Anderson Students

Photo	Student	Project	Links
PhD
	Mandy Naude	In this study we will utilise publically available databases to assemble a panel of GPCRs that are differentially expressed between normal and tumourigenic breast tissue. The expression of these GPCRs will then be determined by reverse transcriptase polymerase chain reaction in both monolayer and three-dimensional cell culture systems. The effects of target genes on monolayer and three-dimensional cell culture systems will be functionally investigated.	https://www.linkedin.com/in/mandy-kim-naude-930927157/
MSc
	Robert Henkel	Growth hormone releasing hormone receptor (GHRHR) plays a central role in the HPS-axis and has been implicated in the growth and survival of various types of cancer. Despite this, the mechanisms regulating the expression of GHRHR in cancer are not clear. Recent papers have suggested that post-transcriptional regulation may play a significant role in this expression. Therefore, this study aims to examine the post-transcriptional regulatory mechanism(s) responsible for GHRHR dysregulation in prostate cancer cell lines.	-
	Zimazile Ndlovu	Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis can result in the development of precocious puberty, increasing the risk of developing various pathologies later in life. This study explores the role of Makorin RING Finger Protein 3 (MKRN3), a novel hypothalamic protein linked to central precocious puberty (CPP). We hypothesize that MKRN3 affects the stability of transcripts encoding proteins that regulate the activity of the HPG axis. This research will establish the molecular mechanisms governing the regulation of pubertal timing and could identify novel transcripts involved in HPG-axis activity, thus opening doors for future therapeutic intervention.	https://www.linkedin.com/in/zimazile-callista-ndlovu/

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