As we continue to celebrate Women’s Month, we turn our attention to one of the University of Pretoria’s most promising young researchers, Dr. Charlise Basson. Recently completing her PhD, Basson is now taking on a new role as a postdoctoral researcher, where she continues to break new ground in human physiology. Her journey, marked by academic excellence and a deep commitment to advancing healthcare, serves as an inspiring example of what can be achieved through dedication, mentorship, and the pursuit of knowledge.

Basson’s PhD research was focused on understanding the mechanisms of melanoma metastasis. “My research aimed to investigate how specific compounds, particularly CTCE-9908, a CXCR4 inhibitor, and kynurenine metabolites, can inhibit melanoma metastasis. I aspire to produce research that not only advances knowledge but also brings about real, positive change in healthcare,” she explained.

The insights gained from her research have not only contributed to the scientific community’s understanding of melanoma but have also paved the way for Basson’s future work. Now, as a postdoctoral researcher under the guidance of Prof. Melvin Ambele, Basson is exploring the role of obesity in breast cancer metastasis. “I am interested in elucidating the role of obesity in driving breast cancer metastasis. By investigating the molecular and cellular mechanisms involved, I aim to identify novel targets for therapeutic intervention and contribute to a deeper understanding of how obesity may influence cancer outcomes.,” she said.

In addition to her research, Basson plays a crucial role as a part-time lecturer in human physiology, where she brings her cutting-edge research insights into the classroom. “I believe in making the subject matter real and relevant to students by connecting it to ongoing research. When students understand that physiological concepts are not just theoretical but actively being explored to develop therapies, it transforms their learning experience,” she shared.

Balancing her roles as a researcher and educator is something Basson approaches with enthusiasm. “The insights I gain from my research directly inform my teaching. This not only keeps my lectures engaging and current but also helps students see the practical applications of what they’re learning. Teaching, in turn, deepens my understanding of core concepts and enhances my ability to communicate complex ideas clearly—a skill that’s invaluable in research as well,” she reflected.

Basson’s journey has not been without its challenges. She recalls a particularly difficult moment during her PhD when financial constraints threatened the progress of her research. “We encountered significant costs associated with one of our research compounds. To overcome this, we collaborated with the Department of Mathematics to create a mathematical model to predict the compound’s effects on melanoma metastasis. This experience reinforced the importance of persistence and creative problem-solving, lessons that have shaped my approach to research,” she noted.

As she begins her postdoctoral role, Basson is also contributing to the Faculty Biostatistics services, acting as a vital link between the School of Dentistry and the Faculty of Health Sciences. “I’m committed to supporting our research community by improving processes and communication. It’s about ensuring that our collective work continues to thrive and make an impact,” she emphasised.

Basson’s success would not have been possible without the support of the Faculty of Health Sciences, for which she is deeply grateful. “The faculty has been instrumental in shaping my career. I’ve had the privilege of collaborating with experts from various fields, which has been incredibly inspiring. I am profoundly thankful to my mentors and colleagues, whose collective wisdom, eagerness to collaborate, and belief in my potential has been invaluable,” she said.

In honour of Women’s Month, Basson’s story highlights the significant contributions women are making in research and academia. “I have been inspired by the remarkable women who came before me. Their dedication and perseverance remind us that every small step forward is a victory, each incremental success laying the foundation for greater achievements.. We must celebrate each other’s successes and actively promote women’s achievements, creating clear pathways for their advancement,” she urged.

To young women aspiring to enter the field of health sciences, Basson offers this advice: “Believe in your potential. Your unique perspectives and strengths as a woman are invaluable assets. Make it your mission to improve the lives of others, using your strengths to bring empathy, resilience, and determination to your work.”

As Dr. Charlise Basson continues to advance her research career, her story serves as a powerful reminder of the impact women can have in shaping the future of healthcare. The University of Pretoria and the broader scientific community eagerly anticipate the contributions this rising star will make in the years to come.