The HSPC & Haematopoiesis research team focuses on understanding haematopoiesis in the context of HIV infection, and the expansion and transduction of HSPCs (haematopoietic stem and progenitor cells) for cell and gene therapy purposes. This research team partially falls under the umbrella of the South African Medical Research Council (SAMRC) Extramural Stem Cell Unit (more information available from https://www.samrc.ac.za/extramural-research-units/stem-cell-research-and-therapy) and operates under the guidance of Professor Michael S. Pepper and Dr Chrisna Durandt.
| Project topic/title | Project leader/student | Ethics reference number |
|---|---|---|
| Correlation between haematopoiesis-associated cytokine plasma levels, immature circulating hematopoietic cell frequency and the presence and severity of haematological abnormalities in a treatment-naive, HIV-positive cohort |
Dr Chrisna Durandt (Senior researcher) Tsungai Mashingaidze (MSc student) |
664/2019 |
| Immature circulating haematopoietic cells, haematopoiesis-associated cytokine plasma levels and the haematological profile in a treatment-naive HIV-positive cohort |
Dr Chrisna Durandt (Senior researcher) Tsungai Mashingaidze (MSc student) |
SMUREC/M/86/202:IR UP: 738/2020 |
| Haematopoietic stem and progenitor cell heterogeneity and susceptibility to HIV-1 |
Dr Juanita Mellet (Post-doctoral fellow) |
410/2014 |
| Anti-HIV lentivector transduction of primary haematopoietic stem, progenitor, and T-cells |
Candice Herd (PhD student) |
42/2020 |
| Characterisation of umbilical cord blood derived haematopoietic stem and progenitor cells from HIV exposed infants that are HIV negative at birth |
Dr Candice Hendricks (PhD student) |
102/2020 |
| Investigating the direct infection of ex vivo bone marrow-derived and peripheral blood-derived haematopoietic stem/progenitor cells by HIV-1 |
Priyal Mistry (MSc student) |
396/2021 |
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