• Students interested in combining with Zoology in a dual major with Biochemistry or Genetics must take BCM 261 as an elective.
• Students interested in combining Zoology in a dual major with Biochemistry must also replace either BOT 261 or MBY 261 with BCM 262.
Core modules
Module content:
Structural and ionic properties of amino acids. Peptides, the peptide bond, primary, secondary, tertiary and quaternary structure of proteins. Interactions that stabilise protein structure, denaturation and renaturation of proteins. Introduction to methods for the purification of proteins, amino acid composition, and sequence determinations. Introduction to enzyme kinetics and enzyme inhibition. Allosteric enzymes, regulation of enzyme activity, active centres and mechanisms of enzyme catalysis. Examples of industrial applications of enzymes. Practical training in laboratory techniques and Good Laboratory Practice. Techniques for the quantitative and qualitative analysis of biological molecules. Processing and presentation of scientific data.
Module content:
Biochemistry of carbohydrates. Thermodynamics and bioenergetics. Glycolysis, citric acid cycle and electron transport. Glycogen metabolism, pentose-phosphate pathway, gluconeogenesis and photosynthesis. Practical training in study and analysis of metabolic pathways and enzymes. Scientific method and design: Hypothesis design and testing, method design and scientific controls.
Module content:
Origin and affinity of South African flora and vegetation types; principles of plant geography; plant diversity in southern Africa; characteristics, environments and vegetation of South African biomes and associated key ecological processes; centra of plant endemism; rare and threatened plant species; biodiversity conservation and ecosystem management; invasion biology; conservation status of South African vegetation types.
Module content:
Nitrogen metabolism in plants; nitrogen fixation in Agriculture; plant secondary metabolism and natural products; photosynthesis and carbohydrate metabolism in plants; applications in solar energy; plant growth regulation and the Green Revolution; plant responses to the environment; developing drought tolerant and disease resistant plants.
Module content:
This module will give an overview of earth history, from the Archaean to the present. Important concepts such as the principles of stratigraphy and stratigraphic nomenclature, geological dating and international and South African time scales will be introduced. A brief introduction to the principles of palaeontology will be given, along with short descriptions of major fossil groups, fossil forms, ecology and geological meaning. In the South African context, the major stratigraphic units, intrusions and tectonic/metamorphic events will be detailed, along with related rock types, fossil contents, genesis and economic commodities. Practical work will focus on the interpretation of geological maps and profiles.
Module content:
Chemical nature of DNA. Replication transcription, RNA processing and translation. Control of gene expression in prokaryotes and eukaryotes. Recombinant DNA technology and its applications in gene analysis and manipulation.
Module content:
Chromosome structure and transposable elements. Mutation and DNA repair. Genomics and proteomics. Organelle genomes. Introduction to genetic analysis of populations: allele and genotypic frequencies, Hardy Weinberg Law, its extensions and implications for different mating systems. Introduction to quantitative and evolutionary genetics.
Module content:
Growth, replication and survival of bacteria, Energy sources, harvesting from light versus oxidation, regulation of catabolic pathways, chemotaxis. Nitrogen metabolism, iron-scavenging. Alternative electron acceptors: denitrification, sulphate reduction, methanogenesis. Bacterial evolution, systematic and genomics. Biodiversity; bacteria occurring in the natural environment (soil, water and air), associated with humans, animals, plants, and those of importance in foods and in the water industry.
Module content:
Organisation and molecular architecture of fungal thalli, chemistry of the fungal cell. Chemical and physiological requirements for growth and nutrient acquisition. Mating and meiosis; spore development; spore dormancy, dispersal and germination. Fungi as saprobes in soil, air, plant, aquatic and marine ecosystems; role of fungi as decomposers and in the deterioration of materials; fungi as predators and parasites; mycoses, mycetisms and mycotoxicoses; fungi as symbionts of plants, insects and animals. Applications of fungi in biotechnology.
Module content:
Origin and extent of modern invertebrate diversity; parasites of man and domestic animals; biology and medical importance of arachnids; insect life styles; the influence of the environment on insect life histories; insect phytophagy, predation and parasitism; insect chemical, visual, and auditory communication; freshwater invertebrates and their use as biological indicators.
Module content:
Introduction to general vertebrate diversity; African vertebrate diversity; vertebrate structure and function; vertebrate evolution; vertebrate relationships; aquatic vertebrates; terrestrial ectotherms; terrestrial endotherms; vertebrate characteristics; classification; structural adaptations; habits; habitats; conservation problems; impact of humans on other vertebrates.
Elective modules
Module content:
Biochemistry of lipids, membrane structure, anabolism and catabolism of lipids. Nitrogen metabolism, amino acid biosynthesis and catabolism. Biosynthesis of neurotransmitters, pigments, hormones and nucleotides from amino acids. Catabolism of pureness and pyrimidines. Therapeutic agents directed against nucleotide metabolism. Examples of inborn errors of metabolism of nitrogen containing compounds. The urea cycle, nitrogen excretion. Practical training in scientific writing skills: evaluation of a scientific report. Techniques for separation and analysis of biological molecules
Module content:
Biochemistry of nutrition and toxicology. Proximate analysis of nutrients. Review of energy requirements and expenditure. Respiratory quotient. Requirements and function of water, vitamins and minerals. Interpretation and modification of RDA values for specific diets, eg growth, exercise, pregnancy and lactation, aging and starvation. Interactions between nutrients. Comparison of monogastric and ruminant metabolism. Cholesterol, polyunsaturated, essential fatty acids and dietary anti-oxidants. Oxidation of fats. Biochemical mechanisms of water- and fat-soluble vitamins and assessment of vitamin status. Mineral requirements, biochemical mechanisms, imbalances and diarrhoea. Biochemistry of xenobiotics: absorption, distribution, metabolism and excretion (ADME); detoxification reactions: oxidation/reduction (Phase I), conjugations (Phase II), export from cells (Phase III); factors affecting metabolism and disposition. Toxic responses: tissue damage and physiological effects, teratogenesis, immunotoxicity, mutagenesis and carcinogenesis. Examples of toxins: biochemical mechanisms of common toxins and their antidotes. Antibiotics and resistance. Natural toxins from fungi, plants and animals: goitrogens, cyanogens, cholineesterase inhibitors, ergotoxin, aflatoxins Practical training in analyses of nutrients, fatty acids separations, antioxidant determination, and enzyme activity measurements, PO ratio of mitochondria, electrophoresis, extraction, solubility and gel permeation techniques.
Module content:
Origin and development of soil, weathering and soil formation processes. Profile differentiation and morphology. Physical characteristics: texture, structure, soil water, atmosphere and temperature. Chemical characteristics: clay minerals, ion exchange, pH, buffer action, soil acidification and salinisation of soil. Soil fertility and fertilisation. Soil classification. Practical work: Laboratory evaluation of simple soil characteristics. Field practicals on soil formation in the Pretoria area.
Module content:
Primary sources of migroorganisims in food. Factors affecting the growth and survival of microorganisms in food. Microbial quality, spoilage and safety of food. Different organisms involved, their isolation, screening and detection. Conventional approaches, alternative methods rapid methods. Food fermentations: fermentation types, principles and organisms involved.
Module content:
Development and importance of crop protection. Basic principles in crop protection i.e. epidemic development of disease and insect pest populations, ecology of plant diseases and abiotic factors that affect plant health i.e. environmental pollution and pesticides, nutrient deficiencies and extreme environmental conditions. Ecological aspects of plant diseases, pest outbreaks and weed invasion. Important agricultural pests and weeds. Life cycles of typical disease causing organisms. Basic principles of integrated pest and disease management.
Module content:
Fundamental principles of plant pathology. The concept of disease in plants. Causes of plant diseases. Stages in development of plant diseases. Disease cycles. Diagnosis of plant diseases.