Immunopathology Research Group


The Immunopathology Research Group is a thriving hub of scientific exploration led by Prof. Theresa Rossouw, a professor in the Immunology Department at the University of Pretoria's Faculty of Health Sciences. Prof. Rossouw's international recognition as a researcher in the field of HIV is just one testament to the calibre of expertise driving our research endeavours.By establishing this group, a nurturing research infrastructure platform for researchers, postdoctoral fellows, as well as PhD and master’s students is provided. Within this dynamic environment, a fostering atmosphere where cutting-edge research flourishes and early-career clinician-scientists as well as scientists are mentored and supported is created.At the heart of our research lies a commitment to expanding our understanding of the immune system's intricate workings. We delve into the overactivation of the immune system, a pivotal factor in autoimmune diseases such as rheumatoid arthritis, as well as the intricacies of immune system dysfunction seen in primary immunodeficiency diseases. Moreover, we explore the challenges posed by acquired immunodeficiency diseases, with a particular focus on HIV.Through this group the opportunity to collaborate with leading national and international experts, engage in ground-breaking projects, and contribute to the deeper understanding of the complexities   of immunopathogenesis that transcend boundaries is created. Together, we embark on a journey to shed light on the mysteries of the activation and deactivation of the immune system, striving to improve the lives of individuals affected by immunological disorders. This quest to unravel the immunopathogenesis of specific diseases, we aim to contribute to shaping future healthcare, impact individuals, families, and communities, and make a lasting impact on the field of immunology.


In our Immunopathology Research Group located in Pretoria, South Africa, we envision a future where cutting-edge research leads to breakthroughs in understanding and combatting diseases at the intersection of immunology and pathology. Our mission is to advance medical knowledge, improve diagnostics, and contribute to development of innovative therapies that enhance the well-being of individuals, families, and communities.We are committed to fostering a collaborative and diverse research environment, bringing together scientists, clinicians, and experts from various disciplines. Through our dedication to excellence and innovation, we aim to unravel the complexities of immunopathological processes that underlie a wide range of diseases, from infectious diseases to autoimmune disorders and cancer.Our research unit will be at the forefront of exploring novel biomarkers, diagnostic tools, and therapeutic interventions, ultimately translating our findings into real-world applications. We aspire to contribute not only to the global scientific community but also to the local healthcare landscape, addressing health challenges specific to our region.Guided by our values of compassion, integrity, and service, we are committed to improving the health and well-being of all individuals, while remaining rooted in the principles of ethical medical research. Through dedication to our work and unwavering commitment to our vision, we will make a lasting impact on the field of immunopathology and, most importantly, on the lives of those we aim to serve.


The mission of our Immunopathology Research Unit, based in Pretoria, South Africa, is to advance scientific knowledge and innovation in the field of immunopathology. We are dedicated to conducting cutting-edge research that elucidates the complex interactions between the immune system and diseases, with the ultimate goal of improving human health.

Our core objectives are:

  1. Research Excellence: We strive for excellence in our research endeavours. Through rigorous scientific investigation, we aim to uncover the underlying mechanisms of diseases influenced by immunopathological factors. We are committed to conducting high-impact research that contributes to the global body of knowledge in immunopathology.
  2. Innovation and Translational Impact: We endeavour to be at the forefront of developing innovative diagnostics, therapies, and interventions. Our research is not confined to the laboratory; we actively work to translate our findings into practical applications that benefit patients and healthcare providers.
  3. Collaboration and Diversity: We foster a collaborative and inclusive research environment that brings together experts from diverse backgrounds, including scientists, clinicians, and healthcare professionals. By encouraging interdisciplinary collaboration, we aim to address complex health challenges from multiple angles.
  4. Local and Global Health: We recognize the importance of addressing both local and global health needs. Our research group is dedicated to contributing to solutions for healthcare challenges specific to Africa, while also making a meaningful contribution to global health through our research findings and innovations.
  5. Ethical Conduct: We conduct our research with the highest ethical standards. Integrity, transparency, and adherence to ethical principles are at the core of our research activities. We prioritize the well-being and safety of all individuals involved in our studies.
  6. Education and Outreach: We are committed to sharing our knowledge and expertise with the broader community. Through educational programs, outreach initiatives, and partnerships, we aim to raise awareness of immunopathological issues and promote scientific literacy.

In pursuit of our mission, we are dedicated to improving the understanding of immunopathogenesis, ultimately contributing to advancements in healthcare that benefit individuals, families, and communities. Our work is guided by a deep sense of responsibility to make a positive impact on the health and well-being of society



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