We work at the interface between parasite biology and drug discovery and use the new biological insights we gain from studying different life cycle forms of the malaria parasite as a catalyst for drug discovery.
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We investigate gene regulatory mechanisms underlying the pathogenic processes that drive both asexual proliferation as well as gametocyte differentiation of malaria parasites. Continue reading… |
We focus on the discovery of compounds with transmission-blocking activity, i.e. compounds able to either kill gametocytes or gametes and thereby prevent transmission to mosquitoes. Continue reading… |
We translate our findings to the host-parasite interface to understand how transmission-blocking strategies can influence malaria epidemiology, particularly in pre-elimination settings in Africa. Continue reading… |
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