Publication List

2022

Regenerative medicines: A new regulatory paradigm for South Africa

Viljoen IM, Hendricks CL, Malherbe HL, Pepper MS

https://doi.org/10.1016/j.biochi.2022.02.010

High Resolution HLA ∼A, ∼B, ∼C, ∼DRB1, ∼DQA1, and ∼DQB1 Diversity in South African Populations

Tshabalala M, Mellet J, Vather K, Nelson D, Mohamed F, Christoffels A and Pepper MS

https://doi.org/10.3389/fgene.2022.711944


 

SARS-CoV-2 Variants, Vaccines, and Host Immunity

Mistry P, Barmania F, Mellet J, Peta K, Strydom A, Viljoen IM, James W, Gordon S, Pepper MS

doi: 10.3389/fimmu.2021.809244

MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma

Setlai BP, Hull R, Reis RM, Agbor C, Ambele MA, Mulaudzi TV, Dlamini Z

https://doi.org/10.3390/genes13020244

Mesenchymal Stromal Cells: a Possible Reservoir for HIV-1?

Kallmeyer K, Ryder MA, Pepper MS

https://doi.org/10.1007/s12015-021-10298-5

Equitable access to cell and gene therapies in South Africa: opportunities and hurdles

Hendricks CL, Alessandrini M, Pepper MS

https://doi.org/10.1038/s41434-021-00309-y

The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells

Damerell V, Ambele MA, Salisbury S, Neumann-Mufweba A, Durandt C, Pepper MS and Prince S

https://doi.org/10.3389/fonc.2021.801691

Slc7a8 Deletion Is Protective against Diet-Induced Obesity and Attenuates Lipid accumulation in Multiple Organs

Pitere RR, van Heerden MB, Pepper MS, Ambele MA

https://doi.org/10.3390/biology11020311

2021

The impact of obesity on the cellular and molecular pathophysiology of COVID-19

Dhanraj P, Pitere R, Pepper MS

https://doi.org/10.7196/SAMJ.2021.v111i2.15398

The COVID-19 Treatment Landscape: A South African Perspective on a Race Against Time

Hendricks CL, Herd C, Nel M, Tintinger G and Pepper MS

https://doi.org/10.3389/fmed.2021.604087

Step-by-step assembly and testing of a low-cost bioprinting solution for research and  educational purposes

Honiball JR, Pepper MS, Prinsloo E

https://doi.org/10.1016/j.mex.2020.101186

Spectrum of MYO7A Mutations in an Indigenous South African Population Further Elucidates the Nonsyndromic Autosomal Recessive Phenotype of DFNB2 to Include Both Homozygous and Compound Heterozygous Mutations

Kabahuma RI, Schubert WD, Labuschagne C, Yan D, Blanton SH, Pepper MS, Liu XZ

https://doi.org/10.3390/genes12020274

A COVID-19 Vaccine: Big Strides Come with Big Challenges

Mellet J, Pepper MS

https://doi.org/10.3390/

vaccines9010039

Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues which Reversibly Depolymerize Microtubules

Mercier AE, Prudent R, Pepper MS, De Koning L, Nolte E, Peronne L, Nel M, Lafanechère L, Joubert AM

https://doi.org/10.3390/molecules26030706

Advancing global equity in cancer genomics - challenges and opportunities in Sub-Saharan Africa

Munung NS, Ambele MA, Moela P

https://doi.org/10.1016/j.gde.2020.11.006

2020

Contact tracing during the COVID-19 pandemic: Protection of personal information in South Africa

Viljoen IM, de Villebois Castelyn C, Pope A, Botes M, Pepper MS

https://doi.org/10.7196/SAJBL.2020.v13i1.718

Barriers to Implementing Clinical Pharmacogenetics Testing in Sub-Saharan Africa. A Critical Review

Tata EB, Ambele MA, Pepper MS

https://doi.org/10.3390/pharmaceutics12090809

CORRESPONDENCE: Privacy rights of human research participants in South Africa must be taken seriously

Staunton C, Adams R, Botes M, Dove ES, Horn L, Labuschaigne M, Loots G, Mahomed S, Olckers A, Pepper MS, Pope A, Ramsay M, Loideain NN, de Vries J

https://doi.org/10.7196/SAMJ.2020.v110i3.14450

Precision global health: a roadmap for augmented action

Sheath DJ, Ruiz de Castañeda R, Bempong NE, Raviglione M, Machalaba C, Pepper MS, Vayena E, Ray N, Wernli D, Escher G, Grey F, Elger BS, Kleineberg KK, Beran D, Miranda JJ, Huffman MD, Hersch F, Andayi F, Thumbi SM, D’Acremont V, Hartley MA, Zinsstag J, Larus J, Rodríguez Martínez M, Guerin PJ, Merson L, Ngyuen VK, Rühli F, Geissbuhler A, Salathé M, Bolon I, Boehme C, Berkley S, Valleron AJ, Keiser O, Kaiser L, Eckerle I, Utzinger J, Flahault A.

https://doi.org/10.21037/jphe.2020.01.01

Access to novel therapies for COVID-19 – distributive justice and Russian roulette?

Pepper MS

https://doi.org/10.7196/SAMJ.2020.v110i12.15362

Balancing privacy with public health: How well is South Africa doing?

Pepper MS, Botes M, Pope A, Castelyn C, Viljoen IM

https://theconversation.com/balancing-privacy-with-public-health-how-well-is-south-africa-doing-140759

Research in COVID-19 times: The way forward

Pepper MS, Burton SG

https://doi.org/10.7196/SAMJ.2020.v110i8.15053

Sheer volume of misinformation risks diverting focus from fighting coronavirus

Pepper MS, Burton SG

https://theconversation.com/sheer-volume-of-misinformation-risks-diverting-focus-from-fighting-coronavirus-137408

The African Genomic Medicine Training Initiative (AGMT): Showcasing a Community and Framework Driven Genomic Medicine Training for Nurses in Africa

Nembaware V, Mulder N

https://doi.org/10.3389/fgene.2019.01209

Rapid evolution of our understanding of the pathogenesis of COVID-19 - implications for therapy

Mustafa F, Giles R, Pepper MS

https://doi.org/10.7196/SAMJ.2020.v110i12.15328

The Deep Genome Project

Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD

Herault Y, de Angelis MH, Lupski JR, Lyonnet S, Mallon A-M, Mammano F, MacRae CA, McInnes R, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang C-KL, Wells S, White J, Wurst W, Xu Y, Brown SDM

https://doi.org/10.1186/s13059-020-1931-9

Fate of systemically and locally administered adipose-derived mesenchymal stromal cells and their effect on wound healing

Kallmeyer K, André-Lévigne D, Baquié M, Krause K-H, Pepper MS, Pittet-Cuénod B, Modarressi A

https://doi.org/10.1002/sctm.19-0091

Paediatric inflammatory multisystem syndrome: What should we look out for in South Africa?

Hendricks CL, Mustafa F, Green RJ, Pepper MS

https://doi.org/10.7196/SAMJ.2020.v110i9.15062

COVID-19 in children: Should we be worried?

Hendricks CL, Green RJ

https://doi.org/10.7196/SAMJ.2020.v110i9.15023

Lessons Learned from Somatic Cell Nuclear Transfer

Gouveia C, Huyser C, Egli D, Pepper MS

https://doi.org/10.3390/ijms21072314

The impact of obesity on the cellular and molecular pathophysiology of COVID-19

Dhanraj P, Pitere R, Pepper MS

https://doi.org/10.7196/SAMJ.2021.v111i2.15398

The Role of Pref-1 during Adipogenic Differentiation: An Overview of Suggested Mechanisms

da Silva C, Durandt C, Kallmeyer K, Ambele MA, Pepper MS

https://doi.org/10.3390/ijms21114104

Non-COVID-19 Patients Left out in the Cold Inevitable Outcome of Pandemic Ethics?

Castelyn C

https://doi.org/10.7916/vib.v6i.6198

Resource allocation during COVID-19: A focus on vulnerable populations

de V Castelyn C, Viljoen IM, Dhai A, Pepper MS

https://doi.org/10.7196/SAJBL.2020.v13i2.730

Lockdowns and research: what we lost and what we stand to gain

Burton SG, Pepper MS

https://theconversation.com/lockdowns-and-research-what-we-lost-and-what-we-stand-to-gain-138355

A prospective observational study of developmental outcomes in survivors of neonatal hypoxic ischaemic encephalopathy in South Africa

Ballot DE, Rakotsoane D, Cooper PA, Ramdin TD, Chirwa T, Pepper MS

https://doi.org/10.7196/SAMJ.2020.v110i4.14311

Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways

Ambele MA, Dhanraj P, Giles R, Pepper MS

https://doi.org/10.3390/ijms21124283

Amplification of 3q26.2, 5q14.3, 8q24.3, 8q22.3, and 14q32.33 Are Possible Common Genetic Alterations in Oral Cancer Patients

Ambele MA, van Zyl A, Pepper MS, van Heerden MB and van Heerden WFP

https://doi.org/10.3389/fonc.2020.00683

2019

Cell and gene therapies at the forefront of innovative medical care: Implications for South Africa

Pepper MS, Alessandrini M, Pope A, van Staden W, Green RJ

https://doi.org/10.7196/SAMJ.2019.v109i1.13425

Heterogeneity of cell therapy products

Wolmarans E, Mellet J, Ambele MA, Durandt C, Pepper MS

https://doi.org/10.7196/SAMJ.2019.v3109i8b.13822

Establishment and equilibrium levels of deleterious mutations in large populations

Viljoen JW, de Villiers JP, van Zyl AJ, Mezzavilla M, Pepper MS

https://doi.org/10.1038/s41598-019-46803-7

Safeguarding the future of genomic research in South Africa: Broad consent and the Protection of Personal Information Act No. 4 of 2013

Staunton C, Adams R, Botes M, Dove ES, Horn L, Labuschaigne M, Loots G, Mahomed S, Makuba J, Olckers A, Pepper MS, Pope A, Ramsay M, Loideain NN, de Vries J

https://doi.org/10.7196/SAMJ.2019.v109i7.14148

Stem cell tourism and spinal cord injury in South Africa

Skeen M, Eksteen CA, Pepper MS

https://doi.org/10.7196/SAMJ.2019.v109i8b.13824

An optimistic vision for biosciences in South Africa: Reply to Thaldar et al. (2019)

Pepper MS, Dandara C, de Vries J, Dhai A, Labuschaigne M, Mnyongani F, Moodley K, Olckers A, Pope A, Ramesar R, Ramsay M, Towers W

https://doi.org/10.17159/sajs.2019/a0312

Special edition of the SAMJ devoted to cell and gene therapy

Pepper MS

https://doi.org/10.7196/SAMJ.2019.v109i8b.14328

The African Genomic Medicine Training Initiative (AGMT): Showcasing a Community and Framework Driven Genomic Medicine Training for Nurses in Africa

Nembaware V, Mulder N

https://doi.org/10.3389/fgene.2019.01209

Human leukocyte antigen (HLA) diversity and clinical applications in South Africa

Mellet J,Tshabalala M, Agbedare O, Meyer PWA, Gray CM, Pepper MS

https://doi.org/10.7196/SAMJ.2019.v109i8b.13825

Non-nucleoside reverse transcriptase inhibitor levels among HIV-exposed uninfected infants at the time of HIV PCR testing – findings from a tertiary healthcare facility in Pretoria, South Africa

Mazanderani AH, Murray TY, Sherman GG, Snyman T, George J, Avenant T, Goga AE, Pepper MS, du Plessis N

https://doi.org/10.1002/jia2.25284

Fate of systemically and locally administered adipose‐derived mesenchymal stromal cells and their effect on wound healing

Kallmeyer K, André-Lévigne D, Baquié M, Krause KH, Pepper MS, Pittet-Cuénod B, Modarressi A

https://doi.org/10.1002/sctm.19-0091.

Haematopoietic stem cell transplantation in South Africa: Current limitations and future perspectives

Grobbelaar S, Mercier AE, Verburgh E, Brittain D, Pepper MS

https://doi.org/10.7196/SAMJ.2019.v109i8b.13888

Primary immunodeficiency in Africa – a review

Erjaee A, Bagherpour M, van Rooyen C, van den Berg S, Kinnear CJ, Green RJ, Pepper MS

https://doi.org/10.7196/SAMJ.2019.v109i8b.13820

Gene and cell therapy in South Africa: Current status and future prospects

Ely A, Bloom K, Maepa MB, Mahlangu JN, Pepper MS, Arbuthnot P

https://doi.org/10.7196/SAMJ.2019.v109i8b.13819

The Efect of Early Rounds of ex vivo Expansion and Cryopreservation on the Adipogenic Diferentiation Capacity of Adipose-Derived Stromal/Stem Cells

Durandt C, Dessels C, da Silva C, Murdoch C, Pepper MS

https://doi.org/10.1038/s41598-019-52086-9

HIV and haematopoiesis

Durandt C, Potgieter JC, Mellet J, Herd C, Khoosal R, Nel JG, Rossouw T, Pepper MS

https://doi.org/10.7196/SAMJ.2019.v109i8b.13829

An Early Infant HIV Risk Score for Targeted HIV Testing at Birth

Du Plessis NM, Muller CJB, Avenant T, Pepper MS, Goga AE

https://doi.org/10.1542/peds.2018-3834

The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro

Dessels C, Ambele MA, Pepper MS

https://doi.org/10.1186/s13287-019-1370-2

Comparison of human platelet lysate alternatives using expired and freshly isolated platelet concentrates for adipose-derived stromal cell expansion

Dessels C, Durandt C, Pepper MS

https://doi.org/10.1080/09537104.2018.1445840

Reference Gene Expression in Adipose-Derived Stromal Cells Undergoing Adipogenic Differentiation

Dessels C, Pepper MS

https://doi.org/10.1089/ten.tec.2019.0076

Molecular Profile of Tongue Cancer in an 18-Year-Old Female Patient With No Recognizable Risk Factor

Ambele MA, Pepper MS, van Heerden MB, van Heerden WFP

https://doi.org/10.1002/lio2.266

Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations

Ambele MA, Pepper MS, van Heerden MB, van Heerden WFP

https://doi.org/10.1002/hed.25566

Transplantation of gene-modified haematopoietic stem cells: Application and clinical considerations

Alessandrini M, Krause KH, Speck RF, Pepper MS

https://doi.org/10.7196/SAMJ.2019.v109i8b.13910

Stem cell therapy for neurological disorders

Alessandrini M, Preynat-Seauve O, de Bruin K, Pepper MS

https://doi.org/10.7196/SAMJ.2019.v109i8b.14009

2018

Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations

Wolmarans E, Nel S, Durandt C, Mellet J, Pepper MS

https://doi.org/10.1155/2018/2472137

Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry

Tshabalala M, Ingram C, Schlaphoff T, Borrill V, Christoffels A, Pepper MS

https://doi.org/10.1155/2018/2031571

Genome technologies, precision medicine and innovative therapies

Pepper MS

http://hdl.handle.net/2263/68527

Ethical considerations in the application of cell and gene therapies in children

Pepper MS, Pope A, Kling S, Alessandrini M, van Staden W, Green RJ

https://doi.org/10.7196/SAMJ.2018.v108i12.13585

ASSAf consensus study on the ethical, legal and social implications of genetics and genomics in South Africa

Pepper MS, Dandara C, de Vries J, Dhai A, Labuschaigne M, Mnyongani F, Moodley K, Olckers A, Pope A, Ramesar R, Ramsay R, Soodyall H, Towers W

https://dx.doi.org/10.17159/sajs.2018/a0302

African scientists call for more control of their continent’s genomic data

Nordling L

https://doi.org/10.1038/d41586-018-04685-1

South Africa’s science academy urges update to nation’s genetics laws

Wild S

https://doi.org/10.1038/d41586-018-07637-x

Strategies for screening cord blood for a public cord blood bank in high HIV prevalence regions

Meissner-Roloff M, Gaggia L, Vermeulen M, Mazanderani AFH, du Plessis NM, Steel HC, Pepper MS

https://doi.org/10.1017/gheg.2018.6

Deoxyribonucleic Acid Damage and Repair: Capitalizing on Our Understanding of the Mechanisms of Maintaining Genomic Integrity for Therapeutic Purposes

Helena JM, Joubert AM , Grobbelaar S, Nolte EM, Nel M, Pepper MS, Coetzee M, Mercier AE

https://doi.org/10.3390/ijms19041148

Sperm macrocephaly syndrome in the ostrich Struthio camelus: morphological characteristics and implications for motility

du Plessis L, Bonato M, Durandt C, Cloete SWP, Soley JT

https://doi.org/10.1071/RD18242

Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape

Dessels, C, Alessandrini M, Pepper MS

http://dx.doi.org/10.1002/sctm.17-0244

Clofazimine, but Not Isoniazid or Rifampicin, Augments Platelet Activation in vitro

Anderson R, Theron AJ, Nel JG, Durandt C, Cholo MC, Feldman C, Tintinger GR

https://doi.org/10.3389/fphar.2018.01335

Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations

Ambele MA, Pepper MS, van Heerden MB, van Heerden WFP

https://doi.org/10.1002/hed.25566

Comparison of human platelet lysate alternatives using expired and freshly isolated platelet concentrates for adipose-derived stromal cell expansion

Dessels C, Durandt C, Pepper MS

https://doi.org/10.1080/09537104.2018.1445840

An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles

Stander BA, van Vollenstee FA, Kallmeyer

K, Potgieter M, Joubert A, Swanepoel A, Kotze L, Moolman S, Pepper MS

https://doi.org/10.1371/journal.pone.0198248

Cystic fibrosis in South Africa: A changing diagnostic paradigm

van Rensburg J, Alessandrini M, Stewart C, Pepper MS

https://doi.org/10.7196/SAMJ.2018.v108i8.13225

2017

Cancer Stem Cells in Head and Neck Carcinomas: Identification and Possible Therapeutic Implications

Wolmarans E, Boy SC, Nel S, Mercier AE, Pepper MS

https://doi.org/10.1007/5584_2017_116

Cystic Fibrosis in the African Diaspora

Stewart C, Pepper MS

https://doi.org/10.1513/AnnalsATS.201606-481FR

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

Senthebane DA, Rowe A, Thomford NE, Shipanga H, Munro D, Mazeedi MAMA, Almazyadi HAM, Kallmeyer K, Dandara C, Pepper MS, Parker MI, Dzobo K

https://doi.org/10.3390/ijms18071586

Exporting DNA – striking a balance between preventing exploitation and promoting innovation

Pepper MS

https://doi.org/10.7196/SAMJ.2017.v107i2.12122

Dermatologie et infections sexuellement transmissibles

Saurat et al

ISBN : 9782294746499

Contrasting Views on the Role of Mesenchymal Stromal/Stem Cells in Tumour Growth: A Systematic Review of Experimental Design

Oloyo AK, Ambele MA, Pepper MS

https://doi.org/10.1007/5584_2017_118

Abstract B36: Contrasting views on the role of mesenchymal stem cells in tumor progression: A systematic review

Oloyo AK, Ambele MA, Pepper MS

https://doi.org/10.1158/1538-7445.NEWFRONT17-B36

Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro

Nel JG, Durandt C, Theron AJ, Tintinger GR, Pool R, Richards GA, Mitchell TJ, Feldman C, Anderson R

https://doi.org/10.1016/j.jinf.2017.02.010

Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis

Naidoo A, Ramsuran V, Chirehwa M, Denti P, McIlleron H, Naidoo K, Yende-Zuma N, Singh R, Ngcapu S, Chaudhry M, Pepper MS, Padayatchi N

https://doi.org/10.2217/pgs-2017-0144

Ownership and human tissue – the legal conundrum: A response to Jordaan’s critique

Mahomed S, Slabbert MN, Pepper MS

https://doi.org/10.7196/SAMJ.2017.v107i3.12062

Chapter 4: Manipulating the Tumor Microenvironment: Opportunities for Therapeutic Targeting

Mabeta P, Pepper MS

https://doi.org/10.2174/97816810838961170801

Application of the AMLprofiler Diagnostic Microarray in the South African Setting

Kappala SS, Alessandrini M, Matlhako T, Beltchev E, Pool R, Pepper MS

https://doi.org/10.1155/2017/2560191

Abstract: 12.30 In Vivo Tracking Of Adipose-Derived Mesenchymal Stromal Cells During Physiological Wound Repair

Kallmeyer K, Pepper MS, Pittet-CuÉNod B, Modarressi A

https://doi.org/10.1097/01.GOX.0000512417.20113.77

Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion

Jackson CS, Durandt C, Janse van Rensburg I, Praloran V, Brunet de la Grange P, Pepper MS

http://dx.doi.org/10.1016/j.scr.2017.04.007

Reactive Oxygen Species and NOX Enzymes are Emerging as Key Players in Cutaneous Wound Repair

André-Lévigne D, Modarressi A, Pepper MS, Pittet-Cuénod B

https://doi.org/10.3390/ijms18102149

The Role of Reactive Oxygen Species in Adipogenic Differentiation. In: Van Pham P. (eds) Stem Cells: Biology and Engineering.

de Villiers D, Potgieter M, Ambele MA, Adam L, Durandt C, Pepper MS

https://doi.org/10.1007/5584_2017_119

Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans

Choudhury A, Ramsay M, Hazelhurst S, Aron S, Bardien S, Botha G, Chimusa ER, Christoffels A, Gamieldien J, Sefid-Dashti MJ, Joubert F, Meintjes A, Mulder N, Ramesar R, Rees J, Scholtz K, Sengupta D, Soodyall H, Venter P, Warnich L, Pepper MS.

https://doi.org/10.1038/s41467-017-00663-9

Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study

Chaudhry M, Alessandrini M, Rademan J, Dodgen TM, Steffens FE, van Zyl DG, Gaedigk A, Pepper MS.

https://doi.org/10.2217/pgs-2016-0185

The state of gene therapy research in Africa, its significance and implications for the future

Arbuthnot P, Maepa MB, Ely A, PepperMS

https://doi.org/10.1038/gt.2017.57

Identification of transcription factors potentially involved in human adipogenesis in vitro

Ambele MA, Pepper MS

https://doi.org/10.1002/mgg3.269

AMLprofiler: A Diagnostic and Prognostic Microarray for Acute Myeloid Leukemia in Methods for Molecular Biology

Alessandrini M, Kappala SS, Pepper MS.

https://doi.org/10.1007/978-1-4939-7142-8_7

2016

Chapter 1- Stem Cell Therapy: Accepted Therapies, Managing the Hope of Society, and a Legal Perspective

Botes WM, Slabbert MN, Alessandrini M, Pepper MS

https://doi.org/10.1007/978-3-319-40073-0

Chapter 7- Isolation and Characterization of Adipose- Derived Stromal Cells

van Vollenstee FA, Dessels C, Kallmeyer K, de Villiers D, Potgieter M, Durandt C, Pepper MS

https://doi.org/10.1007/978-3-319-40073-0_7V

Chapter 8- Cord Blood Stem Cell Banking

Steel HC, Alessandrini M, Mellet J, Dessels C, Oloyo AK, Pepper MS

https://doi.org/10.1007/978-3-319-40073-0

Chapter 10- Harvesting and Collection of Adipose Tissue for the Isolation of Adipose-Derived Stromal/Stem Cells

van Vollenstee FA, Hoffmann D, Pepper MS

https://doi.org/10.1007/978-3-319-40073-0_10

Human adipose derived mesenchymal stromal cells transduced with GFP lentiviral vectors: assessment of immunophenotype and differentiation capacity in vitro

van Vollenstee FA, Jackson C, Hoffmann D, Potgieter M, Durandt C, Pepper MS

https://doi.org/10.1007/s10616-016-9945-6

Challenges raised by gene editing

Pepper MS

https://issues.org/challenges-raised-by-gene-editing/#.Yfus5tb7DxE.link

Cystic fibrosis on the African continent

Stewart C, Pepper MS

https://doi.org/10.1038/gim.2015.157

Cystic Fibrosis in Africa: not a Caucasian-only disease (Genepod talk)

Stewart C, Pepper MS

Genepod Talk

Mitochondrial transfer: Implications for assisted reproductive technologies

Reznichenko AS, Huyser C, Pepper MS

https://doi.org/10.1016/j.atg.2016.10.001

CRISPR-Cas: Revolutionising genome engineering 

Nicholson SA, Pepper MS

http://dx.doi.org/10.7196/samj.2016.v106i9.11061

Pneumolysin Mediates Platelet Activation In Vitro

Nel JG , Durandt C , Mitchell TJ , Feldman C , Anderson R , Tintinger GR

https://doi.org/10.1111/cei.12766

Neutrophil extracellular traps and their role in health and disease

Nel JG, Theron AJ, Pool R, Durandt C, Tintinger GR, Anderson R.

https://doi.org/10.17159/sajs.2016/20150072

HLA typing: Conventional techniques v. next-generation sequencing

Mellet J, Gray CM, Pepper MS

https://doi.org/10.7196/SAMJ.2016.v106i1.8570

Could we offer mitochondrial donation or similar assisted reproductive technology to South African patients with mitochondrial DNA disease?

Meldau S, Riordan G, van der Westhuizen F, Elson JL, Smuts I, Pepper MS, Soodyall H

https://doi.org/10.7196/SAMJ.2016.v106i3.10170

Social justice and research using human biological material: A right

to respond

Mahomed S, Slabbert MN, Pepper MS

https://doi.org/10.7196/SAMJ.2016.v106i9.11379

Implications of direct-to-consumer whole-exome sequencing in South Africa

Lombard Z, Baine F, Krause A, Lochan A, Macualay S, Spencer C, Aldous C, de Vries J, Fieggen K, Henderson B, Hoal E, Kinnear C, Kinsley N, September A, Urban M, Soodyall H, Pepper M, Ramsay M

https://doi.org/10.7196/SAMJ.2016.v106i2.10534

The FitTrack Index as fitness indicator: A pilot study

Janse van Rensburg DC, Grant CC, Jansen van Rensburg A, Botha RPG, Wood PS, Nolte K, Fletcher L, du Toit PJ, Pepper MS, Kruger PE

https://doi.org/10.4102/hsag.v21i0.1004

Fibroblast-Derived Extracellular Matrix Induces Chondrogenic Differentiation in Human Adipose-Derived Mesenchymal Stromal/Stem Cells in Vitro

Dzobo K, Turnley T, Wishart A, Rowe A, Kallmeyer K, van Vollenstee FA, Thomford NE, Dandara C, Chopera D, Pepper MS, Parker MI

https://doi.org/10.3390/ijms17081259.

Wharton’s Jelly-Derived Mesenchymal Stromal Cells and Fibroblast-Derived Extracellular Matrix Synergistically Activate Apoptosis in a p21-Dependent Mechanism in WHCO1 and MDA MB 231 Cancer Cells In Vitro

Dzobo K, Vogelsang M, Thomford NE, Dandara C, Kallmeyer K, Pepper MS, Parker MI

https://doi.org/10.1155/2016/4842134

Improved antiviral efficacy using TALEN-mediated homology directed recombination to introduce artificial primary miRNAs into DNA of hepatitis B virus

Dreyer T, Nicholson S, Ely A, Arbuthnot P, Bloom K

http://dx.doi.org/10.1016/j.bbrc.2016.08.152

Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort

Dodgen TM, Labuschagne C De J, van Schalkwyk A, Steffens FE, Gaedigk A, Cromarty AD, Alessandrini M, Pepper MS

https://doi.org/10.1038/tpj.2015.76

Making the Switch: Alternatives to Fetal Bovine Serum for Adipose-Derived Stromal Cell Expansion

Dessels C, Potgieter M, Pepper MS

https://doi.org/10.3389/fcell.2016.00115

Pharmacogenomics for infectious diseases in sub-Saharan Africa: Successes and opportunities

Chaudhry M, Alessandrini M, Pepper MS

https://doi.org/10.1016/j.atg.2016.04.001

Pharmacogenomics and Global Precision Medicine in the Context of Adverse Drug Reactions: Top 10 Opportunities and Challenges for the Next Decade

Alessandrini M, Chaudhry M, Dodgen TM, Pepper MS

https://doi.org/10.1089/omi.2016.0122

Novel flow cytometric approach for the detection of adipocyte subpopulations during adipogenesis

Durandt C, van Vollenstee FA, Dessels C, Kallmeyer K, de Villiers D, Murdoch C, Potgieter M, Pepper MS

https://doi.org/10.1194/jlr.D065664

Genome-wide analysis of gene expression during adipogenesis in human adipose-derived stromal cells reveals novel patterns of gene expression during adipocyte differentiation

Ambele MA, Dessels C, Durandt C, Pepper MS

https://doi.org/10.1016/j.scr.2016.04.011

2015

Homing properties of mesenchymal stromal cells

Karlien Kallmeyer & Michael S Pepper

https://doi.org/10.1517/14712598.2015.997204

Expression of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Childhood CF and Non-CF Bronchiectasis

R. Masekela, R. Anderson, K. de Boeck, M. Vreys, H.C. Steel, S. Olurunju, and R.J. Green

https://doi.org/10.1002/ppul.23121

Understanding the Implications of Mitochondrial DNA Variation in the Health of Black Southern African Populations: The 2014 Workshop

van der Westhuizen FH, Sinxadi PZ, Dandara C, Smuts I, Riordan G, Meldau S, Malik AN, Sweeney MG, Tsai Y, Towers GW, Louw R, Gorman GS, Payne BA, Soodyall H, Pepper MS, Elson JL

https://doi.org/10.1002/humu.22789

Human Leukocyte Antigen Diversity: A Southern African Perspective

Tshabalala M, Mellet J, Pepper MS

http://dx.doi.org/10.1155/2015/746151

Biocompatibility and biodegradation of protein microparticle and film scaffolds made from kafirin (sorghum prolamin protein) subcutaneously implanted in rodent models

Taylor J, Anyango JO, Potgieter M, Kallmeyer K, Naidoo V, Pepper MS, Taylor JRN

https://doi.org/10.1002/jbm.a.35394

Cystic fibrosis on the African continent

Stewart C, Pepper MS

https://doi.org/10.1038/gim.2015.157

Stem cell tourism in South Africa: A legal update

Slabbert MN, Pepper MS, Mahomed S

https://doi.org/10.7196/SAJBL.8006

A global comparative overview of the legal regulation of stem cell research and therapy: Lessons for South Africa

Slabbert MN, Pepper MS

https://doi.org/10.7196/SAJBL.8004

Mitochondrial transfer: Ethical, legal and social implications in assisted reproduction

Reznichenko AS, Huyser c, Pepper MS

https://doi.org/10.7196/sajbl.8002

Gender and sexual diversity – changing paradigms in an ever-changing world

Pepper MS

https://doi.org/10.7196/SAMJnew.8169

Legislation governing pluripotent stem cells in South Africa

Pepper MS, Gouveia C, Slabbert MN

https://doi.org/10.7196/SAJBL.8402

Human tissue legislation in South Africa: Focus on stem cell research and therapy

Pepper MS, Slabbert MN

https://doi.org/10.7196/SAJBL.8008

Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice

Myburgh R, Ivic S, Pepper MS, Gers-Huber G, Li D, Audigé A, Rochat M-A,

Jaquet V, Regenass S, Manz MG, Salmon P, Krause K-H, Speck RF.

 

https://doi.org/10.1128/JVI.00277-15

Constituting a public umbilical cord blood bank in South Africa

Mellet J, Alessandrini M, Steel HC, Pepper MS

https://doi.org/10.1038/bmt.2014.329

Altered expression of platelet factor 4 and basic fibroblast growth factor correlates with the inhibition of tumor growth in mice

Mabeta P, Pepper MS

http://dx.doi.org/10.1016/j.biopha.2014.11.018

Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study group

Logan M, Van der Merwe M-T, Dodgen TM,Myburgh R, EloffA, Alessandrini, Pepper MS

https://doi.org/10.1002/mgg3.180

Homing properties of mesenchymal stromal cells

Kallmeyer k, Pepper MS

https://doi.org/10.1517/14712598.2015.997204

Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort

Dodgen TM, Labuschagne CDJ, van Schalkwyk A, Steffens FE, Gaedigk A, Cromarty AD, Alessandrini M, Pepper MS

https://doi.org/10.1038/tpj.2015.76

Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort

Dodgen TM, Drögemöller BI, Wright GEB, Warnich L, Steffens FE, Cromarty AD, Alessandrini M, Pepper MS

https://doi.org/10.2217/pgs.15.80

Risperidone-associated adverse drug reactions and CYP2D6

polymorphisms in a South African cohort

Dodgen TM, Eloff A, Mataboge C, Roos LJL, van Staden WCW, Pepper MS

https://doi.org/10.1016/j.atg.2015.05.001

Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine

Čolić A, Alessandrini M, Pepper MS

http://dx.doi.org/10.3109/03602532.2014.982864

Progresses towards safe and efficient gene therapy vectors

Chira S, Jackson CS,Oprea I, Ozturk F, Pepper MS, Diaconu I, Braicu C, Raduly L-Z, Calin GA, Berindan-Neagoe I

https://doi.org/10.18632/oncotarget.5169.

Legal implications of translational promises of unproven stem cell therapy

Botes WM, Alessandrini M

https://doi.org/7196/SAJBL.8005

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

Atashi F, Modarressi A, Pepper MS

https://doi.org/10.1089/scd.2014.0484

2014

Priority pharmacogenetics for the African continent: focus on CYP450

Alessandrini M, Pepper MS

https://doi.org/10.2217/pgs.13.252

The Beta-2-Adrenoreceptor Agonists, Formoterol and Indacaterol, but Not Salbutamol, Effectively Suppress the Reactivity of Human Neutrophils In Vitro

Anderson R, Theron AJ, Steel HC, Durandt C, Tintinger GR, Feldman C

https://doi.org/10.1155/2014/105420

CHAPTER 23 The history and current status of forensic science in South Africa

Bernitz H, Kenyhercz MW, Kloppers B, L'Abbé EN, Labuschagne GN, Olckers A, Myburgh J, Saayman G, Steyn M, Stull KE

https://doi.org/10.1002/9781118724248.CH23

Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine

Colic A, Alessandrini M, Pepper MS

https://doi.org/10.3109/03602532.2014.982864

The correlation between the health-related fitness of healthy participants measured at home as opposed to fitness measured by sport scientists in a laboratory

Grant CC , Janse van Rensburg DC, Pepper MS, du Toit PJ, Wood PS, Ker J, Krüger PE, Grobbelaar CW, Nolte K, Fletcher F, Grant TC

https://doi.org/10.1080/20786190.2014.953888

Circulating Biomarkers of Immune Activation Distinguish Viral Suppression from Nonsuppression in HAART-Treated Patients with Advanced HIV-1 Subtype C Infection

Malherbe G, Steel HC, Cassol S, de Oliveira T, Seebregts CJ, Anderson R, Cassol E, Rossouw TM

https://doi.org/10.1155/2014/198413

Oxidative induction of pro-inflammatory cytokine formation by human monocyte-derived macrophages following exposure to manganese in vitro

Mokgobu MI, Cholo MC, Anderson R, Steel HC, Motheo MP, Hlatshwayo TN, Tintinger GR, Theron AJ

https://doi.org/10.3109/1547691X.2014.902877

Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction

Myburgh R, Cherpin O, Schlaepfer E, Rehrauer H, Speck RF, Krause KH, Salmon P

https://doi.org/10.1038/mtna.2014.58

Investigation of biofilm formation on a charged intravenous catheter relative to that on a similar but uncharged catheter

Richards GA, Brink AJ, McIntosh R, Steel HC, Cockeran R

https://doi.org/10.2147/MDER.S63449

Biocompatibility and biodegradation of protein microparticle and film scaffolds made from kafirin (sorghum prolamin protein) subcutaneously implanted in rodent models

Taylor J, Anyango JO, Potgieter M, Kallmeyer K, Naidoo V, Pepper MS, Taylor JR

https://doi.org/10.1002/jbm.a.35394

Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function

Theron AJ, Steel HC, Tintinger GR, Gravett CM, Anderson R, Feldman C

https://doi.org/10.1155/2014/608930

2013

University entrepreneurship in South Africa: Developments in technology transfer practices

Alessandrini M, Klose K, Pepper MS

https://doi.org/10.5172/impp.2013.15.2.205

Cytochrome P450 Pharmacogenetics in African populations

Alessandrini M, Asfaha S, Dodgen TM, Warnich L, Pepper MS

https://doi.org/10.3109/03602532.2013.783062

Adipocyte and adipogenesis

Ali AT, Hochfeld WE, Myburgh R, Pepper MS

https://doi.org/10.1016/j.ejcb.2013.06.001

Special Issue — Pharmacogenomics & personalized medicine, Journal of Applied and Translational Genomics

Barash CI, Pepper MS

https://doi.org/10.1016/j.atg.2013.10.004

C-C chemokine receptor type five (CCR5): An emerging target for the control of HIV infection

Barmania F, Pepper MS

https://doi.org/10.1016/j.atg.2013.05.004

Mutations in C-C chemokine receptor type 5 (CCR5) in South African individuals

Barmania F, Potgieter M, Pepper MS

https://doi.org/10.1016/j.ijid.2013.06.009

Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study

Dodgen TM, Hochfeld WE, Fickl H, Asfaha SM, Durandt C, Rheeder P, Drögemöller BI, Wright GE, Warnich L, Labuschagne CD, van Schalkwyk A, Gaedigk A, Pepper MS.

https://doi.org/10.1186/1471-2350-14-20

Opportunities and barriers to establishing a cell therapy programme in South Africa

Jackson CS, Pepper MS

https://doi.org/10.1186/scrt204

Establishing a Public Umbilical Cord Blood Stem Cell Bank for South Africa: An Enquiry into Public Acceptability

Meissner-Roloff M, Pepper MS

https://doi.org/10.1007/s12015-013-9463-2

Curbing stem cell tourism in South Africa

Meissner-Roloff M, Pepper MS

https://doi.org/10.1016/j.atg.2013.05.001

Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation

Potgieter M, Pretorius E, Pepper MS

https://doi.org/10.1111/nure.12011

2012

Pilot Social Feasibility Study for the Establishment of a Public Human Umbilical Cord Blood Stem Cell Bank in South Africa

Meissner-Roloff M, Young W, Rangaka I, Lombaard H, Dhai A, Tsotsi N, Pepper MS

https://doi.org/10.1007/s12015-012-9390-7

 

- Author Fatima Barmania
Published by Fatima Barmania

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