Lynne Pilcher

Prof LA Pilcher

Tel:             +27 (0)12-420-5384

Email:         [email protected]

Office:        Room 1-35 Chemistry Bld

Position:     Associate Professor

Academic qualifications: MSc (Rhodes), PhD (Cambridge)

NRF rating:   C2

 

Teaching

Organic chemistry from first year to honours depending on the lecture assignment in a particular year.  Care is taken to integrate the theory taught and the practical training.

Modules: CMY 127, 151, 284, 708 and 709

Awards

In 2019 Lynne Pilcher was recognized as the best lecturer in the physical sciences cluster; in 2017, she was awarded the SACI Chemistry Education medal; and in 2014 she received the prestigious UP Laureate Award for Teaching Excellence and Innovation together with two co-workers for redesigning the third year organic chemistry practical curriculum to train undergraduate students to become researchers. 

Research Interests

Lynne Pilcher is leading tertiary chemistry education research projects.  Current projects include (1) self-regulated learning in first-year chemistry in the online environment and (2) incorporating systems thinking in Chemistry education with a focus on organic chemistry.  These projects build on ongoing projects in the use of blended learning in first- and second-year organic chemistry.

As an established researcher in synthetic organic chemistry, Lynne Pilcher’s education research builds on an understanding of what is required of a skilled organic chemist. She is still involved in the supervision of projects in organic synthesis for solving biological problems.  Lynne Pilcher’s research is not limited to a particular class of organic compounds and as new target molecules were identified the relevant practicalities of doing chemistry with a new class of compounds had to be learnt.  This wide organic research area together with training in natural products chemistry (MSc, Rhodes, 1996), stereoselective synthesis (PhD, Cambridge, 2000) and enzyme mechanisms (Postdoc, Brown, 2001-2), has provided a sound background for the teaching of organic chemistry and for her current research in tertiary chemistry education.

Organic chemistry projects have included (1) the synthesis of mycolic acids – the wax esters from the cell wall of M.Tb – in collaboration with Verschoor (Biochemistry) to develop TB diagnostics, (2) the synthesis and mechanistic studies on the reactions of purine compounds with a view to elucidating the role of adenine in kinase reaction mechanisms and (3) the improvement of existing TB, HIV and Malaria drugs through nanomedicine in collaboration with Balogun (CSIR).

Please visit our Tertiary Chemistry Education research group website.

Publications

Recent Journal Articles

Fru *, P. N.; Nweke, E.; Mthimkhulu, N.; Mvango, S; Nel, M.; Pilcher, L.A.; Balogun M.O. “Anti-Cancer and Immunomodulatory Activity of a Polyethylene Glycol-Betulinic Acid Conjugate on Pancreatic Cancer Cells” Life, 2021, accepted.

Khazir, J.; Mir, B.A.; Chashoo, G.; Pilcher L.A.; Riley, D. Synthesis and anti-cancer activity of N-9- and N-7- substituted 1,2,3-triazole analogues of 2,6-di-substituted purine.  Medicinal Chemistry Research 2020, 29(1), 33-45.

Tshweu, L.L.; Shemis, M.A.; Abdelghany, A.; Gouda, A.; Pilcher, L.A.; Sibuyi, N.R.S.; Meyer, M.; Dube, A.; Balogun, M.O. “Synthesis, physicochemical characterization, toxicity and efficacy of a PEG conjugate and a hybrid PEG conjugate nanoparticle formulation of the antibiotic moxifloxacin” RSC Advances, 2020, 10, 19770.

Khazir, J.; Mir, B.A.; Chashoo, G.; Maqbool, T.; Riley, D.; Pilcher L.A. “Design, Synthesis and anticancer evaluation of Acetamide and Hydrazine analogues of Pyrimidine” J. Heterocyclic. Chem. 2020, 57(3), 1306-1318. https://doi.org/10.1002/jhet.3867

Mvango, S.; Mthimkhulu, N.; Fru, P.N.; Pilcher, L.A.; Balogun, M.O. Physico-Chemical Characterization of Polyethylene Glycol-Conjugated Betulinic Acid. AIP Conference Proceedings 2020, 2289, 020039, doi:10.1063/5.0028479.

Tekane, R.; Pilcher, L. A.; Potgieter, M. “Blended learning in a second year organic chemistry class: students’ perceptions and preferences of the learning support.” Chem. Educ. Res. Pract., 2020, 21, 24-36. DOI: 10.1039/c9rp00099b.

Potgieter, M.; Pilcher, L.A.; Tekane, R.R.; Louw, I.; Fletcher, L. “Chapter 6: Lessons learnt from teaching and learning during disruptions” in Research and Practice in Chemistry Education, Ed Schultz, M, Schmid, S, Lawrie, G.A., Springer, 2019, DOI: 10.1007/978-981-13-6998-8_6

Mvango, S., Matshe, W. M. R., Balogun, A. O. Pilcher, L. A.; Balogun, M. O. “Nanomedicines for Malaria Chemotherapy: Encapsulation vs. Polymer Therapeutics” Pharm Res (2018) 35: 237. https://doi.org/10.1007/s11095-018-2517-z

Buyens, D. M. S.; Mangondo, P.; Cukrowski, I.; Pilcher, L. A.* “Solvent directed regioselective benzylation of adenine: characterization of N9- and N3-benzyladenine.”J. Heterocyclic. Chem. 2017, 54(5), 2946–2950.  DOI: 10.1002/jhet.2894, published online 3 May 2017.

Khazir, J.; Mir, B. A.; Pilcher, L. A.; Riley, D. L.; Chasoo, G.; Islam, M.A.; Saxena, A.; Sampath Kumar, H. M. “Design and synthesis of ring C opened analogues of α-santonin as potential anticancer agents" Med. Chem. Res., 2016, 25, 2030-2041. DOI: 10.1007/s00044-016-1633-8

Pilcher, L. A.; Riley, D. L.; Mathabathe, K. C.; Potgieter, M. “An inquiry-based practical curriculum for organic chemistry as preparation for industry and postgraduate research” S. Afr. J. Chem., 2015, 68, 236-244.

Khazir, J.; Riley, D. L.; Chashoo, G.; Mir, B. A.; Liles, D.; Islam, M. A.; Singh, S. K.; Vishwakarma, R. A.;   Pilcher, L. A.  “Design, synthesis and anticancer activity of Michael-type thiol adducts of α-santonin analogue with exocyclic methylene”, Eur. J. Med. Chem., 2015, 101, 769–779.

Khazir, J.; Riley, D. L.; Pilcher, L. A.; De Maayer, P.; Mir, B. A.  “Anticancer agents from diverse natural sources” Nat. Prod. Commun. 2014, 9(11), 1655-1669.

Khazir, J.; Mir, B. A.; Pilcher, L.; Riley, D. L.  “Role of plants in anticancer drug discovery” Phytochemistry Lett. 2014, 7, 173-181.

Balogun, M.O.; Huws, E.; Sirhan, M.M.; Saleh, A.D.;  Al Dulayymi, J.R.; Pilcher, L.; Verschoor, J.A.; Baird, M.S. “Thiol modified mycolic acids”, Chemistry and Physics of Lipids 2013, 172-173, 40-57.

Beukes, M.; Lemmer, Y.; Deysel, M.; Al Dulayymi, J.R.; Baird, M.S.; Koza, G. Iglesias, M.M.; Rowles, R.R.; Theunissen, C.; Grooten, J.; Toschi, G.; Roberts, V.V.; Pilcher, L.; van Wyngaardt, S.; Mathebula, N.; Balogun, M.; Stoltz, A.C.; Verschoor, J.A. “Structure-function relationships of the antigenicity of mycolic acids in tuberculosis patients” Chemistry and Physics of Lipids 2010, 163, 800-808.

Driver, C. H. S.; Balogun, M. O.; Toschi, G.; Verschoor, J. A.; Baird, M. S.;, Pilcher, L. A.*  “A biomimetic approach to the synthesis of a mycolic motif” Tetrahedron Lett. 2010, 51, 1185-1186.

Lemmer, Y.; Thanyani, S.T.; Vrey, P.J.; Driver, C.H.S.; Venter, L.; van Wyngaardt, S.; Ten Bokum, A.M.C.; Ozoemena, K.I.; Pilcher, L.A.; Fernig, D.G.; Stoltz, A.C.; Swai. H.S.; Verschoor, J.A. “Chapter 5 – Detection of anti-mycolic acid antibodies by liposomal biosensors” Methods Enzymol, 2009, 464, 79-104.

Sharma, K.; Laurens J.B.; Pilcher, L.A.* “Stereoselective synthesis of the urinary metabolite N-Acetyl-S-(3,4-dihydroxybutyl)cysteine”  Synth. Commun. 2009, 39, 1415-1424.

Benadie, Y.; Deysel, M.; Siko, D.G.R.; Roberts, V.V.; van Wyngaardt, S.; Thanyani, T.S.; Sekanka, G.; Ten Bokum, A.M.C.; Collett, L.A.; Grooten, J.; Baird, M.S.; Verschoor, J.A. “Cholesteroid Nature of Free Mycolic Acids from M. tuberculosis.” Chemistry and Physics of Lipids 2008, 152, 95-103.

Paterson, I.; Collett, L.A.  “Remote 1,5-stereoinduction in boron aldol reactions of methyl ketones: application to the convergent assembly of the 1,3-polyol sequence of (+)-roxaticin”  Tetrahedron Lett., 42, 2001, 1187-1191.

Brecknell, D.J.; Collett, L.A.; Davies-Coleman, M.T.; Garson, M.J.; Jones, D.D.  "New non-contiguous polypropionates from marine moluscs: A comment on their natural product status"  Tetrahedron, 56, 2000, 2497-2502.

Collett, L.A.; Davies-Coleman, M.T.; Rivett, D.E.A.  "5,6-dihydro- a-pyrones from Syncolostemon argenteus"  Phytochemistry, 48, 1998, 651-656.

Collett, L.A.; Davies-Coleman, M.T.; Rivett, D.E.A.  "Naturally occurring 6-substituted-5,6-dihydro- a-pyrones"  Fortschr. Chem. Organ. Naturstoffe, 75, 1998, 181-209.

Collett, L.A.; Brown, M.E.  "Biochemical and Biological Applications of Thermal Analysis"  J. Thermal Analysis, 51, 1998, 693-726.

Collett, L.A.; Davies-Coleman, M.T.; Rivett, D.E.A.; Drewes, S.E.; Horn, M.M. "Absolute configuration of a-pyrones from Cryptocarya latifolia and Syncolostemon densiflorus"  Phytochemistry, 44, 1997, 935-938.

- Author Lynne Pilcher
Published by Anita Botha

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