Publications

Title	Authors	DOI				Journal
2023
How nuclear envelope dynamics can direct laminopathy phenotypes	David van Heerden, Stefanie Klima, Iman van den Bout	https://doi.org/10.1016/j.ceb.2023.102290	Current Opinion in Cell Biology
Measuring oxytocin release in response to gavage: Computational modelling and assay validation	Hassan S, El Baradey H, Madi M, Shebl M, Leng G, Lozic M, Ludwig M, Menzies J, MacGregor D.	https://doi.org/10.1111/jne.13303	Journal of Neuroendocrinology
Comparative Evaluation of the Cytotoxicity of Doxorubicin in BT-20 Triple- Negative Breast Carcinoma Monolayer and Spheroid Cultures	Ncube KN, Jurgens T, Steenkamp V, Cromarty AD, van den Bout I, Cordier W.	https://doi.org/10.3390/biomedicines11051484	Biomedicines
Comparison of the effects of electronic cigarette vapours and tobacco smoke extracts on human neutrophils in vitro	Richards GA, Theron A J, van den Bout I, Anderson R, Feldman C, van Zyl Smit R, Chang J-W, Tintinger G R.	10.1183/23120541.00502-2022	European Respiratory Journal Open Research
In vitro evaluation of the tachykinin receptor-selectivity of DOTA- [Thi8,Met(O2)11]-Substance P	Suthiram J, Ebenhan T, Zeevaart JR, Sathekge MM, Pieters A, Anderson R, Mohamed- Moosa Z, Newton CL.	https://doi.org/10.3390/ijms24032134	International Journal of Molecular Sciences
2022
Transcriptome profiling of kisspeptin neurons from the mouse arcuatenucleus reveals new mechanisms in estrogenic control of fertility.	Göcz B, Rumpler É, Sárvári M, Skrapits K, Takács S, Farkas I, Csillag V, Trinh SH, Bardóczi Z, Ruska Y, Solymosi N, Póliska S, Szőke Z, Bartoloni L, Zouaghi Y, MessinaA, Pitteloud N, Anderson RC, Millar RP, Quinton R, Manchishi SM, Colledge H,Hrabovszky E.	https://doi.org/10.1073/pnas.2113749119			Proc Natl Acad Sci
The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide.	Robles JP, Zamora M, Siqueiros-Marquez L, Adan-Castro E, Ramirez-Hernandez G, Nuñez FF, Lopez-Casillas F, Millar RP, Bertsch T, Martínez de la Escalera G, Triebel J, Clapp C.	https://doi.org/10.1007/s10456-021-09800-x			Angiogenesis
Provocative tests with Kisspeptin-10 and GnRH set the scene for determining social status and environmental impacts on reproductive capacity in male African lions.	Ludwig M, Newton CL, Oosthuizen A, Homer NZM, Li XF, O’Byrne KT and Millar RP.	https://doi.org/10.1016/j.ygcen.2022.114127			General and Comparative Endocrinology
Social Media and COVID-19-Perceptions and Public Deceptions of Ivermectin, Colchicine and Hydroxychloroquine: Lessons for Future Pandemics.	Schellack N, Strydom M, Pepper MS, Herd CL, Hendricks CL, Bronkhorst E, Meyer JC, Padayachee N, Bangalee V, Truter I, Ellero AA, Myaka T, Naidoo E, Godman B.	https://doi.org/10.3390/antibiotics11040445			Antibiotics
Vasopressin acts as a synapse organizer in limbic regions by boosting PSD95 and GluA1 expression.	Zhang L, Padilla-Flores T, Hernández VS, Zetter MA, Campos-Lira E, Escobar LI, Millar RP, Eiden LE.	https://doi.org/10.1111/jne.13164			Journal of Neuroendocrinology
Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling and Migration.	Azubuike UF, Newton CL, van den Bout I.	https://doi.org/10.3390/ijms23158744			International Journal of Molecular Sciences
Cushing's syndrome update: 100 years after Minnie G.	Millar RP, Karavitaki N, Kastelan D	https://doi.org/10.1111/jne.13167			Journal of Neuroendocrinology
Oxytocin-a social peptide? Deconstructing the evidence.	Leng G, Leng RI, Ludwig M.	https://doi.org/10.1098/rstb.2021.0055			Philos Trans R Soc Lond B
2021
Functional rescue of inactivating mutations in the human neurokinin 3 receptor using pharmacological chaperones	Anderson RC, Hanyroup S, Song YB, Mohamed-Moosa Z, van den Bout JI, Schwulst AC, Kaiser U, Millar RP and Newton CL.	https://doi.org/10.3390/ijms23094587		International Journal of Molecular Sciences
Identification of peripheral oxytocin-expressing cells using systemically applied cell-type specific adeno-associated viral vector.	Paiva L, Lozic M, Allchorne A, Grinevich V, Ludwig M.	https://doi.org/10.1111/jne.12970		Journal of Neuroendocrinology
Seasonal expression and distribution of kisspeptin1 (kiss1) in the ovary and testis of freshwater catfish, Clarias batrachus: A putative role in steroidogenesis.	Singh A, Lal B, Parhar IS, Millar RP.	https://doi.org/10.1016/j.acthis.2021.151766		Acta Histochemica
Sex Disparities in COVID-19 Severity and Outcome: Are Men Weaker or Women Stronger?	Pivonello R, Auriemma RS, Pivonello C, Isidori AM, Corona G, Colao A, Millar RP.	https://doi.org/10.1159/000513346		Neuroendocrinology
A dual kisspeptin-GnRH immunogen for reproductive immunosterilization.	Junco JA, Fuentes F, Millar RP.	https://doi.org/10.1016/j.vaccine.2021.07.080		Vaccine
Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade..(2021)	Singh A, Lal B, Parkash J, Millar RP.	https://doi.org/10.1016/j.cbpb.2021.110642		Comp Biochem Physiol B Biochem Mol Biol.
Congenital Hypogonadotropic Hypogonadism with Anosmia and Gorlin Features Caused by a PTCH1 Mutation Reveals a New Candidate Gene for Kallmann Syndrome.	Barraud S, Delemer B, Poirsier-Violle C, Bouligand J, Mérol JC, Grange F, Higel- Chaufour B, Decoudier B, Zalzali M, Dwyer AA, Acierno JS, Pitteloud N, Millar RP, Young J.	https://doi.org/10.1159/000506640		Neuroendocrinology
Rescue of cell surface expression and signalling of mutant follicle-stimulating hormone receptors	Hanyroup S, Anderson RC, Nataraja S, Yu HN, Millar RP and Newton CL.	https://doi.org/10.1210/endocr/bqab134		Endocrinology
The multiple faces of the oxytocin and vasopressin systems in the brain.	Grinevich V, Ludwig M.	https://doi.org/10.1111/jne.13004		Journal of Neuroendocrinology
Continual proteomic divergence as a consequence of long-term spheroid culture.	Ellero A, van den Bout I, Vlok M, Cromarty D, and Hurrell T.	10.1038/s41598-021-89907-9		Scientific Reports
Rescue of mutant luteinizing hormone receptors with deficiencies in cell surface expression, binding and signalling	Newton CL, Anderson RC, Kreuchwig A, Krause G, Katz AA and Millar RP.	https://doi.org/10.1159/000508000		Neuroendocrinology
Onset of normal cycles in postpartum anovulatory dairy cattle treated with kisspeptin.	Burke CR, Roche JR, Millar RP, Clarke IJ.	https://doi.org/10.1530/RAF-21-		Reproduction and Fertility
The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application.	Anderson RA, Millar RP.	https://doi.org/10.1111/jne.13081		Journal of Neuroendocrinology
2020
Analogues of HPG hormone regulators for the management of pubertal disorders	Millar RP and Newton CL	https://doi.org/10.1016/j.coemr.2020.09.007			Current Opinion in Endocrine and Metabolic Research
Reciprocal antagonism between β1 and β3 integrins through kindlin-2 and Rho GTPases regulates cell cohesion and collective cell migration.	van der Bijl I, Nawaz K, Kazlauskaite U, van Stalborch A-M, Tol S, Jimenez Orgaz A, van den Bout I, Reinhard N R, Sonnenberg A, and Margadant C.	https://doi.org/10.1016/j.matbio.2020.05.005			Matrix Biology
Fasting affects amino acid nitrogen isotope values: a new tool for identifying nitrogen balance of free-ranging mammals.	Lübcker N, Whiteman JP, Newsome SD, Millar RP, de Bruyn PJN.	https://doi.org/10.1007/s00442-020-04645-5			Oecologia
What's in a whisker? High-throughput analysis of twenty-eight C19 and C21 steroids in mammalian whiskers by ultra-performance convergence chromatography-tandem mass spectrometry.	Lübcker N, Bloem LM, du Toit T, Swart P, de Bruyn PJN, Swart AC, Millar RP.	https://doi.org/10.1016/j.jchromb.2020.122028			Journal of Chromatography B
Recollections on Jean E. Rivier: A Giant in Neuroendocrinology.	Millar RP	https://doi.org/10.1159/000507085			Neuroendocrinology
Somato-dendritic secretion of neuropeptides.	Brown, CH., Ludwig, M., Stern, JE.	https://doi.org/10.1007/978-3-030-22989-4_4			-
Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation.	Brown CH, Ludwig M, Tasker JG, Stern JE.	https://doi.org/10.1111/jne.12856			Journal of Neuroendocrinology
2019
Social creatures: Model animal systems for studying the neuroendocrine mechanisms of social behaviour.	Robinson KJ, Bosch OJ, Levkowitz G, Busch KE, Jarman AP, Ludwig M.	https://doi.org/10.1111/jne.12807				Journal of Neuroendocrinology
Effects of optogenetic stimulation of vasopressinergic retinal afferents on suprachiasmatic neurones.	Hume C, Allchorne A, Grinevich V, Leng G, Ludwig M.	https://doi.org/10.1111/jne.12806				Journal of Neuroendocrinology
Coding of odors in the anterior olfactory nucleus.	Tsuji T, Tsuji C, Lozic M, Ludwig M, Leng G.	https://doi.org/10.14814/phy2.14284				Physiological Reports
The role of vasopressin in olfactory and visual processing.	Wacker D, Ludwig M.	10.1007/s00441-018-2867-1				Cell and Tissue Research
GnRH antagonists produce differential modulation of the signaling pathways mediated by GnRH receptors	Sperduti S, Limoncella S, Lazzaretti C, Paradiso E, Riccetti L, Turchi S, Ferrigno I, Bertacchini J, Palumbo C, Potì F, Millar RP, Simoni M, Newton CL, Casarini, L.	https://doi.org/10.3390/ijms20225548				International Journal of Molecular Sciences
Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization.	Janse van Vuuren R, Botes M, Jurgens T, Joubert AM, van den Bout I.	https://doi.org/10.1186/s12935-018-0719-4				Cancer Cell International
Small Molecule Follicle-Stimulating Hormone Receptor Agonists and Antagonists.	Anderson RC, Newton CL, Millar RP.	https://doi.org/10.3389/fendo.2018.00757				Frontiers in Endocrinology
Medial Amygdala Kiss1 Neurons Mediate Female Pheromone Stimulation of Luteinizing Hormone in Male Mice.	Aggarwal S, Tang C, Sing K, Kim HW, Millar RP, Tello JA.	https://doi.org/10.1159/000496106				Neuroendocrinology
Similarities and differences in the reproductive phenotypes of women with congenital hypogonadotrophic hypogonadism caused by GNRHR mutations and women with polycystic ovary syndrome.	Maione L, Fèvre A, Nettore IC, Manilall A, Francou B, Trabado S, Bouligand J, Guiochon-Mantel A, Delemer B, Flanagan CA, Macchia PE, Millar RP, Young J.	https://doi.org/10.1093/humrep/dey339				Human Reproduction
Performance of the tuberculin skin test in mycobacterium bovis-exposed and -unexposed African lions (Panthera leo).	Viljoen IM, Sylvester TT, Parsons SDC, Millar RP, Helden PDV, Miller MA.	https://doi.org/10.7589/2018-06-163				Journal of Wildlife Disease
Social rank does not affect sperm quality in male African wild dogs (Lycaon pictus).	Van den Berghe F, Paris MCJ, Sarnyai Z, Briggs MB, Millar RP, Ganswindt A, Paris DBBP	https://doi.org/10.1071/RD18205				Reproduction, Fertility, and Development
Dog appeasing pheromone prevents the androgen surge and may reduce contact dominance and active submission after stressful interventions in African wild dogs (Lycaon pictus).	Van den Berghe F, Paris MCJ, Sarnyai Z, Vlamings B, Millar RP, Ganswindt A, Cozzi A, Pageat P, Paris DBBP.	https://doi.org/10.1371/journal.pone.0212551				PLoS One
Glu2.53(90) of the GnRH receptor is part of the conserved G protein-coupled receptor structure and does not form a salt-bridge with Lys3.32(121).	Manilall A, Stander BA, Madziva MT, Millar RP, Flanagan CA.	https://doi.org/10.1016/j.mce.2018.11.009				Molecular and Cellular Endocrinology
New Developments in Reproductive and Stress Neuroendocrinology	Prevot V, Millar RP.	https://doi.org/10.1159/000502420				Neuuroendocrinology
2018
Gonadotropins and their analogues: current and potential clinical applications.	Anderson RC, Newton CL, Anderson RA, Millar RP.	https://doi.org/10.1210/er.2018-00052				Endocrine Reviews
Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women.	Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA.	https://doi.org/10.1159/000473893				Neuroendocrinology
Stimulation of Growth Hormone by Kisspeptin Antagonists in Ewes.	Smith JT, Roseweir A, Millar M, Clarke IJ, Millar RP.	https://doi.org/10.1530/JOE-18-0074				Journal of Endocrinology
Alterations in male reproductive hormones in relation to environmental DDT exposure.	Bornman M, Delport R, Farías P, Aneck-Hahn N, Patrick S, Millar RP, de Jager C.	https://doi.org/10.1016/j.envint.2017.12.039				Environment International
Continuous Kisspeptin Restores Luteinizing Hormone Pulsatility Following Cessation by a Neurokinin B Antagonist in Female Sheep.	Clarke IJ, Li Q, Henry BA, Millar RP	https://doi.org/10.1210/en.2017-00737				Endocrinology

- Author David van Heerden

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