NESHIE

The goal of the NESHIE (Neonatal Encephalopathy with Suspected Hypoxic Ischaemic Encephalopathy) group is to identify genetic determinants and biomarkers of NESHIE in a multidisciplinary, cross-country South African cohort under the leadership of Professor Michael S. Pepper. Future directions include clinical trials of neuroprotective agents as expanded treatment options. The NESHIE research effort is funded by the Bill and Melinda Gates Foundation; the details of the grant are available at https://www.gatesfoundation.org/about/committed-grants/2021/02/inv022216.

Project topic/title	Project leader/student	Ethics reference number
Is there a genetic predisposition to death and disability after moderate-severe NESHIE in cooled infants? A multi-factorial, multi-centre study in a South African cohort	Prof Michael S Pepper (Director) Jeanne van Rensburg (Project manager) Dr Juanita Mellet (post-doctoral fellow)	481/2017
The development and design of a highly discerning platform for data capture in a neonatal encephalopathy study	Thumbiko Teeks Kalua (MSc student)	739/2020
Identification of allelic variants implicated in NESHIE and consequential cerebral palsy in individuals of African origin	Megan Ryder (MSc student)	361/2021

Project topic/title

Project leader/student

Ethics reference number

Is there a genetic predisposition to death and disability after moderate-severe NESHIE in cooled infants? A multi-factorial, multi-centre study in a South African cohort

Prof Michael S Pepper

(Director)

Jeanne van Rensburg

(Project manager)

Dr Juanita Mellet

(post-doctoral fellow)

481/2017

The development and design of a highly discerning platform for data capture in a neonatal encephalopathy study

Thumbiko Teeks Kalua

(MSc student)

739/2020

Identification of allelic variants implicated in NESHIE and consequential cerebral palsy in individuals of African origin

Megan Ryder

(MSc student)

361/2021

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