Name: Theresa Rossouw

e-mail: [email protected]

Tel: 012-319-2626

Cell: 082 894 2224

 

Publications of the past 5 years:

Original publications in ISI accredited journals:

1. Feucht UD, Rossouw T, Van Dyk G, Forsyth B, Kruger M. Consequences of Prior Use of Full-dose Ritonavir as Single Protease Inhibitor as Part of Combination Antiretroviral Regimens on the Future Therapy Choices in HIV-1–Infected Children. Pediatr Infect Dis J. 2014;33(2):e53-9. doi: 10.1097/INF.0b013e31829f2694. [IF 3.57]
2. Rossouw T, Van Zyl C, Pope, A. Responsible conduct of research: global trends, local opportunities. S Afr J Sci. 2014;110(1/2):30-35. http://dx.doi.org/10.1590/sajs.2014/20130103. [IF 0.84]
3. Manasa J, Lessells R, Rossouw T, Naidu K, Van Vuuren C, Goedhals D, van Zyl G, Bester A, Skingsley A, Stott K, Danaviah S, Chetty T, Singh L, Moodley P, Iwuji C, McGrath N, Seebregts CJ, de Oliveira T. Southern African Treatment Resistance Network (SATuRN) regaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa. Database 2014 Feb 6;2014:bat082. doi: 10.1093/database/bat082. Print 2014. [IF 4.2]
4. Fernandez L, Rossouw T, Marcus T, Smit N, Kinkel F, Memon S. Hugo J. Factors Associated with Better Patient Understanding of their Management Plan in Tshwane Clinics. African Journal of Primary Health Care and Family Medicine. 2014;6(1). doi:10.4102/phcfm.v6i1.560 http://www.phcfm.org. [IF 0.18]
5. Tucker JD, Rennie S and the Social and Ethical Working Group on HIV Cure (David Bangsberg, Weiping Cai, Ben Cheng, Johanna Crane, Malcolm de Roubaix, Kevin Fenton, Gail Henderson, Arthur Kleinman, Lisa Hightow-Weidman, Ying-Ru Lo, Benjamin M. Meier, David Margolis, Keymanthri Moodley, Raul Necochea, Jingbao Nie, Malika Roman Isler, Stuart Rennie, Mark J. Siedner, Theresa Rossouw, Jeremy Sugarman and Joseph D. Tucker). Social and Ethical Implications of HIV Cure Research. AIDS. 2014 Jun 1;28(9):1247-50. doi: 10.1097/QAD.0000000000000210. [IF 6.407]
6. Moodley K, Sibanda NB, February K and Rossouw T. "It's my blood": ethical complexities in the use, storage and export of biological samples: perspectives from South African research participants. BMC Medical Ethics 2014;15:4. doi:10.1186/1472-6939-15-4). [IF 1.71]
7. Rossouw TM. Monitoring Early Warning Indicators for HIV drug resistance in South Africa: challenges and opportunities. Clin Infect Dis. 2014;58(11):1615-1617. Advance Access published March 21, 2014. doi: 10.1093/cid/ciu114). [IF 9.37]
8. Malherbe G, Steel H, Cassol S, de Oliveira T, Seebregts C, Anderson R, Cassol E, Rossouw T. Circulating biomarkers of immune activation distinguishes viral suppression from non-suppression in HAART-treated patients with advanced HIV-1 subtype C. Mediators of Inflammation. 2014. Article ID 198413, 7 pages, 2014. doi:10.1155/2014/198413. [IF 3.88] (Recognized by the MRC as one of the top articles for the second quarter of 2014). 
9. Lessells R, Stott KE, Manasa J, Naidu KK, Skingsley A, Rossouw T and de Oliveira T. Implementing antiretroviral resistance testing in a primary health care HIV treatment programme in rural KwaZulu-Natal, South Africa: early experiences, achievements and challenges. BMC Health Services Research. 2014;14:116 doi:10.1186/1472-6963-14-116. [IF 1.77]
10. Okonta P, Rossouw T. Misconduct in research: a descriptive survey of attitudes, perceptions and associated factors in a developing country. BMC Medical Ethics. 2014;15:25. doi:10.1186/1472-6939-15-25. [IF 1.71]
11. Nieuwoudt M, Lameris R, Corcoran C, Rossouw TM, Slavik T, du Plessis J, Omoshoro-Jones JAO, Stivaktas PI, Potgieter F, van der Merwe SW. Polymerase chain reaction amplifying mycobacterial DNA from aspirates obtained by endoscopic ultrasound allows accurate diagnosis of mycobacterial disease in HIV-positive patients with abdominal lymphadenopathy. Ultrasound Med Biol. 2014;40(9):2031-8. doi: 10.1016/j.ultrasmedbio.2014.04.006. Epub 2014 Jul 9. [IF 2.445]
12. Rossouw TM, van Rooyen M, Louw JM, Richter K. Blood-borne infections in health care workers in South Africa. South African Medical Journal 2014;104(11):732-735. DOI:10.7196/samj.8518. [IF 1.7]
13. Adewale T, Schoeman L, Rossouw TM. Knowledge and perceptions of research participants about clinical trials in Nigeria. Indian Journal of Medical Ethics 2015 Aug 25;-(-):1-3. [Epub ahead of print]
14. Rossouw TM, Crane J, Frenkel L. Ethics of HIV research in children. Lancet Infectious Diseases. 2015;6(5):634-5 [IF 22.433]
15. Rossouw TM, Feuct UD, Melikian G, van Dyk G, Thomas W, du Plessis N, Avenant T. Factors associated with the development of drug resistance mutations in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy in South Africa. PLoSONE 2015;10(7):e0133452. [IF 3.534]
16. Cassol E, Rossouw TM, Mahasha P, Malherbe G, Cassol S. CD14+ macrophages in the colon of AIDS patients express pro-inflammatory cytokines and are responsive to lipopolysaccharide (gutjnl-2013-306051). BMC Infectious Diseases 2015; 15(1):430. [IF 2.61]
17. Makhubele TG, Steel HC, Anderson R, van Dyk G, Theron AJ, Rossouw TM. Effect of antiretroviral therapy and maternal smoking on systemic immune activation profiles in children infected with HIV-1 Subtype C. Mediators of Inflammation 2016: article ID 9026573, http://dx.doi.org/10.1155/2016/9026573. [IF 3.236]

 

18. Rossouw TM, Nieuwoudt M, Manasa J, Malherbe G, Lessells RJ, Pillay S, Danaviah S, Mahasha P, van Dyk G, de Oliveira T. HIV Drug Resistance Levels in Adults Failing First Line Antiretroviral Therapy in Urban and Rural Settings in South Africa. HIV Medicine 2016; 18(2):104-114 doi: 10.1111/hiv.12400. [Epub ahead of print] [IF 3.988]
19. Crane J and Rossouw TM. Inequality and Ethics in Pediatric HIV Remission Research: From Mississippi to South Africa and Back. Global Public Health Glob Public Health. 2017 Feb; 12(2): 220–235. [IF 0.92]
20. Rossouw TM, Hitchcock S, Botes M. The end of the line? A case of drug resistance to third-line antiretroviral therapy. Southern African Journal of HIV Medicine 2016;17(1):454 doi: 10.4102/hivmed.v17i1.454 [IF 0.90]
21. Moodley K, Rossouw T, Staunton C, Colvin CJ.  Synergies, tensions and challenges in HIV prevention, treatment and cure research: exploratory conversations with HIV experts in South Africa. BMC Medical Ethics 2016;17:26 doi:  10.1186/s12910-016-0109-1 [IF 1.50].
22. Adewale T, Schoeman L, Rossouw T. Assessing participants' understanding and voluntariness of informed consent in a clinical trial in Nigeria. Journal of Clinical Research & Bioethics 2016;7:1000279. doi: 10.4172/2155-9627.1000279.
23. Rossouw TM, van Rooyen M, Richter K. Exposure incidents among medical students in Pretoria: gaps and opportunities. J Infect Dev Ctries 2017; 11(1):65-72. doi:10.3855/jidc.8940. [IF 1.30]
24. Kanthula R, Rossouw T, Feucht U, van Dyk G, Beck IA, Silverman R, Olson S, Salver C, Cassol S, Frenkel L. Prevalence and Persistence of HIV-drug-resistance among South African Children given Nevirapine Prophylaxis to Prevent Mother-to-Child-Transmission. AIDS 2017, 31:1143-8. DOI: 10.1097/QAD/0000000000001446. [IF 4.407]
25. Rossouw T, Tucker J, van Zyl G, Sikwesi K, Godfrey C. Barriers to HIV Remission Research in Resource Limited Settings. Journal of the International AIDS Society 2017, 20:2152. 

http://dx.doi.org/10.7448/IAS.20.1.21521  [IF 6.256]

26. Boswell M, Rossouw T. Approach to Tenofovir-Associated Nephrotoxicity. Southern African Journal of HIV Medicine, in press. [IF 0.68]

 

 

Review articles in ISI accredited journals:

1. Rossouw TM, Anderson R, Feldman C. Impact of HIV infection and smoking on lung immunity and related disorders. European Respiratory Journal 2015, 46 (5) 1461-1470; DOI: 10.1183/13993003.00649-2015. [IF 7.636]

 

2. Feldman C, Anderson A, Rossouw T. HIV-related Pneumococcal Disease Prevention in Adults. Expert Rev Respir Med. 2017:11(3):181-199. doi:10.1080/17476348.2017.1289841.

 

3. Sokoya T, Steel HC, Nieuwoudt M, Rossouw TM. HIV as a cause of Immune Activation and Immunosenescence: A Review. Mediators of Inflammation: Cellular Senescence and Inflammaging in Age-Related Diseases, 2017: 6825493. doi: 10.1155/2017/6825493  [IF 3.232]
4. Theron AJ, Anderson R, Rossouw TM, Steel HC. The role of TGF-b1 in HIV infection. Frontiers in Immunology. In press. [IF 6.429]

 

 

Book chapters:

1. Rossouw T & Moodley K. 2017. HIV and Ethics, in Medical Ethics, Law and Human Rights: A South African Perspective. Edited by K Moodley. Van Schaik: South Africa.

 

Publications in non-ISI accredited journals:

1. Rossouw, TM. Antiretroviral options in the presence of HIV drug resistance. Medical Chronicle 2015; 42-44.

 

Conference proceedings:

Oral presentations:

1.  “ART: The new, the old and the ugly”. Southern African HIV Clinicians Society Pretoria branch meeting August 2015, Pretoria.
2. “Immune activation in HIV: causes and consequences”. 54th International Congress of the Federation of South African Societies of Pathology, September 2015.
3. “Ethical & Practical Implications of Implementing START Data in South Africa”. South African Medical Association HIV Update, Pretoria, September 2015.
4. “Blood-borne Infections Among Healthcare Workers in South Africa”. Safety Summit Conference, Johannesburg, August 2015 & Pathology Conference, Pretoria, October 2015.
5. “HIV Overview”. Guest lecture for Carleton University Masters students, October 2015.
6. “HIV life cycle revisited: What’s new in basic science?” Plenary address at Southern African HIV Clinicians Society 3^rd Biennial Conference, Johannesburg, April 2016.
7. “Biomedical and Public Health Approaches to HIV”. Irish Aid Workers Workshop, Pretoria, April 2016.
8. “Ethical and social implications of proposed HIV cure research: stakeholder perspectives from South Africa.” Presented by co-investigator, Prof K Moodley. International AIDS Society Conference, Durban 2016.
9. “Women in Science: Tackling gender stereotypes”. Invited lecture at University of Pretoria Faculty Day, 24 August 2016.
10. “Investigating the relationship between cigarette smoking; markers of immune activation and HIV‐1 treatment failure in adult patients”. University of Pretoria Faculty Day, 23 August 2017.

 

11. “Growth, neurodevelopmental delay & immune function in HIV-exposed uninfected children”. Physiology Society of South Africa Conference, 29 August 2017.

 

12. “An update on using ART in HIV-infected pregnant women.” MSD Summit, 13-14 October 2017.

 

Poster presentations:

1. Makhubele TG, Theron AJ, Anderson R, Rossouw TM. Immune activation profiles in HIV-infected females do not correlate with smoking status. University of Pretoria Faculty Day 2014.
2. Van Dyk G, Hitchcock SH, Muller EK, Venter L, Rossouw TM. Low level of major protease-inhibitor mutations detected in HIV-infected patients following lopinavir-based antiretroviral therapy suggests non-adherence. University of Pretoria Academic Year Day 2014.
3. Van Dyk G, Danaviah S, Feucht U, Thomas W, Avenant T, du Plessis N and Rossouw T. Phylogenetic Analysis Distinguishes Between Transmitted and Acquired HIV-1 Drug Resistance After Failed Prevention of Mother-To-Child Transmission. University of Pretoria Academic Year Day 2014 and Southern African HIV Clinician Society Conference, Cape Town, September 2014. 
4. Kanthula R, van Dyk G, Cassol S, Frenkel L, Rossouw T. Persistence of HIV Drug Resistance in Children Exposed to Nevirapine Prophylaxis. Accepted as a poster presentation at the 2016 Conference on Retroviruses and Opportunistic Infections (CROI), Boston, USA.
5. Feucht U, Melikian G, Van Dyk G, du Plessis N, Avenant T, Frenkel L, Rossouw T. Baseline drug resistance and viral suppression on antiretroviral therapy in HIV-infected children who failed prevention of mother to child transmission programmes. Peadiatric HIV Satellite Meeting to IAS, Durban, 2016.
6. Mahasha P, Cassol E, Danaviah S, Bond R, Seebregts C, van der Merwe S, Rossouw T and de Oliveira T. Differential Distribution and Evolution of HIV-1 RNA Variants in the Gastrointestinal Tract of Antiretroviral Naïve African AIDS Patients with Diarrhea and (or) Weight Loss. Retroviruses Conference, Cape Town, 2016.
7. George G, Pepper M, van Dyk G, Pool R, Rossouw T, Durandt C. Haematological Manifestations in HIV-1 Infected, Treatment Naive Participants From Eersterust Community Health Clinic. University of Pretoria Faculty Day, August 2016.
8. Clemson N, Durandt C, Rossouw TM, du Toit P. Testing the association between macrophage polarization and head circumference in HIV exposed and unexposed children born at Kalafong hospital. University of Pretoria Faculty Day, 22-23 August 2017 & Physiology Society of South Africa Conference, 29 August 2017.

 

Policy documents etc.: N/A

Media articles/interviews/etc.:

1. Television appearance (eNCA) 2014: Interview: HIV and sex workers.
2. HIV Cure video in collaboration with the University of Stellenbosch.

 

Other:

NRF rated members of the group:

None

Awards/distinctions of the past 5 years:

1. Invited plenary address at the Southern African HIV Clinician Society Conference held in Johannesburg, 2016.

 

2. Nominated for 2015/2016 National Science and Technology Forum award for Communication for outreach and creating awareness (for an outstanding contribution to Science and Technology and innovation by a team or individual)

 

3. Second runner-up publication in the Clinical Sciences at the Faculty of Health Sciences of the University of Pretoria in 2014.

 

4. Mediators of Inflammation article has been recognized by the South African Medical Research Council as one of the top articles for the second quarter of 2014.

 

5. Invited editorial for the Clinical Infectious Diseases journal on implementing Early Warning Indicators for HIV-associated drug resistance in South Africa.

 

 

updated 22/05/2019