DR N OCTOBER |
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Tel +27 (0)12 420-4905Email [email protected]Office NS1 Room 4-46Position Senior Lecturer (Organic Chemistry)Academic qualification PhD |
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TeachingOrganic Chemistry (undergraduate and postgraduate) Modules: CMY 127, CMY 154, CHM 181, CHM 215, CMY 384, CMY 708 (HONS), CMY 709 (HONS) |
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Practical training: All Organic Chemistry modules (1st-3rd years) and Honours projects Modules: CMY 127, CMY 154, CHM 181, CHM 215, CMY 384, CMY 719 |
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Research interestsMedicinal Chemistry, Synthetic Chemistry and Natural products |
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Selected publicationsC. W. L. Fidèle, M. Balemaken Missi, October, N.; , P.H. B. Didoue, N. H .N., Ikome, J-P., Abdou, et. al., Antibacterial and Antioxidant Activities of the Extract and Some Flavonoids From Aerial Parts of Echinops Gracilis O. Hoffm. (Asteraceae), Natural Product Communications, 16(3): 1–6, 2021. Ajayi, O.S., Balogun, O.S., Olawuni, I.J, October, N., Adigun, R., Akinlade, I.G.; Bicyclic Diterpenoid Lactones, Alpha Amylase Inhibition and Antioxidant Activities from Andrographis paniculata Nees; Tropical Journal of Natural Product Research.; Vol 5 issue 2, 2021. Adigun, R. A.; Malan, F.; Balogun, M. O.; October, N.; Substitutional effects on the thermal stability and reactivity of dihydropyrimidinones ; Journal of Molecular Structure; 1223, 129193, 2021. Adigun, R. A.; Malan, F.; Balogun, M. O.; October, N.; Tetrahydropyrimidinones/thiones stabilized by trifluoromethyl-containing β-diketones; Journal of Molecular Structure; 1202, 127281, 2020. Ajani, O. O.; Joseph, O. E.; Iyaye,K. T.; October, N.; Aderohunmu, D.V.; Olorunshola, S. J.; Audu, O. Y.; Facile Synthesis, Characterization and in vitro Antibacterial Efficacy of Functionalized 2-Substitued Benzimidazole Motifs; Indones. J. Chem., 20(1), 72-87, 2020. Thakur, A.; Chun, Y.S.; October, N.; Yang, H.O.; Maharaj, V.; Potential of South African medicinal plants targeting the reduction of Aβ42 protein as a treatment of Alzheimer's disease, J Ethnopharmacol.;231:363-37, 2019. Ajani, O. O.; Akande, M. M.; October, N.; Siyanbola, T. O.; Aderohunmu, D. V.; Akinsiku, A. A.; Olorunshola, S. J.; Microwave assisted synthesis, characterization and investigation of antibacterial activity of 3-(5-(substituted-phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-2Hchromen-2-one derivatives, Arab Journal of Basic and Applied Sciences, Vol. 26, No. 1, 362–375, 2019. Mshelia, H. E.; Ugwah-Oguejiofor, C-J.; October, N.; Abubakar, K.; Isolation of Oleanolic Acid from Parinari curatellifolia (Planch Ex. Benth) Stem Bark and Evaluation of its Anticonvulsant and Sedative activities in Rodents; Trop J Nat Prod Res; 3(1); 17-21; 2019. Anas, A.; Ahmed, A.; Umar, S.; Jajere, U.M.; Mshelia, E.H. ; October, N.; Inhibitory effect of isolated lupeol from stem bark of Diospyros mespiliformis Horsch (Ebenaceae) against some microbial pathogens; Bayero Journal of Pure and Applied Sciences, 10(1): 293 – 299, 2017. Conference proceedings:NationalIsolation and Identification of cytotoxic compounds from a Tephrosia species, Adetola Adewole, Natasha October (Supervisor) , Mamoalosi Selepe (Co-supervisor), Oral Presentation at Franck Warren Organic Chemistry Conference, 7-11 July 2019. Organic and nanoparticle derived composites and their potential application as antimicrobials and antifungals, Mpheleki Lupiwana (Presenter), Natasha October (Supervisor), Mohammed Balogun (Co-supervisor), Poster Presentation at Franck Warren Organic Chemistry Conference, 7-11 July 2019. In- Silico design, Chemical Synthesis and Biological Screening of Novel 4-(1H)-pyridone based antimalarial agents, Oluwatosin Yemisi Audu, (Presenter), Natasha October(Supervisor), Ajani Olayinka (Co-supervisor), Oral Presentation at Franck Warren Organic Chemistry Conference, 7-11 July 2019. Syntheses and biological evaluation of novel 4(1H)-pyridone derivatives targeting cytochrome Bc1 Qi site of Plasmodium Falciparum based on in- silico studies, Oluwatosin Audu , Andre Stander , Olayinka Ajani and Natasha October (Supervisor), MOMR Malaria conference, November 2017. InternationalOrganic and nanoparticle derived composites and their potential application as antimicrobials and antifungals, Mpheleki Lupiwana (Presenter), Natasha October (Supervisor), Mohammed Balogun (Co-supervisor), Poster Presentation, International Conference On Phosphorus, Boron and Silicon, 2-4 December 2019. Syntheses and Biological Evaluation of novel 4(1H)-Pyridone derivatives targeting cytochrome bc1 Qi site of Plasmodium Falciparum based on in silico studies, Poster Presentation, Oluwatosin Yemisi Audu, (Presenter), Natasha October (Supervisor), Ajani Olayinka (Co-supervisor), MEEGID XIV – 14th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases, 6-9 November, 2018. |
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CollaborationsNationalPhysiology Department, University of Pretoria (Dr A Standers) Department of Biochemistry, Genetics, and Microbiology, University of Pretoria (Dr Pontsho Moela) Chemistry Department, University of Pretoria, (Prof Vinesh Maharaj) Chemistry Department, University of Pretoria, (Dr Mamoalosi Selepe) Council for Scientific and Industrial Research (CSIR), (Dr Mohammed Balogun) InternationalDepartment of Chemistry, Covenant University (Prof. Olayinka O. Ajani) Department of Chemistry, Obafemi Awolowo University (Dr Kayode Ajayi) Department of Organic Chemistry, University of Yaoundé I (Prof D E Pegnyemb) Department of Pharmacology and Clinical Pharmacy, University of Western Cape (Dr Samuel A. Egieyeh) |
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Postgraduate students |
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Ethan Besaans |
MSc |
2016 |
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites |
Rasheed Adewale Adigun |
PhD |
2020 |
Synthesis and structure-activity relationships of resistance reversal dihydropyrimidinonebased antimalarials |
Anuradha Thakur |
PhD |
2020 |
Potential of South African medicinal plants as treatments for Alzheimer’s disease through Aβ42 protein reduction and identification of their active compounds |
Emmanuel Mshelia |
PhD |
2014 |
Evaluation of Parinari curatellifolia Planch Ex. Benth (Chrysobalanaceae) Extracts for Anticancer and Antioxidant Activities |
Marius Balemaken Missi |
PhD |
2017-present |
Bioactive Phenolic Compounds as Antimicrobial, Antioxidant and Anticancer agents |
AUDU Oluwatosin Yemisi |
PhD |
2017-present |
Design, synthesis, in silico and in vitro bio-evaluation of potential agents against malaria, cancer and microbial infections |
Adetola Henry Adewole |
PhD |
2018-present |
Scientific validation and authentication of the use and methods of treatment of traditional medicinal plant |
Tholithembelihle Nconco |
MSc |
2019-present |
Extraction, isolation and structural isolation of potential anticancer agents Agapanthus praecox ssp. Minimus |
Angela Bona |
MSc |
2020-present |
In vitro screening of plant-derived compounds with potential anticancer properties on breast- and cervical cancer cell lines |
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