Name:  Dr Chantal van Niekerk

e-mail:  [email protected]

Tel:  012-319-2550

Cell:  083 379 1457

 

Publications of the past 5 years:

Original publications in ISI accredited journals:

1. Van Deventer BS, Du Toit-Prinsloo L, Van Niekerk C.  2018.  Feasibility of analysis of the SCN5A gene in paraffin embedded samples in sudden infant death cases at the Pretoria Medico-Legal Laboratory, South Africa.  Forensic Science, Medicine and Pathology doi: 10.1007/s12024-018-9995-5. [Epub ahead of print]

 

2. Chale-Matsau B, Van Niekerk C, Pillay TS. 2018.  Discordant calcium and parathyroid hormone with presumed epileptic seizures.  Clincal Chemistry 64(3): 442-446

 

3. Van Deventer BS, Du Toit-Prinsloo L, Van Niekerk C.  2017.  Long QT syndrome and sudden unexpected deaths in infants.  Journal of Clinical Pathology (JCP Online First, published on June 29, 2017 as 10.1136/jclinpath-2016-204199)
4. Prinsloo A, Pool R, Van Niekerk C.  2017.  Preliminary data on micro-RNA expression profiles in a group of South African patients diagnosed with chronic myeloid leukaemia.  Molecular and Clinical Oncology 7:386-390 
5. Chale-Matsau B, Van Niekerk C, Pillay TS. 2017.  Discordant calcium and parathyroid hormone with presumed epileptic seizures.  Clincal Chemistry (accepted)
6. Chirambo GM, Van Niekerk C, Crowther NJ.  2017.  The role of alkaline phosphatase in intracellular lipid accumulation in the human hepatocarcinoma cell line, HepG2.  Experimental and Molecular Pathology  102(2):  224-229
7. Chirambo GM, Van Niekerk C, Crowther NJ.  2017.  Specific knock-down of tissue non-specific alkaline phosphatase mRNA levels inhibits intra-cellular lipid accumulation in 3T3-L1 and HepG2 cells.  International Journal of Experimental Pathology (accepted)

 

Published conference proceedings:

• Van Deventer BS, Du Toit-Prinsloo L & Van Niekerk C.  2017.  Post mortem genetic testing of LQTS in sudden infant death cases: Pretoria Medico-Legal Laboratory.  21^st Triennial meeting of the International Association of Forensic Science.  Published in Forensic Science International 277 (supplement 1)

 

Presentations:

 

ASFM conference, 2017 (Bloemfontein)

• B van Deventer, L Du Toit-Prinsloo, C van Niekerk. Post mortem genetic testing of long QT syndrome in sudden infant death cases at the Pretoria Medico-Legal Laboratory.

 

SEMDSA conference, 2016 (Cape Town)

• B Chale-Matsau, C van Niekerk, T Pillay. Pseudohypoparathyroidism with presumed epileptic seizures.

 

Faculty Day, 2016

• B van Deventer, L Du Toit-Prinsloo, C van Niekerk. Post mortem genetic testing of long QT syndrome in sudden infant death cases at the Pretoria Medico-Legal Laboratory.

 

Genomics Research Institute Symposium, 2015 (Pretoria)

• B van Deventer, L Du Toit-Prinsloo, C van Niekerk. Developing a successful method for DNA extraction from archival formalin-fixed, paraffin-embedded myocardial tissue blocks for post mortem genetic analysis of the SCN5A gene in SIDS babies.

 

 UP Faculty Day 2015 – 2 oral presentations

• B van Deventer, L Du Toit-Prinsloo & C van Niekerk. Developing A Successful Method For Dna Extraction From Archival Formalin‐Fixed, Paraffin‐Embedded Myocardial Tissue Blocks For Post Mortem Genetic Analysis Of The Scn5a Gene In Sids Babies. 

 

• N Matthee, H Lombaard & C van Niekerk. Quantifying And Analysing Fetal Dna Extracted From Maternal Plasma To Establish Fetal Sex And Rhesus D Blood Grouping For Routine Testing

 

UniPath conference in Pretoria - 2014

• E Pretorius, NM Oosthuizen & C van Niekerk . Gene analysis of FGF23 and PHEX genes in South African patients diagnosed with hypophosphataemic rickets. 

 

• J. Lombard, NM Oosthuizen & C van Niekerk. The obstacles with using high resolution melt real-time PCR to genotype 21-hydroxylase deficiency. 

 

• P Yu, NM Oosthuizen & C van Niekerk. Usability of DNA obtained from formalin-fixed paraffin-embedded tissue in conventional PCR analysis.

 

Policy documents etc.:

Revision to the current legislature with regards to DNA analysis for post mortem application - discussions with various affected parties are underway.

 

update 22/05/2019