Research Projects

ECOG E2108 – A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients with Metastatic Breast Cancer.

The primary objective is to evaluate whether early therapy of intact primary disease in women with stage IV breast cancer whose disease does not progress during initial optimal systemic therapy, will result in prolonged survival, compared to women who receive local therapy for palliation only.  Currently we have one successfully identified patient on this trial.


International Atomic Energy Agency conducted a randomized multicentre trial of accelerated hypo – vs normo – fractionated radiotherapy for head and neck squamous cell carcinoma (HYPNO trial).

The Purpose of the present study is to improve the effect of radiotherapy given to patients with head and neck carcinoma, who are candidates for primary radiotherapy alone.  The study will evaluate the loco-regional tumor control after radiotherapy, disease-free and overall survival, and the early and late treatment related morbidity.  The protocol intends to exclude a minimum of patients to get a true impression of the suitability of such therapy in an unselected patient population in a global environment.


International Atomic Energy Agency – “Resource – Sparing Curative Treatment for Rectal Cancer”

This is a prospective, multi-centre, phase-III-randomized, clinical trial. It compares two different neo-adjuvant radiation-based strategies for locally advanced Adenocarcinoma of the rectum (LARC) prior to possible surgery. The abbreviation LARC in this protocol encompasses two types of clinical situations. First, a patient can be “at-risk” for a positive circumferential resection margin (at-risk for pCRM+) on baseline assessment-imaging. Second, a patient can be identified as being with T-descriptor of T4 (i.e. cT4 or uT4) from baseline assessment (See Appendix 1 for staging information).


MVCBCT FOX  expansion,
Prof A van Rensburg

IMRT Quality Assurance,
Prof A van Rensburg

Electron Field shaping,
Prof A van Rensburg

Brachytherapy seed design,
Prof A van Rensburg

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