMRC and the University of Pretoria’s Maternal and Infant Health Care Strategies Unit in Mamelodi, Pretoria, revealed that the device reduced the perinatal mortality rate in the study group by over 50% when compared to the control group.

 

UmbiBaby

The UmbiBaby study followed up 91 infants from the Umbiflow International Study, which uses the innovative low-cost Umbiflow device to screen for in utero growth restriction due to placental insufficiency, which is thought to be one of the major causes of stillbirths in low- and middle-income countries.

In the UmbiBaby study, infants were followed up over 8-time points in the first two years of life postpartum. Infants who had been identified within utero growth restriction (abnormal Doppler values) from the Umbiflow International study will be compared to infants who had a normal Doppler in utero from the same study. The main outcomes of the UmbiBaby study are the infant’s growth, body composition and neurological development and it is envisaged that the study will provide valuable information on the management of growth-restricted infants postpartum, who before Umbiflow screening may have been stillbirths.

In the UmbiBaby study, infants who have been identified within utero growth restriction from the Umbiflow International study will be compared with premature and healthy full-term infants from the same study over the first year of life postpartum. The main outcomes of the UmbiBaby study will be the infant’s growth, body composition and neurological development and it is envisaged that the study will provide valuable information on the management of growth-restricted infants postpartum, who before Umbiflow screening may have been stillbirths.

UmbiGodisa

The UmbiGodisa study aims to recruit a total of 300 infants from the Umbiflow International Study at a single time point of 18 months. The main objective of this larger cross-sectional study is to evaluate the dual burden of abnormal Doppler values in utero and maternal HIV infection on infant outcomes, such as infant growth, body composition and neurodevelopment. 

Investigators

Sponsors

  • Umbiflow SA: SAMRC & CSIR
  • Umbiflow International: WHO

Publications

Vannevel V, Vogel JP, Pattinson RC, Adanu R, Charantimath U, Goudar SS, Gwako G, Kavi A, Maya E, Osoti A, Pujar Y. Antenatal Doppler screening for fetuses at risk of adverse outcomes: a multicountry cohort study of the prevalence of abnormal resistance index in low-risk pregnant women. BMJ open. 2022 Mar 1;12(3):e053622.DOI: https://bmjopen.bmj.com/content/12/3/e053622

Hlongwane TM, Cronje T, Nkosi BS, Pattinson RC. The prevalence of abnormal Doppler's of the umbilical artery in a low-risk pregnant population in South Africa. EClinicalMedicine. 2021 Mar 18:100792. DOI: https://doi.org/10.1016/j.eclinm.2021.100792

Vogel JP, Vannevel V, Robbers G, Gwako G, Lavin T, Adanikin A, Hlongwane T, Pattinson RC, Qureshi ZP, Oladapo OT. Prevalence of abnormal umbilical arterial flow on Doppler ultrasound in low-risk and unselected pregnant women: a systematic review. Reproductive health. 2021 Dec;18(1):1-7. DOI: https://link.springer.com/article/10.1186/s12978-021-01088-w

Mueller D, Pattinson RC, Hlongwane TM, Busse R, Panteli D. Portable continuous wave Doppler ultrasound for primary healthcare in South Africa: can the EUnetHTA Core Model guide evaluation before technology adoption? Cost-Effectiveness and Resource Allocation. 2021 Dec;19(1):1-6. DOI: https://resource-allocation.biomedcentral.com/articles/10.1186/s12962-021-00261-z

Hlongwane TM, Bozkurt B, Barreix MC, Pattinson R, Gülmezoglu M, Vannevel V, Tunçalp Ö. Implementing antenatal care recommendations, South Africa. Bull World Health Organ. 2021 Mar 1;99(3):220-227. DOI: 10.2471/BLT.20.278945. Epub 2021 Jan 21. PMID: 33716344; PMCID: PMC7941100.
DOI: https://doi.org/10.2471/BLT.20.278945 

Pattinson RC, Hlongwane TM, Busse R, Panteli D. Portable continuous wave Doppler ultrasound for primary healthcare in South Africa: can the EUnetHTA Core Model guide evaluation before technology adoption?. DOI: https://assets.researchsquare.com/files/rs-81497/v1/ed9fc891-1f21-4ba9-9760-44dc2f16093d.pdf

Vannevel V, Robbers G, Gwako G, Lavin T, Adanikin A, Hlongwane T, Pattinson RC, Qureshi ZP, Oladapo OT. Prevalence of Abnormal Umbilical Arterial Flow on Doppler Ultrasound in Low-risk and Unselected Pregnant Women: A Systematic Review. DOI: https://assets.researchsquare.com/files/rs-96851/v1/994233c4-26d4-4dd2-b762-9a200ea0eb0c.pdf 

Dornan JC, Feucht U, Dornan SS, Mulol H, Vannevel V, Hlongwane T, Pattinson R (2021) Continuous-wave Doppler, fetal growth restriction and small for gestational age babies. BJOG, 128;5:940. DOI: https://doi.org/10.1111/1471-0528.16643

Feucht U, Mulol H, Vannevel V, Pattinson R (2021). The ability of continuous-wave Doppler ultrasound to detect fetal growth restriction. PLOS One, 16(8):1-14. DOI: https://doi.org/10.1371/journal.pone.0255960 

Media articles

Brochures 

CSIR- UMBIflowDevice

Umbiflow brochure

Videos

- Author Cathy Bezuidenhout
Published by Sanele Mntla

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