2025

Ishmail F-Z, Coertzen D, Tshabalala S, Leshabane M, da Rocha S, Njoroge M, et al. Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity. ACS Medicinal Chemistry Letters. 2025; 16(3):428-35. doi:10.1021/acsmedchemlett.4c00545

Maharaj R, Abdelatif N, Maquina M, Seocharan I, Lakan V, Paaijmans K, et al. The epidemiology of malaria in four districts in southern Mozambique receiving indoor residual spray as part of a cross-border initiative. Malaria Journal. 2025; 24(1):22. doi:10.1186/s12936-025-05258-0

2024

Banasiak J, Tchoumi SY. Multiscale malaria models and their uniform in-time asymptotic analysis. Math Comput Simul. 2024; 221:1–18. doi:10.1016/j.matcom.2024.02.015

Belay AK, Asale A, Sole CL, Yusuf AA, Torto B, Mutero CM, Tchouassi DP. Feeding habits and malaria parasite infection of Anopheles mosquitoes in selected agroecological areas of Northwestern Ethiopia. Parasit Vectors. 2024; 17:412. doi:10.1186/s13071-024-06496-y

Belay AK, Asale A, Sole CL, Kinya F, Yusuf AA, Torto B, Mutero CM, Tchouassi DP. Vectorial drivers of malaria transmission in Jabi Tehnan district, Amhara Regional State, Ethiopia. Scientific Reports. 2024; 14:13669. doi:10.1038/s41598-024-64436-3

Dada N, Simpson VJ, Amenga-Etego LN, Oriero E, Miotto O, Torok ME, Juma EO, Williams NA, Rajatileka S, Ariani CV, Raman J, Ishengoma DS. Towards integrated malaria molecular surveillance in Africa. Trends Parasitol. 2024; 40(11):964-969. doi:10.1016/j.pt.2024.09.005.

Davis B, Eskenazi B, Bornman R, Obida M, Chevrier J. Association between prenatal exposure to indoor residual spraying insecticides and infection rates among South African children participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE). Sci Total Environ. 2024; 918:170483. doi:10.1016/j.scitotenv.2024.170483

Elsiwi B, Eskenazi B, Bornman R, Obida M, Kim J, Moodie EE, Mann KK, Chevrier J. Maternal exposure to pyrethroid insecticides during pregnancy and respiratory allergy symptoms among children participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE). Environ Res. 2024; 242:117604. doi:10.1016/j.envres.2023.117604

Dziwornu GA, Seanego D, Fienberg S, Clements M, Ferreira J, Sypu VS, Samanta S, Bhana AD, Korkor CM, Garnie LF, Teixeira N, Wicht KJ, Taylor D, Olckers R, Njoroge M, Gibhard L, Salomane N, Wittlin S, Mahato R, Chakraborty A, Sevilleno N, Coyle R, Lee MCS, Godoy LC, Pasaje CF, Niles JC, Reader J, van der Watt M, Birkholtz L-M, Bolscher JM, de Bruijni MHC, Coulson LB, Basarab GS, Ghorpade SR, Chibale K. 2,8-Disubstituted-1,5-naphthyridines as dual inhibitors of Plasmodium falciparum phosphatidylinositol-4-kinase and hemozoin formation with in vivo efficacy. J. Med. Chem. 2024; 67. doi:10.1021/acs.jmedchem.4c01154

Gomez-Gonzalez PJ, Gupta A, Drought LG, Patel A, Okombo J, van der Watt M, Walker-Gray R, Schindler KA, Burkhard AY, Yeo T, Narwal SK. Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Sci Adv. 2024; 10(49):eadq1383.

Greyling N, van der Watt M, Gwarinda H, van Heerden A, Greenhouse B, Leroy D, Niemand J, Birkholtz L. Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates. Antimicrob Agents Chemother. 2024; e01291-23. doi:10.1128/aac.01291-23

Kleinhans I, Mahanjana S, Els F, Mabona M, Pitso LA, Malatje G, Kok G, Raman J. The prevalence and distribution of malaria in Mpumalanga Province before and during COVID-19 (2017 - 2022). S Afr Med J. 2024; 114(8):e1736. doi:10.7196/SAMJ.2024.v114i8.1736

Lismer A, Shao X,Dumargne MC, Lafleur C, Lambrot R, Chan D, Toft G, Bonde JP, MacFarlane AJ, Bornman R, Aneck-Hahn N, Patrick S, Bailey JM, de Jager C, Dumeaux V, Trasler JM, Kimmins S. The association between long-term DDT or DDE exposures and an altered sperm epigenome – a cross-sectional study of Greenlandic Inuit and South African Vhavenda men. Environ Health Perspect. 2024; 132(1):017008-1– 24. doi:10.1101/2022.08.15.504029

Mabona M, Baloyi RE, Shandukani MB, Mogadime M, Wanjala S, Raman J. A review of malaria trends in South Africa for the 2022-2023 malaria season based on the Notifiable Medical Conditions surveillance system. Public Health Bulletin South Africa. 2024; https://www.phbsa.ac.za/wp-content/uploads/2024/04/Malaria-NMC-surveillance-report-2022-23.pdf 

Mabona M, Zwane T, Raman J, Kuonza L, Mhlongo B, Phafane P. Evaluation of the malaria case surveillance system in KwaZulu-Natal Province, South Africa, 2022: a focus on DHIS2. Malar J. 2024; 23(1):47. doi:10.1186/s12936-024-04873-7

Mambwe D, Coertzen D, Leshabane M, Mulubwa M, Njoroge M, Gibhard L, Girling G, Wicht KJ, Lee MC, Wittlin S, Moreira DRM, Birkholtz L, Chibale K. hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole. ACS Med Chem Lett. 2024; 15. doi:10.1021/acsmedchemlett.3c00496

Mbaba M, Golding TM, Omondi RO, Mohunlal R, Egan TJ, Reader J, Birkholtz L-M, Smith GS. Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration. Eur J Med Chem. 2024; 271. doi:10.1016/j.ejmech.2024.116429

Naude M, van Heerden A, Reader J, van der Watt M, Niemand J, Joubert D, Siciliano G, Alano P, Njoroge M, Chibale K, Herreros E, Leroy D, Birkholtz L-M. Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials. Nat Commun. 2024; 15:9896. doi:10.1038/s41467-024-54144-x

Ouifki R, Banasiak J, Tchoumi SY. The impact of demography in a model of malaria with transmission-blocking drugs. Math. Meth. Appl. Sci. 2024;1–29. doi: 10.1002/mma.10091

Raman, J, Frean J. The management of malaria in South Africa. Infectious Diseases Update. 2024 13(3):6-8.

Saili K, de Jager C, Masaninga F, Sangoro OP, Nkya TE, Likulunga LE, Chirwa J, Hamainza B, Chanda E, Fillinger U, Mutero CM. House screening reduces exposure to indoor host-seeking and biting malaria vectors: evidence from rural South-East Zambia. Trop Med Infect Dis. 2024; 9(20):1-16. doi:10.3390/tropicalmed9010020

Xie SC, Tai CW, Morton CJ, Ma L, Huang SC, Wittlin S, Du Y, Hu Y, Dogovski C, Salimimarand M, Griffin R, England D, de la Cruz E, Deni I, Yeo T, Burkhard AY, Striepen J, Schindler KA, Crespo B, Gamo FJ, Khandokar Y, Hutton CA, Rabie T, Birkholtz L-M, Famodimu MT, Delves MJ, Bolsher J, Koolen KMJ, van der Laak R, Aguiar ACC, Pereira DB, Guido RVC, Creek DJ, Fidock DA, Dick LR, Brand SL, Gould AE, Langston S, Griffin MDW, Tilley L. A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. PLoS Pathog. 2024; 20(12):e1012429. doi:10.1371/journal.ppat.1012429 

Watson SJ, van der Watt ME, Theron A, Reader J, Tshabalala S, Erlank E, Koekemoer LL, Naude M, Stampolaki M, Adewole F, Sadowska K, Pérez-Lozano P, Turcu AL, Vázquez S, Ko J, Mazurek B, Singh D, Malwal SR, Njoroge M, Chibale K, Onajole OK, Kolocouris A, Oldfield E, Birkholtz L. The tuberculosis drug candidate SQ109 and its analogs have multistage activity against Plasmodium falciparum. ACS Infect. Dis. 2024; 10:3358−3367. doi:10.1021/acsinfecdis.4c00461

Wooding M, Dodgen T, Rohwer ER, Naudé Y. Advancing the analytical toolkit in the investigation of vector mosquito host biting site selection. J Mass Spectrom. 2024; 59:e4992.

Banasiak J. Introduction to Mathematical Methods in Population Theory: Springer Cham; 2024.  doi:https://link.springer.com/book/10.1007/978-3-031-65491-6

2023

Chisanga B, Bulte E, Kassie M, Mutero C, Masaninga F, Sangoro OP. The economic impacts of house screening against malaria transmission: Experimental evidence from eastern Zambia. Soc Sci Med [Internet]. 2023;321:115778. doi:org/10.1016/j.socscimed.2023.115778

Danquah BA, Chirove F, Banasiak J. Controlling malaria in a population accessing counterfeit antimalarial drugs. Mathematical Biosciences and Engineering. 2023;20(7):11895-938. doi:10.3934/mbe.2023529

Dieng S, Adebayo-Ojo TC, Kruger T, Riddin M, Trehard H, Tumelero S, Bendiane MK, de Jager C, Patrick S, Bornman R, Gaudart J. Geo-epidemiology of malaria incidence in the Vhembe District to guide targeted elimination strategies, South-Africa, 2015–2018: a local resurgence. Sci Rep. 2023;13(1):11049. doi:org/10.1038/s41598-023-38147-0

Gwarinda HB, Tessema SK, Raman J, Greenhouse B, Birkholtz LM. Population structure and genetic connectivity of Plasmodium falciparum in pre-elimination settings of Southern Africa. Frontiers in Epidemiology. 2023;3. doi:org/10.3389/fepid.2023.1227071

Kollipara A, Moonasar D, Balawanthd R, Silal SP, Yuen A, Foxa K, Njau J, Pillay, YG, Bleche M. Mobilizing resources with an investment case to mitigate cross-border malaria transmission and achieve malaria elimination in South Africa. Global Health Action. 2023;16(1):2205700. doi:org/10.1080/16549716.2023.2205700

Maharaj R, Ward A, Didier B, Seocharan I, Firas N, Balawanth R, Lucero D, Morris N, Shandukani M, Raswiswi E, Malatjie G, Mabunda E, Moonasar D. The effect of the COVID-19 lockdown on malaria transmission in South Africa. Malaria Journal. 2023;22(1):107. doi:org/10.1186/s12936-023-04542-1

Mianda SM, Moyo P, Maboane S, Birkholtz LM, Maharaj VJ. Phytoconstituents from Turraea obtusifolia and their antiplasmodial activity. Natural Product Research.1-13. doi:org.uplib.idm.oclc.org/10.1080/14786419.2023.2255921

Moyo DS, van der Merwe EM, Rademeyer M, Malan FP, Atanasova MT, Mapossa AB, Focke WW. Characterizing the thermal phase behaviour of fipronil polymorphs. Journal of Thermal Analysis and Calorimetry. 2023;148(14):6761-77. doi:org/10.1007/s10973-023-12198-x

Moyo P, Invernizzi L, Mianda SM, Rudolph W, Andayi WA, Wang M, Crouch NR, Maharaj VJ. Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery. Natural Products and Bioprospecting. 2023;13(1):35. doi:org/10.1007/s13659-023-00396-x

Moyo P, Invernizzi L, Mianda SM, Rudolph W, Andayi AW, Wang M, Crouch NR, Maharaj VJ. Prioritised identification of structural classes of natural products from higher plants in the expedition of antimalarial drug discovery. Natural Products and Bioprospecting. 2023;13(1):37. doi:org/10.1007/s13659-023-00402-2

Patrick SM, Bendiane M-K, Kruger T, Harris BN, Riddin MA, Trehard H, de Jager C, Bornman B, Gaudart J. Household living conditions and individual behaviours associated with malaria risk: a community-based survey in the Limpopo River Valley, 2020, South Africa. Malaria Journal. 2023;22(1):156. doi:org/10.1186/s12936-023-04585-4

Raman J. Vaccines could be a game-changer in the fight against malaria in Africa. South African General Practitioner. 2023;4(1):23-4. doi:org/10.36303/SAGP.0154

Saili K, de Jager C, Sangoro OP, Nkya TE, Masaninga F, Mwenya M, Sinyolo A, Hamainza B, Chanda E, Fillinger U, Mutero CM. Anopheles rufipes implicated in malaria transmission both indoors and outdoors alongside Anopheles funestus and Anopheles arabiensis in rural south-east Zambia. Malar J [Internet]. 2023;22(1):95. doi:org/10.1186/s12936-023-04489-3

Salomé G, Riddin M, Braack L. Species Composition, Seasonal Abundance, and Biting Behavior of Malaria Vectors in Rural Conhane Village, Southern Mozambique. Int. J. Environ. Res. Public Health 2023, 20, 3597. doi:org/10.3390/ijerph20043597 

Stampolaki M, Malwal SR, Alvarez-Cabrera N, Gao Z, Moniruzzaman M, Babii SO, Naziris N, Rey-Cibati A, Valladares-Delgado M, Turcu AL, Baek KH, Phan TN, Lee H, Alcaraz M, Watson S, van der Watt M, Coertzen D, Efstathiou N, Chountoulesi M, Shoen CM, Papanastasiou IP, Brea J, Cynamon MH, Birkholtz LM, Kremer L, No JH, Vázquez S, Benaim G, Demetzos C, Zgurskaya HI, Dick T, Oldfield E, Kolocouris AD. Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites. ACS Infect Dis [Internet]. 2023 Feb 10;9(2):342–64. doi:org/10.1021/acsinfecdis.2c00537

Tchoumi SY, Rwezaura H, Tchuenche JM. A mathematical model with numerical simulations for malaria transmission dynamics with differential susceptibility and partial immunity. Healthcare Analytics [Internet]. 2023;3:100165. doi:org/10.1016/j.health.2023.100165

Tchoumi SY, Njintang NY, Kamgang JC, Tchuenche JM. Malaria and malnutrition in children: A mathematical model. Franklin Open [Internet]. 2023;3:100013. doi:org/10.1016/j.fraope.2023.100013

van Heerden A, Turon G, Duran-Frigola M, Pillay N, Birkholtz L-M. Machine Learning Approaches Identify Chemical Features for Stage-Specific Antimalarial Compounds. ACS Omega. 2023;8(46):43813-43826. doi:org/10.1021/acsomega.3c05664

2022

Abacha YZ, Forkuo AD, Gbedema SY, Mittal N, Ottilie S, Rocamora F, Winzeler EA, van Schalkwyk DA, Kelly JM, Taylor MC, Reader J, Birkholtz L-M, Lisgarten DR, Cockcroft JK, Lisgarten JN, Palmer RA, Talbert RC, Shnyder SD, Wright CW. Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer. Frontiers in Pharmacology. 2022;13:875647. doi:org/10.3389/fphar.2022.875647

An S, Rauch SA, Maphula A, Obida M, Kogut K, Bornman R, Chevrier J, Eskenazi B. In-utero exposure to DDT and pyrethroids and child behavioral and emotional problems at 2 years of age in the VHEMBE cohort, South Africa. Chemosphere. 2022;306:135569. doi:org/10.1016/j.chemosphere.2022.135569

Anderson CM, Eloff I, Kruger T. Could a culturally and age-appropriate song contribute towards malaria prevention in primary school learners? Malaria Journal. 2022;21(1):113. doi:org/10.1186/s12936-022-04120-x

Anderson C, Kruger T, Eloff I. The Influence of a Song on School Children’s Knowledge Growth for Sustainable Malaria Prevention: Teacher Perspectives. Sustainability. 2022;14(22):15023. doi:org/10.3390/su142215023

Arendse LB, Murithi JM, Qahash T, Pasaje CFA, Godoy LC, Dey S, Gibhard L, Ghidelli-Disse S, Drewes G, Bantscheff M, Lafuente-Monasterio MJ, Fienberg S, Wambua L, Gachuhi S, Coertzen D, van der Watt M, Reader J, Aswat AS, Erlank E, Venter N, Mittal N, Luth MR, Ottilie S, Winzeler EA., Koekemoer LL, Birkholtz L, Niles JC, Llinás M, Fidock DA, Chibale K. The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and lifecycle stages. Science Translational Medicine. 2022; 14, eabo7219. doi: 10.1126/scitranslmed.abo7219

Asale A, Kassie M, Abro Z, Enchalew B, Belay A, Sangoro PO, Tchouassi DP, Mutero CM. The combined impact of LLINs, house screening, and pull-push technology for improved malaria control and livelihoods in rural Ethiopia: study protocol for household randomised controlled trial. BMC Public Health [Internet]. 2022;22(1):930. doi:org/10.1186/s12889-022-12919-1

Birkholtz L-M, Alano P, Leroy D. Transmission-blocking drugs for malaria elimination. Trends in Parasitology. 2022; 38(5):390-403. doi:org/10.1016/j.pt.2022.01.011

Bornman R, Acerini CL, Chevrier J, Rauch S, Crause M, Obida M, Eskenazi B. Maternal exposure to DDT, DDE, and pyrethroid insecticides for malaria vector control and hypospadias in the VHEMBE birth cohort study, Limpopo, South Africa. Science of the Total Environment. 2022;845:157084. doi:org/10.1016/j.scitotenv.2022.157084

Coetzee BWT, Gaston KJ, Koekemoer LL, Kruger T, Riddin MA, Smit IPJ. Artificial Light as a Modulator of Mosquito-Borne Disease Risk. Frontiers in Ecology and Evolution. 2022 Jan 25;920. doi:org/10.3389/fevo.2021.768090

Connacher J, von Grüning H, Birkholtz L. Histone Modification Landscapes as a Roadmap for Malaria Parasite Development. Frontiers in Cell and Developmental Biology. 2022;10:1-15. doi:org/10.3389/fcell.2022.848797

DeLay K, Lin EZ, Koelmel JP, Bornman R, Obida M, Chevrier J, Godri Pollitt KJ. Personal air pollutant exposure monitoring in South African children in the VHEMBE birth cohort. Environment International. 2022;107524. doi:org/10.1016/j.envint.2022.107524

Diiro GM, Kassie M, Muriithi BW, Mutero CM. Gender Heterogeneous Effects of Malaria Risk on Agriculture Productivity: Empirical Evidence from Rural Ethiopia. The Journal of Developing Areas. 2022;56(1):73–91. doi:org/10.1353/jda.2022.0011

Kim J, Yang S, Moodie EEM, Obida M, Bornman R, Eskenazi B, Chevrier J. Prenatal exposure to insecticides and child cardiometabolic risk factors in the VHEMBE birth cohort. Environmental Epidemiology. 2022 Apr 1;6(2). doi:10.1097/EE9.0000000000000196

Kinya F, Mutero CM, Sang R, Owino EA, Rotich G, Ogola EO, Wondji CS, Torto B, Tchouassi DP. Outdoor malaria vector species profile in dryland ecosystems of Kenya. Scientific Reports. 2022;12(1):7131. doi:org/10.1038/s41598-022-11333-2

Koelmel JP, Lin EZ, DeLay K, Williams AJ, Zhou Y, Bornman R, Obida M, Chevrier J, Godri Pollitt KJ. Assessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study. Environmental Science & Technology. 2022;28;56(4):2191–2203. doi:org/10.1021/acs.est.1c06481

Mabuza JM, Kaiser M, Bapela MJ. In vitro antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from Pappea capensis EckI & Zeyh. (Sapindaceae). Journal of Ethnopharmacology. 2022;298:115659. doi:org/10.1016/j.jep.2022.115659

Maharaj S, Ekoka E, Erlank E, Nardini L, Reader J, Birkholtz L-M, Koekemoer LL. The ecdysone receptor regulates several key physiological factors in Anopheles funestus. Malaria Journal. 2022 Mar 19;21(1):97. doi:org/10.1186/s12936-022-04123-8

Makhanthisa TI, Braack L, Bornman MS, Lutermann H. Social acceptance of livestock-administered endectocides for malaria control in Vhembe District, Limpopo Province, South Africa. Malaria Journal. 2022;21:307. doi:org/10.1186/s12936-022-04334-z 

Mambwe D, Korkor CM, Mabhula A, Ngqumba Z, Cloete C, Kumar M, Barros PL, Leshabane M, Coertzen D, Taylor D, Gibhard L, Njoroge M, Lawrence N, Reader J, Moreira DR, Birkholtz LM, Wittlin S, Egan TJ, Chibale K. Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model. J Med Chem. 2022;65:16695-16715. doi:org/10.1021/acs.jmedchem.2c01516

Mianda SM, Invernizzi L, van der Watt ME, Reader J, Moyo P, Birkholtz LM, Maharaj VJ. In vitro dual activity of Aloe marlothii roots and its chemical constituents against Plasmodium falciparum asexual and sexual stage parasites. J Ethnopharmacol. 2022;297:115551. doi:org/10.1016/j.jep.2022.115551

Moyo DS, Mapossa AB, Rademeyer M, van der Merwe EM, Focke WW. TGA investigation of the volatilisation of fipronil at elevated temperatures. Thermochimica Acta. 2022:179379. doi:org/10.1016/j.tca.2022.179379

Mphateng TN, Mapossa AB, Wesley-Smith J, Ramjee S, Focke WW. Cellulose acetate/organoclay nanocomposites as controlled release matrices for pest control applications. Cellulose. 2022;29(7):3915-33. doi:org/10.1007/s10570-022-04533-6

Ng JPL, Han Y, Yang, LJ, Birkholtz LM, Coertzen D, Wong HN, Haynes RK, Coghi P, Wong VKW. Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue. Front Pharmacol. 2022;3516. doi:org/10.3389/fphar.2022.988748

Nkya TE, Fillinger U, Sangoro OP, Marubu R, Chanda E, Mutero CM. Six decades of malaria vector control in southern Africa: a review of the entomological evidence-base. Malaria Journal. 2022;21(1):279. doi:org/10.1186/s12936-022-04292-6

Patrick SM, Cox SN, Guidera KE, Simon MJ, Kruger T, Bornman R. COVID-19 and the malaria elimination agenda in Africa: Re-shifting the focus. Global Public Health. 2022:1-12. doi:org/10.1080/17441692.2022.2129729

Ochola JB, Mutero CM, Marubu RM, Haller BF, Hassanali A, Lwande W. Mosquitoes Larvicidal Activity of Ocimum kilimandscharicum Oil Formulation under Laboratory and Field-Simulated Conditions. Insects [Internet]. 2022;13(2). doi:org/10.3390/insects13020203

Olivier T, Loots L, Kok M, de Villiers M, Reader J, Birkholtz LM, Arnott GE, de Villiers KA. Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine β-Hematin Inhibitors. ChemMedChem. 2022;17(10):e202200139. doi:org/10.1002/cmdc.202200139

Reader J, Opperman D, van der Watt M, Theron A, Leshabane M, da Rocha S, Turner J, Garrabrant K, Piña I, Mills C, Woster P, Birkholtz LM. New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1′-Biphenyl]-4-carboxamido)benzoic Acid Derivatives. ChemBioChem. e202200427.doi:org/10.1002/cbic.202200427

Reader J, van der Watt ME, Birkholtz LM. Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds Against Plasmodium falciparum. Front Cell Infect Microbiol. 2022;12:926460. doi:org/10.3389/fcimb.2022.926460

Tchoumi SY, Chukwu CW, Diagne ML, Rwezaura H, Juga ML, Tchuenche JM. Optimal control of a two-group malaria transmission model with vaccination. Network Modeling Analysis in Health Informatics and Bioinformatics [Internet]. 2022;12(1):7. doi:org/10.1007/s13721-022-00403-0

van der Watt ME, Reader J, Birkholtz L-M. Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria Elimination. Frontiers in Cellular and Infection Microbiology. 2022;12:901971. doi:org/10.3389/fcimb.2022.901971

von Grüning H, Coradin M, Mendoza MR, Reader J, Sidoli S, Garcia BA, Birkholtz L-M. A dynamic and combinatorial histone code drives malaria parasite asexual and sexual development. Molecular & Cellular Proteomics. 2022 Jan 17:100199. doi:org/10.1016/j.mcpro.2022.100199

Yener HE, Erdmann R, Jariyavidyanont K, Mapossa AB, Focke WW, Hillrichs G, Androsch R. Slow-DEET-Release Mosquito-Repellent System Based on Poly(butylene succinate). ACS Omega. 2022;7(10):8377-84. doi:org/10.1021/acsomega.1c05897

Bapela MJ, Mabuza MJ, Ramontja PB. Pharmacological appraisal of ethnomedicinal antimalarial plant species, 22pg. In: Lall N. (Ed.). (2022). Medicinal Plants for Cosmetics, Health and Diseases (1st ed.), 576pg. CRC Press.   doi:org/10.1201/9781003108375

2021

Asale A, Abro Z, Enchalew B, Teshager A, Belay A, Kassie M, Mutero CM. Community knowledge, perceptions, and practices regarding malaria and its control in Jabi Tehnan district, Amhara Region, Northwest Ethiopia. Malaria Journal. 2021;20(1):459. doi:org/10.1186/s12936-021-03996-5

Banasiak J, Ouifki R, Woldegerima WA. Some mathematical tools for modelling malaria: a subjective survey. BIOMATH. 2021;10(2):2110029. doi:org/10.11145/j.biomath.2021.10.029

Bath D, Cook J, Govere J, Mathebula P, Morris N, Hlongwana K, Raman J, Seocharan I, Zitha A, Zitha M, Mabuza A, Mbokazi F, Machaba E, Mabunda E, Jamesboy E, Biggs J, Drakeley C, Moonasar D, Maharaj R, Coetzee M, Pitt C, Kleinschmidt I. Effectiveness and cost-effectiveness of reactive, targeted indoor residual spraying for malaria control in low-transmission settings: a cluster-randomised, non-inferiority trial in South Africa. The Lancet. 2021;397(10276):816–27. doi:org/10.1016/s0140-6736(21)00251-8

Cheuka PM, Centani L, Arendse LB, Fienberg S, Wambua L, Renga SS, Dziwornu GA, Kumar M, Lawrence N, Taylor D, Wittlin S, Coertzen D, Reader J, van der Watt M, Birkholtz L, Chibale K. New amidated 3, 6-Diphenylated Imidazopyridazines with potent antiplasmodium activity are dual inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-dependent protein kinase. ACS Infectious Diseases. 2021;7(1):34-36. doi:10.1021/acsinfecdis.0c00481

Coertzen D, Reader J, van der Watt ME, Leshabane MM, Langeveld H, Cheuka PM, Dziwornu GA, Chibale K, Birkholtz L-M. Exploring the transmission-blocking activity of antiplasmodial 3,6-diarylated imidazopyridazines. Transactions of the Royal Society of South Africa. 2021;1–9. doi:org/10.1080/0035919X.2021.1982792

Connacher J, Josling GA, Orchard LM, Reader J, Llinás M, Birkholtz LM. H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum. Epigenetics and Chromatin. 2021;14(1):1-15. doi:org/10.1186/s13072-021-00393-9

Diouf I, Adeola AM, Abiodun GJ, Lennard C, Shirinde JM, Yaka P, Ndione J-A, Gbobaniyi EO. Impact of future climate change on malaria in West Africa. Theoretical and Applied Climatology. 2021. doi:org/10.1007/s00704-021-03807-6

Dziwornu GA, Coertzen D, Leshabane M, Korkor CM, Cloete CK, Njoroge M, Gibhard L, Lawrence N, Reader J, van der Watt M, Wittlin S, Birkholtz LM, Chibale K. Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure–Activity Relationship and In Vivo Oral Efficacy Studies. Journal of Medicinal Chemistry. 2021;64(8):5198-215. doi:org/10.1021/acs.jmedchem.1c00354

Feldman M, Vernaeve L, Tibenderana J, Braack L, Debackere M, Thu HK, Hamade P, Lo K. Navigating the COVID-19 Crisis to Sustain Community-Based Malaria Interventions in Cambodia. Global Health: Science and Practice [Internet]. 2021;9(2):344–54. doi:org/10.9745/GHSP-D-20-00528

Ferreira I, Brünig H, Focke W, Boldt R, Androsch R, Leuteritz A. Melt-Spun Poly (D, L-lactic acid) Monofilaments Containing N, N-Diethyl-3-Methylbenzamide as Mosquito Repellent. Materials. 2021;14(3):638. doi:org/10.3390/ma14030638

Gibhard L, Coertzen D, Reader J, van der Watt ME, Birkholtz L-M, Wong HN, Batty KT, Haynes RK, Wiesner L. The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside. Pharmaceutics. 2021;13(12). doi:org/10.3390/pharmaceutics13122066

Gwarinda HB, Tessema SK, Raman J, Greenhouse B, Birkholtz LM. Parasite genetic diversity reflects continued residual malaria transmission in Vhembe District, a hotspot in the Limpopo Province of South Africa. Malaria Journal. 2021;20(1):1-13. doi:org/10.1186/s12936-021-03635-z

Kapwata T, Wright CY, du Preez DJ, Kunene Z, Mathee A, Ikeda T, Landman W, Maharaj R, Sweijd N, Minakawa N, Blesic S. Exploring rural hospital admissions for diarrhoeal disease, malaria, pneumonia, and asthma in relation to temperature, rainfall and air pollution using wavelet transform analysis. Science of The Total Environment. 2021;791:148307. doi:org/10.1016/j.scitotenv.2021.148307

Le Manach C, Dam J, Woodland JG, Kaur G, Khonde LP, Brunschwig C, Njoroge M, Wicht KJ, Horatscheck A, Paquet T, Boyle GA, Gibhard L, Taylor D, Lawrence N, Yeo T, Mok S, Eastman RT, Dorjsuren D, Talley DC, Guo H, Simeonov A, Reader J, van der Watt M, Erlank E, Venter N, Zawada JW, Aswat A, Nardini L, Coetzer TL, Lauterbach SB, Bezuidenhout BC, Theron A, Mancama D, Koekemoer LL, Birkholtz LM, Wittlin S, Delves M, Ottilie S, Winzeler EA, von Geldern TW, Smith D, Fidock DA, Street LJ, Basarab GS, Duffy J, Chibale K. Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts. Journal of Medicinal Chemistry. 2021;64(4):2291-309. doi:org/10.1021/acs.jmedchem.1c00034

Leshabane M, Dziwornu GA, Coertzen D, Reader J, Moyo P, van der Watt M, Chisanga K, Nsanzubuhoro C, Ferger R, Erlank E, Venter N, Koekemoer LL, Chibale K, Birkholtz LM. Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites. ACS Infectious Diseases. 2021 Jul 9;7(7):1945–55. doi:org/10.1021/acsinfecdis.0c00910

Maharaj L, Adeleke VT, Fatoba AJ, Adeniyi AA, Tshilwane SI, Adeleke MA, Maharaj R, Okpeku M. Immunoinformatics approach for multi-epitope vaccine design against P. falciparum malaria. Infection, Genetics and Evolution. 2021;92:104875. doi:org/10.1016/j.meegid.2021.104875

Makhanthisa TI, Braack L, Lutermann H. The effect of cattle-administered ivermectin and fipronil on the mortality and fecundity of Anopheles arabiensis Patton. Parasites & Vectors. 2021;14(1):349. doi:org/10.1186/s13071-021-04846-8

Mambwe D, Kumar M, Ferger R, Taylor D, Njoroge M, Coertzen D, Reader J, van der Watt M, Birkholtz L-M, Chibale K. Structure–Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro. ACS Medicinal Chemistry Letters. 2021;12(8):1333–41. doi:org/10.1021/acsmedchemlett.1c00328

Mapossa AB, Focke WW, Tewo RK, Androsch R, Kruger T. Mosquito‐repellent controlled‐release formulations for fighting infectious diseases. Malaria Journal. 2021;20(1):1-33. doi:org/10.1186/s12936-021-03681-7

Mapossa AB, López-Beceiro J, Díaz-Díaz AM, Artiaga R, Moyo DS, Mphateng TN, Focke WW. Properties of Mosquito Repellent-Plasticized Poly(lactic acid) Strands. Molecules. 2021;26(19). doi:org/10.3390/molecules26195890

Mapossa AB, Sibanda MM, Moyo D, Kruger T, Focke WW, Androsch R, Boldt R, Wesley-Smith J. Blooming of insecticides from polyethylene mesh and film. Transactions of the Royal Society of South Africa. 2021; 0(0):1-10. doi:10.1080/0035919X.2021.1900950

Moonasar DM, Davies C, Balawanth R, Misiani E, Shandukani MB, Raman J, Pillay YG. Progress, challenges and priorities for malaria elimination in South Africa. Transactions of the Royal Society of South Africa [Internet]. 2021;76(2):105–16. doi:org/10.1080/0035919X.2021.1890274

Nabet C, Kone AK, Dia AK, Sylla M, Gautier M, Yattara M, Thera MA, Faye O, Braack L, Manguin S, Beavogui AH, Doumbo O, Gay F, Piarroux R. New assessment of Anopheles vector species identification using MALDI-TOF MS. Malaria Journal. 2021;20(1):33. doi:org/10.1186/s12936-020-03557-2

Ndwiga L, Kimenyi KM, Wamae K, Osoti V, Akinyi M, Omedo I, Ishengoma DS, Duah-Quashie N, Andagalu B, Ghansha A, Amambua-Ngwa A, Tukwasibwe S, Tessema SK, Karema C, Djimde AA, Dondorp AM, Raman J, Snow RW, Bejon P, Ochola-Oyier LI. A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa. International Journal for Parasitology: Drugs and Drug Resistance. 2021;16:155–61. doi:org/10.1016/j.ijpddr.2021.06.001

Ng’ang’a PN, Aduogo P, Mutero CM. Long lasting insecticidal mosquito nets (LLINs) ownership, use and coverage following mass distribution campaign in Lake Victoria basin, Western Kenya. BMC Public Health. 2021;21(1):1046. doi:org/10.1186/s12889-021-11062-7

Ng'ang'a PN, Aduogo P, Mutero CM. Strengthening community and stakeholder participation in the implementation of integrated vector management for malaria control in western Kenya: a case study. Malaria Journal. 2021; 20(155). doi:10.1186/s12936-021-03692-4

Ng'etich AKS, Voyi K, Kirinyet RC, Mutero CM. A systematic review on improving implementation of the revitalised integrated disease surveillance and response system in the African region: A health workers' perspective. PLoS One. 2021; 16(3):e0248998. doi:10.1371/journal.pone.0248998

Niemand J, van Biljon R, van der Watt M, van Heerden A, Reader J, van Wyk R, Orchard L, Chibale K, Llinás M, Birkholtz L-M. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infectious Diseases. 2021;7(10):2904–16. doi:org/10.1021/acsinfecdis.1c00373

Njau J, Silal SP, Kollipara A, Fox K, Balawanth R, Yuen A, White LJ, Moya M, Pillay Y, Moonasar D. Investment case for malaria elimination in South Africa: a financing model for  resource mobilization to accelerate regional malaria elimination. Malaria journal. 2021 Aug;20(1):344. doi:org/10.1186/s12936-021-03875-z

Nkya TE, Fillinger U, Dlamini M, Sangoro OP, Marubu R, Zulu Z, Mutero CM. Malaria in Eswatini, 2012–2019: a case study of the elimination effort. Malaria Journal. 2021; 20(159). doi:10.1186/s12936-021-03699-x

Raman J, Fakudze P, Sikaala CH, Chimumbwa J, Moonasar D. Eliminating malaria from the margins of transmission in Southern Africa through the Elimination 8 Initiative. Transactions of the Royal Society of South Africa [Internet]. 2021;76(2):137–45. doi:org/10.1080/0035919X.2021.1915410

Raman J, K I Barnes KI, Baker L, Blaylock M, Blumberg L, Frean J, Misiani E, Ukpe IS. Maintaining focus on administering effective malaria treatment during the COVID-19 pandemic. South African Medical Journal. 2021;111(1):13-16. doi:10.7196/SAMJ.2020.v111i11.15289

Reader J, van der Watt ME, Taylor D, Le Manach C, Mittal N, Ottilie S, Theron A, Moyo P, Erlank E, Nardini L, Venter N, Lauterbach S, Bezuidenhout B, Horatscheck A, van Heerden A, Boyle GA, Calvo D, Mancama D, Coetzer TL, Winzeler EA, Duffy J, Koekemoer LL, Basarab G, Chibale K, Birkholtz L-M. Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box. Nature Communations. 2021;12(269). doi:org/10.1038/s41467-020-20629-8

Roux AT, Maharaj L, Oyegoke O, Akoniyon OP, Adeleke MA, Maharaj R, Okpeku M. Chloroquine and Sulfadoxine-Pyrimethamine Resistance in Sub-Saharan Africa-A Review. Frontiers in genetics [Internet]. 2021 Jun 25;12:668574. doi:org/10.3389/fgene.2021.668574

Sangoro OP, Fillinger U, Saili K, Nkya TE, Marubu R, Masaninga F, Trigo SC, Tarumbwa C, Hamainza B, Baltazar C, Mberikunashe J, Chisanga B, Menale K, Chanda E, Mutero CM. Evaluating the efficacy, impact, and feasibility of community-based house screening as a complementary malaria control intervention in southern Africa: a study protocol for a household randomized trial. Trials. 2021;22(1):883. doi:org/10.1186/s13063-021-05768-7

Sitoe AJ, Pretorius F, Focke WW, Androsch R, du Toit EL. Solid–liquid–liquid phase envelopes from temperature-scanned refractive index data. Journal of Polymer Engineering. 2021;41(7):517–27. doi:org/10.1515/polyeng-2021-0062

Sitoe A, Mapossa AB, Focke WW, Muiambo H, Androsch R, Wesley-Smith J. Development, characterization and modeling of mosquito repellent release from microporous devices. SPE Polymers. 2020;1(2):90-100. doi:org/10.1002/pls2.10021

Teboh-Ewungkem MI, Woldegerima WA, Ngwa GA. Mathematical assessment of the impact of human-antibodies on sporogony during the within-mosquito dynamics of Plasmodium falciparum parasites. Journal of Theoretical Biology. 2021;515:110562. doi:org/10.1016/j.jtbi.2020.110562

Van Heerden A, van Wyk R, Birkholtz LM. Machine Learning Uses Chemo-Transcriptomic Profiles to Stratify Antimalarial Compounds With Similar Mode of Action. Frontiers in Cellular and Infection Microbiology. 2021;11:558. doi:org/10.3389/fcimb.2021.688256

van Wyk R, van Biljon R, Birkholtz L-M. MALBoost: a web-based application for gene regulatory network analysis in Plasmodium falciparum. Malaria Journal. 2021;20(1):317. doi:org/10.1186/s12936-021-03848-2

Woldegerima WA, Ouifki R, Banasiak J. Mathematical analysis of the impact of transmission-blocking drugs on the population dynamics of malaria. Applied Mathematics and Computation. 2021;400:126005. doi:org/10.1016/j.amc.2021.126005

Wooding M, Dodgen T, Rohwer ER, Naudé Y. Mass spectral studies on the human skin surface for mosquito vector control applications. Journal of Mass Spectrometry [Internet]. 2021;56(2):e4686. doi:org/10.1002/jms.4686

Forbes P, Naudé Y, Strumpher J. (2021). Ongoing Use and Monitoring of DDT in South Africa, 33pg. In: Kumar N, Shukla V. (Eds.). (2021). Persistent Organic Pollutants in the Environment: Origin and Role (1st ed.), 378pg. CRC Press. doi:org/10.1201/9781003053170

2020

Abiodun GJ, Adebiyi B, Abiodun RO, Oladimeji O, Oladimeji KE, Adeola AM, Makinde OS, Okosun KO, Djidjou-Demasse R, Semegni YJ. Njabo KY, Witbooi PJ, Aceves A. Investigating the resurgence of malaria prevalence in South Africa between 2015 and 2018: A scoping review. The Open Public Health Journal. 2020;13(1):119-125. doi:10.2174/1874944502013010119

Ahenkorah S, Coertzen D, Tong JX, Fridianto K, Wittlin S, Birkholtz LM, Tan KS, Lam Y, Go ML, Haynes RK. Antimalarial N 1, N 3-Dialkyldioxonaphthoimidazoliums: Synthesis, biological activity, and structure–activity relationships. ACS Medicinal Chemistry Letters. 2019;11(1):49-55.  doi:10.1021/acsmedchemlett.9b00457

Braack L, Bornman MS, Kruger T, Dahan-Moss Y, Gilbert A, Kaiser M, Oliver SV, Cornel AJ, Lee Y, Norris DE, Coetzee M, Brooke B, de Jager C. Malaria vectors and vector surveillance in Limpopo Province (South Africa): 1927 to 2018. International Journal of Environmental Research and Public Health. 2020,17:425. doi:10.3390/ijerph17114125

Brooke BD, Raman J, Frean J, Rundle K, Maartens F, Misiani E, Mabuza A, Barnes KI, Moonasar DP, Dlamini Q, Charles S, Blumberg L. Implementing malaria control in South Africa, Eswatini and southern Mozambique during the COVID-19 pandemic. South African Medical Journal. 2020;110(11):1072-1076. doi:10.7196/SAMJ.2020.v110i11.15286

Coetzee N, von Grüning H, Opperman D, van der Watt M, Reader J, Birkholtz LM. Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites. Scientific Reports. 2020;10(1):1-1. doi:org/10.1038/s41598-020-59298-4

Coetzer RH, Adeola AM. Assessing the correlation between malaria case mortality rates and access to health facilities in the malaria region of Vhembe district, South Africa. Journal of Environmental and Public Health. 2020;2020:1-15. doi:org/10.1155/2020/8973739

Cupul-Uicab LA, Bornman R, Archer JI, Kudumu MO, Travlos GS, Wilson RE, Whitworth KW. Exposure to DDT from indoor residual spraying and biomarkers of inflammation among reproductive-aged women from South Africa. Environmental Research. 2020;1:191:110088. doi:10.1016/j.envres.2020.110088

Di Lenardo TZ, Ward BJ, Pillet S, Mann K, Bornman R, Obida M, Chevrier J. Exposure to lead and vaccine-specific IgG titers in South African children participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE): A longitudinal study.  Environmental Research, 2020;180:108794. doi:org/10.1016/j.envres.2019.108794

Diiro GM, Kassie M, Muriithi BW, Gathogo NG, Kidoido M, Marubu R, Bwire Ochola J, Mutero CM. Are individuals willing to pay for community-based eco-friendly malaria vector control strategies? A case of mosquito larviciding using plant-based biopesticides in Kenya. Sustainability. 2020;12(20):8552. doi:org/10.3390/su12208552

Djidjou‐Demasse R, Abiodun GJ, Adeola AM, Botai JO. Development and analysis of a malaria transmission mathematical model with seasonal mosquito life‐history traits. Studies in Applied Mathematics. 2020;144(4):389-411. doi:org/10.1111/sapm.12296

Duvenhage J, Ebenhan T, Garny S, González IH, Montaña RL, Price R, Birkholtz L-M, Zeevaart JR. Molecular imaging of a zirconium-89 labeled antibody targeting Plasmodium falciparum–infected human erythrocytes. Molecular Imaging and Biology. 2020;22(1):115-23. doi:10.1007/s11307-019-01360-3

Fortuin L, Leshabane M, Pfukwa R, Coertzen D, Birkholtz LM, Klumperman B. Facile route to targeted, biodegradable polymeric prodrugs for the delivery of combination therapy for malaria. ACS Biomaterials Science & Engineering. 2020; 6(11):6217-6227. doi:org/10.1021/acsbiomaterials.0c01234

Horatscheck A, Andrijevic A, Nchinda A, Le Manach C, Paquet T, Khonde L, Dam J, Pawar K, Taylor D, Lawrence N, Brunschwig C, Gibhard L, Njoroge M, Reader J, van der Watt M, Wicht K, de Sousa A,  Okombo J, Maepa K,  Egan T, Birkholtz L, Basarab G, Wittlin S, Fish P, Street L, Duffy J, Chibale K. Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast killing kinetics and in vivo efficacy in the Plasmodium falciparum NSG mouse model. Journal of Medicinal Chemistry. 2020;63(21): 13013-13030. doi:10.1021/acs.jmedchem.0c01411

Huq F, Obida M, Bornman R, Di Lenardo T, Chevrier J. Associations between prenatal exposure to DDT and DDE and allergy symptoms and diagnoses in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE), South Africa. Environmental Research. 2020:109366. doi:10.1016/j.envres.2020.109366

Johnson T, Braack L, Guarido M, Venter M, Gouveia Almeida AP. Mosquito community composition and abundance at contrasting sites in northern South Africa, 2014-2017. Journal of Vector Ecology. 2020;45(1). doi:org/10.1111/jvec.12378

Jokonya S, Langlais M, Leshabane M, Reader PW, Vosloo JA, Pfukwa R, Coertzen D, Birkholtz LM, Rautenbach M, Klumperman B. Poly (N-vinylpyrrolidone) antimalaria conjugates of membrane-disruptive peptides. Biomacromolecules. 2020. doi:org/10.1021/acs.biomac.0c01202

Kgoroebutswe TK, Makate N, Fillinger U, Mpho M, Segoea G, Sangoro PO, Mutero CM, Chanda E, Ntebela D, Mogopa M, Mosweunyane T, Nkya TE. Vector control for malaria elimination in Botswana: progress, gaps and opportunities. Malaria Journal. 2020;19(1):301. doi:org/10.1186/s12936-020-03375-6

Makondo L, Adeola A, Makgoale T, Botai J, Adisa O, Botai C. Influence of Climate on the Spatiotemporal Distribution of Malaria in Thulamela Municipality, Limpopo Province, South Africa. The Open Public Health Journal. 2020;13(1):246-56. doi:org/10.2174/1874944502013010246

Mapossa AB, Sitoe A, Focke WW, Izadi H, du Toit EL, Androsch R, Sungkapreecha C, van der Merwe EM. Mosquito repellent thermal stability, permeability and air volatility. Pest Management Science. 2020,76(3):1112-1120. doi:org/10.1002/ps.5623

Morahan BJ, Abrie C, Al-Hasani K, Batty MB, Corey V, Cowell AN, Niemand J, Winzeler EA, Birkholtz LM, Doerig C, Garcia-Bustos JF. Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases. Communications Biology. 2020;3(1):1-10. doi:10.1038/s42003-020-01424-z 

Moyo P, Shamburger W, van der Watt ME, Reader J, de Sousa ACC, Egan TJ, Maharaj VJ, Bringmann G, Birkholtz L-M. Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products. International Journal for Parasitology: Drugs and Drug Resistance. 2020;13:51-58. doi:org/10.1016/j.ijpddr.2020.05.003

Moyo P, Mugumbate G, Eloff JN, Louw AI, Maharaj VJ, Birkholtz LM. Natural Products: A potential source of malaria transmission blocking drugs? Pharmaceuticals. 2020;13(9):251. doi:org/10.3390/ph13090251

Mutero CM, Okoyo C, Girma M, Mwangangi J, Kibe L, Ng’ang’a P, et al. Evaluating the impact of larviciding with Bti and community education and mobilization as supplementary integrated vector management interventions for malaria control in Kenya and Ethiopia. Malaria Journal. 2020;19:390. doi:10.1186/s12936-020-03464-6

Ng’ang’a PN, Okoyo C, Mbogo C, Mutero CM. Evaluating effectiveness of screening house eaves as a potential intervention for reducing indoor vector densities and malaria prevalence in Nyabondo, western Kenya. Malaria Journal. 2020;19(1):341. doi.org/10.1186/s12936-020-03413-3

Ngwa GA, Woldegerima WA, Teboh-Ewungkem MI. A mathematical study of the implicit role of innate and adaptive immune responses on within-human Plasmodium falciparum parasite levels. Journal of Biological Systems. 2020;28(02):377-429. doi:org/10.1142/S0218339020400069

Raman J, Gast L, Balawanth R, Tessema S, Brooke B, Maharaj R, Munhenga G, Tshikae P, Lakan V, Mwamba T, Makowa H, Sangweni L, Mkhabela M, Zondo N, Mohulatsi E, Nyawo Z, Ngxongo S, Msimang S, Dagata N, Greenhouse B, Birkholtz LM, Shirref G, Graffy R, Qwabe B, Moonasar D. High levels of imported asymptomatic malaria but limited local transmission in KwaZulu-Natal, a South African malaria-endemic province nearing malaria elimination. Malaria journal. 2020;19:1-13. doi:org/10.1186/s12936-020-03227-3

Sitoe A, Mapossa AB, Focke WW, Muiambo H, Androsch R, Wesley-Smith J. Development, characterization and modeling of mosquito repellent release from microporous devices. SPE Polymers. 2020;1(2):90–100. doi:org/10.1002/pls2.10021

Sungkapreecha C, Focke WW, Androsch R. Competition between Liquid-liquid de-mixing, crystallization, and glass transition in solutions of PLA of different stereochemistry and DEET. Chinese Journal of Polymer Science (English Edition). 2020;38(2):174-8. doi:org/10.1007/s10118-019-2314-0C

Wong HN, Padín-Irizarry V, van der Watt ME, Reader J, Liebenberg W, Wiesner L, Smith P, Eribez K, Winzeler EA, Kyle DE, Birkholtz LM. Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies–activities against blood stage P. falciparum including PfKI3 C580Y mutants and liver stage P. berghei parasites. Frontiers in Chemistry. 2020;7:901. doi:org/10.3389/fchem.2019.00901

Wooding M, Rohwer ER, Naudé Y, Bouwer M. Controlling mosquitoes with semiochemicals: a review. Parasites Vectors. 2020;13:80. doi:org/10.1186/s13071-020-3960-3

​Wooding M, Rohwer ER, Naudé Y. Non-invasive sorptive extraction for the separation of human skin surface chemicals using comprehensive gas chromatography coupled to time-of-flight mass spectrometry: a mosquito-host biting site investigation. Journal of Separation Science. 2020;1-14. doi:10.1002/jssc.202000522

Wooding M, Rohwer ER, Naudé Y. Chemical profiling of the human skin surface for malaria vector control via a non-invasive sorptive sampler with GC× GC-TOFMS. Analytical and Bioanalytical Chemistry. 2020:1-19. doi:org/10.1007/s00216-020-02799-y

2019

Abiodun GJ, Makinde OS, Adeola AM, Njabo KY, Witbooi PJ, Djidjou-Demasse R, Botai JO. A dynamical and zero-inflated negative binomial regression modelling of malaria incidence in Limpopo Province, South Africa. International Journal of Environmental Research and Public Health. 2019;16(11):2000. doi:10.3390/ijerph16112000

Adeola AM, Botai JO, Olwoch JM, Rautenbach HCdW, Adisa OM, de Jager C, Botai CM, Aaron M. Predicting malaria cases using remotely sensed environmental variables in Nkomazi, South Africa. Geospatial health. 2019;14(1). doi:10.4081/gh.2019.676

Adeola A, Ncongwane K, Abiodun G, Makgoale T, Rautenbach H, Botai J, Adisa O, Botai C. Rainfall trends and malaria occurrences in Limpopo province, South Africa. International Journal of Environmental Research and Public Health. 2019;16(24):5156. doi:org/10.3390/ijerph16245156

Awandu SS, Raman J, Bousema T, Birkholtz L-M. Ultralow-density Plasmodium falciparum infections in African settings. Clinical Infectious Diseases. 2019;69(8):1463-4. doi:10.1093/cid/ciz147

Bapela MJ, Heyman H, Senejoux F, Meyer JM. 1H NMR-based metabolomics of antimalarial plant species traditionally used by Vha-Venda people in Limpopo Province, South Africa and isolation of antiplasmodial compounds. Journal of ethnopharmacology. 2019;228:148-55. doi:org/10.1016/j.jep.2018.07.022

Chevrier J, Rauch S, Obida M, Crause M, Bornman R, Eskenazi B. Sex and poverty modify associations between maternal peripartum concentrations of DDT/E and pyrethroid metabolites and thyroid hormone levels in neonates participating in the VHEMBE study, South Africa. Environment international. 2019;131:104958. doi:10.1016/j.envint.2019.104958

Chevrier J, Rauch S, Crause M, Obida M, Gaspar F, Bornman R, Eskenazi B. Associations of maternal exposure to dichlorodiphenyltrichloroethane and pyrethroids with birth outcomes among participants in the Venda health examination of mothers, babies and their environment residing in an area sprayed for malaria control. American journal of epidemiology. 2019;188(1):130-40. doi:10.1093/aje/kwy143

Danquah B, Chirove F, Banasiak J. Effective and ineffective treatment in a malaria model for humans in an endemic region. Afrika Matematika. 2019;30(7-8):1181-204. doi:org/10.1007/s13370-019-00713-z

Eskenazi B, Levine DI, Rauch S, Obida M, Crause M, Bornman R, Chevrier J. A community-based education programme to reduce insecticide exposure from indoor residual spraying in Limpopo, South Africa. Malaria journal. 2019;18(1):199. doi:org/10.1186/s12936-019-2828-5

Fahey CA, Chevrier J, Crause M, Obida M, Bornman R, Eskenazi B. Seasonality of antenatal care attendance, maternal dietary intake, and fetal growth in the VHEMBE birth cohort, South Africa. PloS one. 2019;14(9):e0222888. doi:10.1371/journal.pone.0222888

Madzorera T, Sibanda M, Focke W, Madito M, Manyala N. Malathion-filled trilayer polyolefin film for malaria vector control. Materials Science and Engineering: C. 2019;96:419-25. doi:org/10.1016/j.msec.2018.11.057

Mapossa AB, Sibanda MM, Sitoe A, Focke WW, Braack L, Ndonyane C, Mouatcho J, Smart J, Muaimbo H, Androsch R. Microporous polyolefin strands as controlled-release devices for mosquito repellents. Chemical Engineering Journal. 2019;360:435-44. doi:org/10.1016/j.cej.2018.11.237

Moyo P, Kunyane P, Selepe MA, Eloff JN, Niemand J, Louw AI, Maharaj VJ, Birkholtz L-M. Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae). Malaria journal. 2019;18(1):1-11. doi:org/10.1186/s12936-019-2694-1

Mukhtar AY, Munyakazi JB, Ouifki R. Assessing the role of climate factors on malaria transmission dynamics in South Sudan. Mathematical biosciences. 2019;310:13-23. doi:10.1016/j.mbs.2019.01.002

Mwendera CA, de Jager C, Longwe H, Kumwenda S, Hongoro C, Phiri K, Mutero CM. Challenges to the implementation of malaria policies in Malawi. BMC health services research. 2019;19(1):1-9. doi:org/10.1186/s12913-019-4032-2

Ngwa GA, Teboh-Ewungkem MI, Dumont Y, Ouifki R, Banasiak J. On a three-stage structured model for the dynamics of malaria transmission with human treatment, adult vector demographics and one aquatic stage. Journal of theoretical biology. 2019;481:202-22. doi:org/10.1016/j.jtbi.2018.12.043

Sibanda M, Leuteritz A, Brünig H, Focke W, editors. Development of polyolefin bicomponent filaments as controlled release devices of volatile repellents for use in malaria vector control. AIP Conference Proceedings; 2019: AIP Publishing LLC. doi:org/10.1063/1.5084839

Sungkapreecha C, Iqbal N, Focke WW, Androsch R. Crystallization of poly (l‐lactic acid) in solution with the mosquito‐repellent N, N‐diethyl‐3‐methylbenzamide. Polymer Crystallization. 2019;2(1):e10029. doi:org/10.1002/pcr2.10029

Van Biljon R, Van Wyk R, Painter HJ, Orchard L, Reader J, Niemand J, Llinás M, Birkholtz L-M. Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation. BMC genomics. 2019;20(1):1-16. doi:org/10.1186/s12864-019-6322-9

de Jager C, Kruger T, Tosh C. Research, Innovation and Education Towards Malaria Elimination: Improving Quality of Life in Africa.  In: Eloff I. (Eds) Handbook of Quality of Life in African Societies. International Handbooks of Quality-of-Life. 2019, Springer, Cham. doi:org/10.1007/978-3-030-15367-0_9

Jariyavidyanont K, Focke W, Androsch R. Thermal properties of biobased polyamide 11. In: Di Lorenzo ML, Androsch R (Eds) Thermal Properties of Bio-based Polymers. 2019, Spinger, Cham. doi:10.1007/978-3-030-39962-7

2018

Abiodun GJ, Njabo KY, Witbooi PJ, Adeola AM, Fuller TL, Okosun KO, Makinde OS, Botai JO. Exploring the influence of daily climate variables on malaria transmission and abundance of Anopheles arabiensis over Nkomazi local municipality, mpumalanga province, South Africa. Journal of Environmental and Public Health. 2018; 2018: 3143950. doi:10.1155/2018/3143950

Anderson CM, McCrindle CM, Kruger T, McNeill F. Using participatory risk analysis to develop a song about malaria for young children in Limpopo Province, South Africa. Malaria Journal. 2018;17(1):181. doi:org/10.1186/s12936-018-2320-7

Awandu SS, Raman J, Makhanthisa TI, Kruger P, Frean J, Bousema T, Niemand J, Birkholtz L-M. Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa. Malaria journal. 2018;17(1):120. doi:10.1186/s12936-018-2271-z

Beteck RM, Seldon R, Coertzen D, Van Der Watt ME, Reader J, Mackenzie JS, Lamprecht DA, Abraham M, Eribez K, Müller J, Rui F, Zhu G, de Grano RV, Williams ID, Smit FJ, Steyn AJC, Winzeler EA, Hemphill A, Birkholtz L-M, Warner DF, N’Da DD, Haynes RK. Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites. Communications Chemistry. 2018;1(1):1-11. doi:org/10.1038/s42004-018-0062-7

Bornman M, Delport R, Farías P, Aneck-Hahn N, Patrick S, Millar RP, de Jager C. Alterations in male reproductive hormones in relation to environmental DDT exposure. Environment international. 2018;113:281-9. doi:10.1016/j.envint.2017.12.039

Braack L, de Almeida APG, Cornel AJ, Swanepoel R, de Jager C. Mosquito-borne arboviruses of African origin: review of key viruses and vectors. Parasites & vectors. 2018;11(1):29. doi:10.1186/s13071-017-2559-9

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, De Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz L-M, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibaleb K. UCT943, a next-generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria. Antimicrobial agents and chemotherapy. 2018;62(9):e00012-18. doi:10.1128/AAC.00012-18

Coertzen D, Reader J, Van Der Watt M, Nondaba SH, Gibhard L, Wiesner L, Smith P, D'Alessandro S, Taramelli D, Wong HN, Du Preez JL, Wu RWK, Birkholtz L-M, Haynes RK. Artemisone and artemiside are potent panreactive antimalarial agents that also synergize redox imbalance in Plasmodium falciparum transmissible gametocyte stages. Antimicrobial agents and chemotherapy. 2018;62(8):e02214-17. doi:10.1128/AAC.02214-17

Coker E, Chevrier J, Rauch S, Bradman A, Obida M, Crause M, Bornman R, Eskenazi B. Association between prenatal exposure to multiple insecticides and child body weight and body composition in the VHEMBE South African birth cohort. Environment international. 2018;113:122-32. doi:10.1016/j.envint.2018.01.016

Cornel AJ, Lee Y, Almeida APG, Johnson T, Mouatcho J, Venter M, de Jager C, Braack L. Mosquito community composition in South Africa and some neighboring countries. Parasites & vectors. 2018;11(1):1-12. doi:10.1186/s13071-018-2824-6

Cox SN, Guidera KE, Simon MJ, Nonyane BAS, Brieger W, Bornman MS, Kruger PS. Interactive malaria education intervention and its effect on community participant knowledge: the malaria awareness program in Vhembe district, Limpopo, South Africa. International Quarterly of Community Health Education. 2018;38(2):147-58. doi:10.1177/0272684X17749573

De Lange C, Coertzen D, Smit FJ, Wentzel JF, Wong HN, Birkholtz L-M, Haynes RK, N’Da DD. Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives. Bioorganic & Medicinal Chemistry Letters. 2018;28(3):289-92. doi:10.1016/j.bmcl.2017.12.057

Eskenazi B, An S, Rauch SA, Coker ES, Maphula A, Obida M, Crause M, Kogut KR, Bornman R, Chevrier J. Prenatal exposure to DDT and pyrethroids for malaria control and child neurodevelopment: The VHEMBE cohort, South Africa. Environmental health perspectives. 2018;126(04):047004. doi:10.1289/EHP2129

Ferreira I, Focke WW, Du Toit EL. Spontaneous microencapsulation of geraniol by zein. eXPRESS Polymer Letters. 2018;12(11):986-995. doi:10.3144/expresspolymlett.2018.85

Huang J, Eskenazi B, Bornman R, Rauch S, Chevrier J. Maternal peripartum serum DDT/E and urinary pyrethroid metabolite concentrations and child infections at 2 years in the VHEMBE birth cohort. Environmental health perspectives. 2018;126(6):067006. doi:10.1289/EHP2657

Kumar M, Okombo J, Mambwe D, Taylor D, Lawrence N, Reader J, van der Watt M, Fontinha D, Sanches-Vaz M, Bezuidenhout BC, Lauterbach SB, Liebenberg D, Birkholtz L-M, Coetzer TL, Prudêncio M, Egan TJ, Wittlin S, Chibale K. Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action. ACS infectious diseases. 2018;5(2):303-15. doi:10.1021/acsinfecdis.8b00272

Morake M, Coertzen D, Ngwane A, Wentzel JF, Wong HN, Smit FJ, Birkholtz L-M, Pietersen R-D, Baker B, Wiid I. N’Da DD, Haynes RK. Preliminary evaluation of artemisinin–cholesterol conjugates as potential drugs for the treatment of intractable forms of malaria and tuberculosis. 2018;13(1):67-77. doi.org/10.1002/cmdc.201700579

Mouatcho J, Cornel AJ, Dahan-Moss Y, Koekemoer LL, Coetzee M, Braack L. Detection of Anopheles rivulorum-like, a member of the Anopheles funestus group, in South Africa. Malaria Journal. 2018;17(1):1-7. doi:org/10.1186/s12936-018-2353-y

Mukhtar AY, Munyakazi JB, Ouifki R, Clark AE. Modelling the effect of bednet coverage on malaria transmission in South Sudan. PloS one. 2018;13(6):e0198280. doi:10.1371/journal.pone.0198280

Murray J, Eskenazi B, Bornman R, Gaspar FW, Crause M, Obida M, Chevrier J. Exposure to DDT and hypertensive disorders of pregnancy among South African women from an indoor residual spraying region: The VHEMBE study. Environmental research. 2018;162:49-54. doi:10.1016/j.envres.2017.12.006

Nsubuga FW, Rautenbach H. Climate change and variability: a review of what is known and ought to be known for Uganda. International Journal of Climate Change Strategies and Management. 2018;10(5):752-771. doi:10.1108/IJCCSM-04-2017-0090

Roodt AP, Naudé Y, Stoltz A, Rohwer E. Human skin volatiles: passive sampling and GC× GC-ToFMS analysis as a tool to investigate the skin microbiome and interactions with anthropophilic mosquito disease vectors. Journal of Chromatography B. 2018;1097:83-93. doi:org/10.1016/j.jchromb.2018.09.002

Sibanda M, Focke W, Braack L, Leuteritz A, Brünig H, Tran NHA, Wieczorek F, Trümper W. Bicomponent fibres for controlled release of volatile mosquito repellents. Materials Science and Engineering: C. 2018;91:754-61. doi:10.1016/j.msec.2018.06.016

Van Biljon R, Niemand J, van Wyk R, Clark K, Verlinden B, Abrie C, von Grüning H, Smidt W, Smit A, Reader J, Painter H, Llinás M, Doerig C, Birkholtz L-M. Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites. Scientific reports. 2018;8(1):1-14. doi:org/10.1038/s41598-018-34964-w

Van der Watt ME, Reader J, Churchyard A, Nondaba SH, Lauterbach SB, Niemand J, Abayomi S, van Biljon RA, Connacher JI, van Wyk RD, Le Manach C, Paquet T, Cabrera DG, Brunschwig C, Theron A, Lozano-Arias S, Rodrigues JFI, Herreros E, Leroy D, Duffy J, Street LJ, Chibale K, Mancama D, Coetzer TL, Birkholtz L-M. Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials. Journal of Antimicrobial Chemotherapy. 2018;73(5):1279-90. doi: 10.1093/jac/dky008

Verner M-A, Chevrier J, Ngueta G, Rauch S, Bornman R, Eskenazi B. Early-life exposure to p, p′-DDT and p, p′-DDE in South African children participating in the VHEMBE study: An assessment using repeated serum measurements and pharmacokinetic modeling. Environment international. 2018;119:478-84. doi:10.1016/j.envint.2018.07.010

2017

Adeola AM, Botai JO, Rautenbach H, Adisa OM, Ncongwane KP, Botai CM, Adebayo-Ojo TC. Climatic variables and malaria morbidity in Mutale local municipality, South Africa: a 19-year data analysis. International journal of environmental research and public health. 2017;14(11):1360. doi:10.3390/ijerph14111360

Bornman MS, Aneck-Hahn NH, de Jager C, Wagenaar GM, Bouwman H, Barnhoorn IE, Patrick SM, Vandenberg LN, Kortenkamp A, Blumberg B. Endocrine disruptors and health effects in Africa: a call for action. Environmental health perspectives. 2017;125(8):085005. doi:10.1289/EHP1774

Coetzee N, Sidoli S, Van Biljon R, Painter H, Llinás M, Garcia BA, Birkholtz L-M. Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites. Scientific reports. 2017;7(1):1-12. doi:10.1038/s41598-017-00687-7

Gaspar FW, Chevrier J, Quirós-Alcalá L, Lipsitt JM, Barr DB, Holland N, Bornman R, Eskenazi B. Levels and Determinants of DDT and DDE Exposure in the VHEMBE Cohort. Environmental health perspectives. 2017;125(7):077006. doi:10.1289/EHP353

Hajison PL, Mwakikunga BW, Mathanga DP, Feresu SA. Seasonal variation of malaria cases in children aged less than 5 years old following weather change in Zomba district, Malawi. Malaria journal. 2017;16(1):1-12. doi:10.1186/s12936-017-1913-x

Harmse R, Coertzen D, Wong HN, Smit FJ, Van der Watt ME, Reader J, Nondaba S, Birkholtz L-M, Haynes RK, N'Da D. Activities of 11‐azaartemisinin and N‐sulfonyl derivatives against asexual and transmissible malaria parasites. 2017;12(24):2086-2093. doi:10.1002/cmdc.201700599

Izadi H, Focke WW, Asaadi E, Maharaj R, Pretorius J, Loots MT. A promising azeotrope-like mosquito repellent blend. Scientific reports. 2017;7(1):1-11. doi:10.1038/s41598-017-10548-y

Mwendera CA, de Jager C, Longwe H, Hongoro C, Mutero CM, Phiri KS. Malaria research in Malawi from 1984 to 2016: a literature review and bibliometric analysis. Malaria Journal. 2017;16(1):246. doi:org/10.1186/s12936-017-1895-8

Mwendera C, de Jager C, Longwe H, Hongoro C, Phiri K, Mutero CM. Development of a framework to improve the utilisation of malaria research for policy development in Malawi. Health Research Policy and Systems. 2017;15(1):97. doi:10.1186/s12961-017-0264-y

Mwendera CA, de Jager C, Longwe H, Phiri K, Hongoro C, Mutero CM. Changing the policy for intermittent preventive treatment with sulfadoxine–pyrimethamine during pregnancy in Malawi. Malaria journal. 2017;16(1):84. doi:10.1186/s12936-017-1736-9

Paquet T, Le Manach C, Cabrera D, Younis Y, Henrich P, Abraham T, Lee M, Basak R, Ghidelli-Disse S, Lafuente-Monasterio M, Bantscheff M, Ruecker A, Blagborough AM, Zakutansky SE, Zeeman A-M, White KL, Shackleford DM, Paquet J, Morizzi J, Scheurer C, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Reader J, Botha M, Dechering KJ, Sauerwein RW, Tungtaeng A, Vanachayangkul P, Lim CS, Burrows J, Witty MJ, Marsh KC, Bodenreider C, Rochford R, Solapure SM, Jiménez-Díaz MB, Wittlin S, Charman SA, Donini C, Campo B, Birkholtz L-M, Hanson KK, Drewes G, Kocken CHM, Delves MJ, Leroy D, Fidock DA, Waterson D, Street LJ, Chibale K. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017;9(387):eaad9735. doi:10.1126/scitranslmed.aad9735

Singh K, Okombo J, Brunschwig C, Ndubi F, Barnard L, Wilkinson C, Njogu PM, Njoroge M, Laing L, Machado M, Prudêncio M, Reader J, Botha M, Nondaba S, Birkholtz L-M, Lauterbach S, Churchyard A, Coertzer TL, Burrows JN, Yeates C, Denti P, Wiesner L, Egan TJ, Wittlin S, Chibale K. Antimalarial pyrido [1, 2-a] benzimidazoles: Lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and in vivo oral efficacy in a mouse model. Journal of medicinal chemistry. 2017;60(4):1432-48. doi:10.1021/acs.jmedchem.6b01641

Sungkapreecha C, Iqbal N, Gohn AM, Focke WW, Androsch R. Phase behavior of the polymer/drug system PLA/DEET. Polymer. 2017;126:116-25. doi:org/10.1016/j.polymer.2017.08.031

Tukei BB, Beke A, Lamadrid-Figueroa H. Assessing the effect of indoor residual spraying (IRS) on malaria morbidity in Northern Uganda: a before and after study. Malaria journal. 2017;16(1):4. doi:10.1186/s12936-016-1652-4

2016

Beteck RM, Coertzen D, Smit FJ, Birkholtz L-M, Haynes RK, N’Da DD. Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities. Bioorganic & medicinal chemistry letters. 2016;26(13):3006-9. doi:10.1016/j.bmcl.2016.05.024

Birkholtz L-M, Coetzer TL, Mancama D, Leroy D, Alano P. Discovering new transmission-blocking antimalarial compounds: challenges and opportunities. Trends in parasitology. 2016;32(9):669-81. doi:10.1016/j.pt.2016.04.017

Bornman M, Chevrier J, Rauch S, Crause M, Obida M, Sathyanarayana S, Barr D, Eskenazi B. Dichlorodiphenyltrichloroethane exposure and anogenital distance in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE) birth cohort study, South Africa. Andrology. 2016;4(4):608-15. 63. doi:10.1111/andr.12235

Braack L. Large contractors in Africa: conundrums with malaria chemoprophylaxis. Malaria journal. 2016;15(1):207. doi:org/10.1186/s12936-016-1265-y

Brisco KK, Cornel AJ, Lee Y, Mouatcho J, Braack L. Comparing efficacy of a sweep net and a dip method for collection of mosquito larvae in large bodies of water in South Africa. F1000Research. 2016;5. doi:10.12688/f1000research.8351.1

Diiro GM, Affognon HD, Muriithi BW, Wanja SK, Mbogo C, Mutero C. The role of gender on malaria preventive behaviour among rural households in Kenya. Malaria journal. 2016;15(1):14. doi:org/10.1186/s12936-015-1039-y

Goddard A, Leisewitz AL, Kjelgaard-Hansen M, Kristensen AT, Schoeman JP. Excessive pro-inflammatory serum cytokine concentrations in virulent canine babesiosis. PLoS One. 2016;11(3):e0150113. doi:10.1371/journal.pone.0150113

Le Manach C, Nchinda AT, Paquet T, Gonzàlez Cabrera D, Younis Y, Han Z, Bashyam S, Zabiulla M, Taylor D, Lawrence N, White KL, Charman SA, Waterson D, Witty MJ, Wittlin S, Botha ME, Nondaba SH, Reader J, Birkholtz L-M, Jiménez-Díaz MB, Martínez MS, Ferrer S, Angulo-Barturen I, Meister S, Antonova-Koch Y, Winzeler EA, Street LJ, Chibale K. Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle. Journal of medicinal chemistry. 2016;59(21):9890-905. doi:org/10.1021/acs.jmedchem.6b01265

Makhoba XH, Burger A, Coertzen D, Zininga T, Birkholtz L-M, Shonhai A. Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum s-adenosylmethionine decarboxylase protein produced in Escherichia coli. PloS one. 2016;11(3):e0152626. doi:10.1371/journal.pone.0152626

Moyo P, Botha M, Nondaba S, Niemand J, Maharaj VJ, Eloff JN, Louw AI, Birkholtz L. In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species. Journal of ethnopharmacology. 2016;185:235-42. doi:10.1016/j.jep.2016.03.036

Mpofu M, Becker P, Mudambo K, de Jager C. Field effectiveness of microbial larvicides on mosquito larvae in malaria areas of Botswana and Zimbabwe. Malaria journal. 2016;15(1):586. doi:org/10.1186/s12936-016-1642-6

Mwendera CA, de Jager C, Longwe H, Phiri K, Hongoro C, Mutero CM. Facilitating factors and barriers to malaria research utilization for policy development in Malawi. Malaria journal. 2016;15(1):512. doi:10.1186/s12936-016-1547-4

Mwendera C, de Jager C, Longwe H, Phiri K, Hongoro C, Mutero CM. Malaria research and its influence on anti-malarial drug policy in Malawi: a case study. Health Research Policy and Systems. 2016;14(1):41. doi:10.1186/s12961-016-0108-1

Patrick SM, Bornman MS, Joubert AM, Pitts N, Naidoo V, de Jager C. Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats. Reproductive Toxicology. 2016;61:19-27. doi:10.1016/j.reprotox.2016.02.015

Raman J, Morris N, Frean J, Brooke B, Blumberg L, Kruger P, Mabusa A, Raswiswi E, Shandukani B, Misani E, Groepe M-A, Moonasar D. Reviewing South Africa’s malaria elimination strategy (2012–2018): progress, challenges and priorities. Malaria journal. 2016;15(1):438. doi:org/10.1186/s12936-016-1497-x

Verlinden BK, Louw A, Birkholtz L-M. Resisting resistance: is there a solution for malaria? Expert opinion on drug discovery. 2016;11(4):395-406. doi:org/10.1517/17460441.2016.1154037

2015

Adeola AM, Botai JO, Olwoch JM, Rautenbach HCdW, Kalumba AM, Tsela PL, Adisa MO, Wasswa NF, Mmtoni P, Ssentongo A. Application of geographical information system and remote sensing in malaria research and control in South Africa: a review. Southern African Journal of Infectious Diseases. 2015;30(4):114-21. doi:org/10.1080/23120053.2015.1106765

Akhtar MU, Focke WW. Trapping citronellal in a microporous polyethylene matrix. Thermochimica Acta. 2015;613:61-5. doi:org/10.1016/j.tca.2015.06.003

Bouwman H, Bornman R, Van Dyk C, Barnhoorn I. First report of the concentrations and implications of DDT residues in chicken eggs from a malaria-controlled area. Chemosphere. 2015;137:174-7. doi:10.1016/j.chemosphere.2015.06.097

Braack L, Hunt R, Koekemoer LL, Gericke A, Munhenga G, Haddow AD, Becker P, Okia M, Kimera I, Coetzee M. Biting behaviour of African malaria vectors: 1. where do the main vector species bite on the human body? Parasites & vectors. 2015;8(1):76. doi:10.1186/s13071-015-0677-9

Burger PB, Williams M, Sprenger J, Reeksting SB, Botha M, Müller IB, Joubert F, Birkholtz L-M, Louw AI. A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail. Malaria journal. 2015;14(1):54. doi:10.1186/s12936-015-0572-z

Gaspar FW, Chevrier J, Bornman R, Crause M, Obida M, Barr DB, Bradman A, Bouwman H, Eskenazi B. Undisturbed dust as a metric of long-term indoor insecticide exposure: Residential DDT contamination from indoor residual spraying and its association with serum levels in the VHEMBE cohort. Environment international. 2015;85:163-7. doi:org/10.1016/j.envint.2015.09.014

Komen K, Olwoch J, Rautenbach H, Botai J, Adebayo A. Long-run relative importance of temperature as the main driver to malaria transmission in Limpopo Province, South Africa: A simple econometric approach. EcoHealth. 2015;12(1):131-43. doi:10.1007/s10393-014-0992-1

Kruger T, Sibanda MM, Focke WW, Bornman MS, de Jager C. Acceptability and effectiveness of a monofilament, polyethylene insecticide-treated wall lining for malaria control after six months in dwellings in Vhembe District, Limpopo Province, South Africa. Malaria journal. 2015;14(1):485. doi:10.1186/s12936-015-1005-8

Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz L-M, Meister S, Winzeler EA, Waterson D, Witty MJ, Wittlin S, Jiménez-Díaz M-B, Martínez MS, Ferrer S, Angulo-Barturen I, Street LJ, Chibale K. A novel pyrazolopyridine with in vivo activity in Plasmodium berghei-and Plasmodium falciparum-infected mouse models from structure–activity relationship studies around the core of recently identified antimalarial imidazopyridazines. Journal of medicinal chemistry. 2015;58(21):8713-22. doi:10.1021/acs.jmedchem.5b01605

Mutero CM, Mbogo C, Mwangangi J, Imbahale S, Kibe L, Orindi B, Girma M, Njui A, Lwande W, Affognon H. An assessment of participatory integrated vector management for malaria control in Kenya. Environmental health perspectives. 2015;123(11):1145-51. doi:10.1289/ehp.1408748

Paul C, Kramer R, Lesser A, Mutero C, Miranda ML, Dickinson K. Identifying barriers in the malaria control policymaking process in East Africa: insights from stakeholders and a structured literature review. BMC public health. 2015;15(1):862. doi:org/10.1186/s12889-015-2183-6

Reader J, Botha M, Theron A, Lauterbach SB, Rossouw C, Engelbrecht D, Wepener M, Smit A, Leroy D, Mancama D, Coetzer TL, Birkholtz L-M. Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination. Malaria journal. 2015;14(1):213. doi:org/10.1186/s12936-015-0718-z

Rossouw I, Maritz-Olivier C, Niemand J, Van Biljon R, Smit A, Olivier NA, Birkholtz L-M. Morphological and molecular descriptors of the developmental cycle of Babesia divergens parasites in human erythrocytes. PLoS Negl Trop Dis. 2015;9(5):e0003711. doi:10.1371/journal.pntd.0003711

Smit FJ, van Biljon RA, Birkholtz L-M, David DD. Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters. European journal of medicinal chemistry. 2015;90:33-44. doi:10.1016/j.ejmech.2014.11.016

Verlinden BK, De Beer M, Pachaiyappan B, Besaans E, Andayi WA, Reader J, Niemand J, Van Biljon R, Guy K, Egan T, Woster PM, Birkholtz L-M. Interrogating alkyl and arylalkylpolyamino (bis) urea and (bis) thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorganic & medicinal chemistry. 2015;23(16):5131-43. doi:org/10.1016/j.bmc.2015.01.036

2014

Birkholtz L-M, LeRoy D, Reader J, Botha M, Mancama D, Coetzer TL. Differential activity of novel gametocytocidal compounds: drug mode-of-action and ex vivo efficacy. Malaria Journal. 2014;13(S1):P13. doi:org/10.1186/1475-2875-13-S1-P13

Eskenazi B, Quirós-Alcalá L, Lipsitt JM, Wu LD, Kruger P, Ntimbane T, Nawn JB, Bornman MR, Seto E. mSpray: A mobile phone technology to improve malaria control efforts and monitor human exposure to malaria control pesticides in Limpopo, South Africa. Environment international. 2014;68:219-26. doi:10.1016/j.envint.2014.03.003

Munhenga G, Brooke BD, Spillings B, Essop L, Hunt RH, Midzi S, Govender D, Braack L, Koekemoer LL. Field study site selection, species abundance and monthly distribution of anopheline mosquitoes in the northern Kruger National Park, South Africa. Malaria journal. 2014;13(1):27. doi:org/10.1186/1475-2875-13-27

Mutero CM, Kramer RA, Paul C, Lesser A, Miranda ML, Mboera LE, Kiptui R, Kabatereine N, Ameneshewa B. Factors influencing malaria control policy-making in Kenya, Uganda and Tanzania. Malaria journal. 2014;13(1):1-10. doi:org/10.1186/1475-2875-13-305

Le Roux D, Burger PB, Niemand J, Grobler A, Urbán P, Fernàndez-Busquets X, Barker RH, Serrano AE, Louw AI, Birkholtz L-M. Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites. International Journal for Parasitology: Drugs and Drug Resistance. 2014;4(1):28-36. doi:10.1016/j.ijpddr.2013.11.003

Saïdani N, Botté CY, Deligny M, Bonneau A-L, Reader J, Lasselin R, Merer G, Niepceron A, Brossier F, Cintrat J-C, Rousseau B, Birkholtz L-M, Cesbron-Delauw M-F, Dubremetz J-F, Mercier C, Vial H, Lopez R, Maréchala E. Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs. Antimicrobial agents and chemotherapy. 2014;58(5):2586-97. doi:10.1128/AAC.01445-13

Strydom K-A, Ismail F, Frean J. Plasmodium ovale: a case of not-so-benign tertian malaria. Malaria journal. 2014;13(1):85. doi:org/10.1186/1475-2875-13-85

Whitworth KW, Bornman RM, Archer JI, Kudumu MO, Travlos GS, Wilson RE, Longnecker MP. Predictors of plasma DDT and DDE concentrations among women exposed to indoor residual spraying for malaria control in the South African Study of Women and Babies (SOWB). Environmental health perspectives. 2014;122(6):545-52. doi:10.1289/ehp.1307025

2013

Bouwman H, Bornman R, van den Berg H, Kylin H. DDT: fifty years since Silent Spring. 2013. doi:10.2800/70069

Morris N, Frean J, Baker L, Ukpe IS, Barnes K, Kruger P, Mabuza A, Raswiswi E, Maharaj R, Blumberg L. Re-defining the extent of malaria transmission in South Africa: implications for chemoprophylaxis. South African Medical Journal. 2013;103(11):858-60. doi:10.7196/SAMJ.7533

Mpangase PT, Szolkiewicz MJ, Le Grange M, Smit JH, Burger PB, Joubert F. Discovery-2: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria. Malaria Journal. 2013;12(1):1-9. doi:10.1186/1475-2875-12-116

Niemand J, Burger P, Verlinden BK, Reader J, Joubert AM, Kaiser A, Louw AI, Kirk K, Phanstiel O, Birkholtz L-M. Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites. Antimicrobial agents and chemotherapy. 2013;57(6):2874-7. doi:10.1128/AAC.00106-13

Reeksting SB, Müller IB, Burger PB, Burgos ES, Salmon L, Louw AI, Birkholtz L-M, Wrenger C. Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum. Biochemical Journal. 2013;449(1):175-87. doi:10.1042/BJ20120925

Ukpe IS, Moonasar D, Raman J, Barnes K, Baker L, Blumberg L. Case management of malaria: treatment and chemoprophylaxis. South African Medical Journal. 2013;103(10):793-8. doi:10.7196/samj.7443

2012

Birkholtz L-M, Bornman R, Focke W, Mutero C, de Jager C. Sustainable malaria control: Transdisciplinary approaches for translational applications. Malaria Journal. 2012;11(431). doi.org/10.1186/1475-2875-11-431