The goal of the NESHIE (Neonatal Encephalopathy with Suspected Hypoxic Ischaemic Encephalopathy) group is to identify genetic determinants and biomarkers of NESHIE in a multidisciplinary, cross-country South African cohort under the leadership of Professor Michael S. Pepper. Future directions include clinical trials of neuroprotective agents as expanded treatment options. The NESHIE research effort is funded by the Bill and Melinda Gates Foundation; the details of the grant are available at

Project topic/title

Project leader/student

Ethics reference number

Is there a genetic predisposition to death and disability after moderate-severe NESHIE in cooled infants? A multi-factorial, multi-centre study in a South African cohort

Prof Michael S Pepper


Jeanne van Rensburg

(Project manager)

Dr Juanita Mellet

(post-doctoral fellow)


The development and design of a highly discerning platform for data capture in a neonatal encephalopathy study

Thumbiko Teeks Kalua 

(MSc student)


Identification of allelic variants implicated in NESHIE and consequential cerebral palsy in individuals of African origin 

Megan Ryder

(MSc student)



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