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Find, evaluate, process, manage and present information resources for academic purposes using appropriate technology. Apply effective search strategies in different technological environments. Demonstrate the ethical and fair use of information resources. Integrate 21st-century communications into the management of academic information.

Module content:

Find, evaluate, process, manage and present information resources for academic purposes using appropriate technology.

Module content:

Apply effective search strategies in different technological environments. Demonstrate the ethical and fair use of information resources. Integrate 21st-century communications into the management of academic information.

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The module aims to equip students with the ability to cope with the reading and writing demands of scientific disciplines. 

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Simple statistical analysis: Data collection and analysis: Samples, tabulation, graphical representation, describing location, spread and skewness. Introductory probability and distribution theory. Sampling distributions and the central limit theorem. Statistical inference: Basic principles, estimation and testing in the one- and two-sample cases (parametric and non-parametric). Introduction to experimental design. One- and twoway designs, randomised blocks. Multiple statistical analysis: Bivariate data sets: Curve fitting (linear and non-linear), growth curves. Statistical inference in the simple regression case. Categorical analysis: Testing goodness of fit and contingency tables. Multiple regression and correlation: Fitting and testing of models. Residual analysis. Computer literacy: Use of computer packages in data analysis and report writing.

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Basic plant structure and function; introductory plant taxonomy and plant systematics; principles of plant molecular biology and biotechnology; adaptation of plants to stress; medicinal compounds from plants; basic principles of plant ecology and their application in natural resource management.

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General introduction to inorganic, analytical and physical chemistry. Atomic structure and periodicity. Molecular structure and chemical bonding using the VSEOR model. Nomenclature of inorganic ions and compounds. Classification of reactions: precipitation, acid-base, redox reactions and gas-forming reactions. Mole concept and stoichiometric calculations concerning chemical formulas and chemical reactions. Principles of reactivity: energy and chemical reactions. Physical behaviour gases, liquids, solids and solutions and the role of intermolecular forces. Rate of reactions: Introduction to chemical kinetics.

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Theory: General physical-analytical chemistry: Chemical equilibrium, acids and bases, buffers, solubility equilibrium, entropy and free energy, electrochemistry. Organic chemistry: Structure (bonding), nomenclature, isomerism, introductory stereochemistry, introduction to chemical reactions and chemical properties of organic compounds and biological compounds, i.e. carbohydrates and aminoacids. Practical: Molecular structure (model building), synthesis and properties of simple organic compounds.

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Chromosomes and cell division. Principles of Mendelian inheritance: locus and alleles, dominance interactions and epistasis. Probability studies. Sex determination and sex linked traits. Pedigree analysis. Extranuclear inheritance. Genetic linkage and chromosome mapping. Chromosome variation.

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The module will introduce the student to the field of Microbiology. Basic Microbiological aspects that will be covered include introduction into the diversity of the microbial world (bacteria, archaea, eukaryotic microorganisms and viruses), basic principles of cell structure and function, microbial nutrition and microbial growth and growth control. Applications in Microbiology will be illustrated by specific examples i.e. bioremediation, animal-microbial symbiosis, plant-microbial symbiosis and the use of microorganisms in industrial microbiology. Wastewater treatment, microbial diseases and food will be introduced using specific examples.

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Introductory study of the ultra structure, function and composition of representative cells and cell components. General principles of cell metabolism, molecular genetics, cell growth, cell division and differentiation.

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Units, vectors, one dimensional kinematics, dynamics, work, equilibrium, sound, liquids, heat, thermodynamic processes, electric potential and capacitance, direct current and alternating current, optics, modern physics, radio activity.

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*Students will not be credited for more than one of the following modules for their degree: WTW 134, WTW 165, WTW 114, WTW 158. WTW 134 does not lead to admission to Mathematics at 200 level and is intended for students who require Mathematics at 100 level only. WTW 134 is offered as WTW 165 in the second semester only to students who have applied in the first semester of the current year for the approximately 65 MBChB, or the 5-6 BChD places becoming available in the second semester and who were therefore enrolled for MGW 112 in the first semester of the current year. 
Functions, derivatives, interpretation of the derivative, rules of differentiation, applications of differentiation, integration, interpretation of the definite integral, applications of integration. Matrices, solutions of systems of equations. All topics are studied in the context of applications.

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Animal classification, phylogeny, organization and terminology. Evolution of the various animal phyla, morphological characteristics and life cycles of parasitic and non-parasitic animals. Structure and function of reproductive, respiratory, excretory, circulatory and digestive systems.

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Structural and ionic properties of amino acids. Peptides, the peptide bond, primary, secondary, tertiary and quaternary structure of proteins. Interactions that stabilise protein structure, denaturation and renaturation of proteins. Introduction to methods for the purification of proteins, amino acid composition, and sequence determinations. Introduction to enzyme kinetics and enzyme inhibition. Allosteric enzymes, regulation of enzyme activity, active centres and mechanisms of enzyme catalysis. Examples of industrial applications of enzymes. Practical training in laboratory techniques and Good Laboratory Practice. Techniques for the quantitative and qualitative analysis of biological molecules. Processing and presentation of scientific data.

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Biochemistry of carbohydrates. Thermodynamics and bioenergetics. Glycolysis, citric acid cycle and electron transport. Glycogen metabolism, pentose-phosphate pathway, gluconeogenesis and photosynthesis. Practical training in study and analysis of metabolic pathways and enzymes. Scientific method and design: Hypothesis design and testing, method design and scientific controls.

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Origin and affinity of South African flora and vegetation types; principles of plant geography; plant diversity in southern Africa; characteristics, environments and vegetation of South African biomes and associated key ecological processes; centra of plant endemism; rare and threatened plant species; biodiversity conservation and ecosystem management; invasion biology; conservation status of South African vegetation types.

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Nitrogen metabolism in plants; nitrogen fixation in Agriculture; plant secondary metabolism and natural products; photosynthesis and carbohydrate metabolism in plants; applications in solar energy; plant growth regulation and the Green Revolution; plant responses to the environment; developing drought tolerant and disease resistant plants.

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This module will give an overview of earth history, from the Archaean to the present. Important concepts such as the principles of stratigraphy and stratigraphic nomenclature, geological dating and international and South African time scales will be introduced. A brief introduction to the principles of palaeontology will be given, along with short descriptions of major fossil groups, fossil forms, ecology and geological meaning. In the South African context, the major stratigraphic units, intrusions and tectonic/metamorphic events will be detailed, along with related rock types, fossil contents, genesis and economic commodities. Practical work will focus on the interpretation of geological maps and profiles.

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Chemical nature of DNA. Replication transcription, RNA processing and translation. Control of gene expression in prokaryotes and eukaryotes.  Recombinant DNA technology and its applications in gene analysis and manipulation.

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Chromosome structure and transposable elements. Mutation and DNA repair. Genomics and proteomics. Organelle genomes. Introduction to genetic analysis of populations: allele and genotypic frequencies, Hardy Weinberg Law, its extensions and implications for different mating systems. Introduction to quantitative and evolutionary genetics.

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Growth, replication and survival of bacteria, Energy sources, harvesting from light versus oxidation, regulation of catabolic pathways, chemotaxis. Nitrogen metabolism, iron-scavenging. Alternative electron acceptors: denitrification, sulphate reduction, methanogenesis.  Bacterial evolution, systematic and genomics. Biodiversity; bacteria occurring in the natural environment (soil, water and air), associated with humans, animals, plants, and those of importance in foods and in the water industry.

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Organisation and molecular architecture of fungal thalli, chemistry of the fungal cell. Chemical and physiological requirements for growth and nutrient acquisition. Mating and meiosis; spore development; spore dormancy, dispersal and germination. Fungi as saprobes in soil, air, plant, aquatic and marine ecosystems; role of fungi as decomposers and in the deterioration of materials; fungi as predators and parasites; mycoses, mycetisms and mycotoxicoses; fungi as symbionts of plants, insects and animals. Applications of fungi in biotechnology.

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Origin and extent of modern invertebrate diversity; parasites of man and domestic animals; biology and medical importance of arachnids; insect life styles; the influence of the environment on insect life histories; insect phytophagy, predation and parasitism; insect chemical, visual, and auditory communication; freshwater invertebrates and their use as biological indicators.

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Introduction to general vertebrate diversity; African vertebrate diversity; vertebrate structure and function; vertebrate evolution; vertebrate relationships; aquatic vertebrates; terrestrial ectotherms; terrestrial endotherms; vertebrate characteristics; classification; structural adaptations; habits; habitats; conservation problems; impact of humans on other vertebrates.

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Biochemistry of lipids, membrane structure, anabolism and catabolism of lipids. Nitrogen metabolism, amino acid biosynthesis and catabolism. Biosynthesis of neurotransmitters, pigments, hormones and nucleotides from amino acids. Catabolism of pureness and pyrimidines. Therapeutic agents directed against nucleotide metabolism. Examples of inborn errors of metabolism of nitrogen containing compounds. The urea cycle, nitrogen excretion. Practical training in scientific writing skills: evaluation of a scientific report. Techniques for separation and analysis of biological molecules

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Biochemistry of nutrition and toxicology. Proximate analysis of nutrients. Review of energy requirements and expenditure. Respiratory quotient. Requirements and function of water, vitamins and minerals. Interpretation and modification of RDA values for specific diets, eg growth, exercise, pregnancy and lactation, aging and starvation. Interactions between nutrients. Comparison of monogastric and ruminant metabolism. Cholesterol, polyunsaturated, essential fatty acids and dietary anti-oxidants. Oxidation of fats. Biochemical mechanisms of water- and fat-soluble vitamins and assessment of vitamin status. Mineral requirements, biochemical mechanisms, imbalances and diarrhoea. Biochemistry of xenobiotics: absorption, distribution, metabolism and excretion (ADME); detoxification reactions: oxidation/reduction (Phase I), conjugations (Phase II), export from cells (Phase III); factors affecting metabolism and disposition. Toxic responses: tissue damage and physiological effects, teratogenesis, immunotoxicity, mutagenesis and carcinogenesis. Examples of toxins: biochemical mechanisms of common toxins and their antidotes. Antibiotics and resistance. Natural toxins from fungi, plants and animals: goitrogens, cyanogens, cholineesterase inhibitors, ergotoxin, aflatoxins  Practical training in analyses of nutrients, fatty acids separations, antioxidant determination, and enzyme activity measurements, PO ratio of mitochondria, electrophoresis, extraction, solubility and gel permeation techniques.

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Origin and development of soil, weathering and soil formation processes. Profile differentiation and morphology. Physical characteristics: texture, structure, soil water, atmosphere and temperature. Chemical characteristics: clay minerals, ion exchange, pH, buffer action, soil acidification and salinisation of soil. Soil fertility and fertilisation. Soil classification. Practical work: Laboratory evaluation of simple soil characteristics. Field practicals on soil formation in the Pretoria area.

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Primary sources of migroorganisims in food. Factors affecting the growth and survival of microorganisms in food. Microbial quality, spoilage and safety of food. Different organisms involved, their isolation, screening and detection. Conventional approaches, alternative methods rapid methods. Food fermentations: fermentation types, principles and organisms involved.

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Development and importance of crop protection. Basic principles in crop protection i.e. epidemic development of disease and insect pest populations, ecology of plant diseases and abiotic factors that affect plant health i.e. environmental pollution and pesticides, nutrient deficiencies and extreme environmental conditions. Ecological aspects of plant diseases, pest outbreaks and weed invasion. Important agricultural pests and weeds. Life cycles of typical disease causing organisms. Basic principles of integrated pest and disease management.

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Fundamental principles of plant pathology. The concept of disease in plants. Causes of plant diseases. Stages in development of plant diseases. Disease cycles. Diagnosis of plant diseases.

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Scientific approach to ecology; evolution and ecology; the individual and its environment; population characteristics and demography; competition; predation; plant-herbivore interactions; regulation of populations; population manipulation.

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Mammalian origins and their characteristics: evolution of African mammals; structure and function: integument, support and movement; foods and feeding; environmental adaptations; reproduction; behaviour; ecology and biogeography; social behaviour; sexual selection; parental care and mating systems; community ecology; zoogeography. Special topics: parasites and diseases; domestication and domesticated mammals; conservation.

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The scientific approach; characteristics of the community; the community as a superorganism; community changes; competition as a factor determining community structure; disturbance as a determinant of community structure; community stability; macroecological environmental gradients and communities. A field trip will be conducted during the September vacation to the Sani Pass region of the Maloti-Drakensberg Mountains.
 

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This module focuses on the integration of physiological systems in the context of animal form and function, and the ways in which evolution shapes the physiological processes that determine the energy, water and nutrient fluxes between animals and their environments. Topics covered include: (i) circulation, gas exchange and excretion; (ii) nutritional ecology; (iii) osmoregulation and thermoregulation; and (iv) reproductive physiology. The major focus of this module is to understand the major sources of physiological diversity, namely scaling, phylogenetic inertia, adaptation and phenotypic plasticity, and applying this knowledge to conceptually link physiological processes at the cellular level to macrophysiological patterns at a global scale.

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This module focuses on the means by which animals can sense and respond to the external and internal environment. Topics covered include: (i) the structure and function of biological membranes; (ii) neurons and nervous systems; (iii) sensing the environment; (iv) glands, hormones and regulation of development and growth; (v) muscles and animal movement and (vi) the initiation and control of behaviour. The implications of these physiological processes for animal conservation and management will be emphasised. A comparative approach will be adopted throughout the module to highlight the commonalities as well as the ways in which animal lineages have achieved similar functional outcomes from different structural adaptations.

Module content:

Evolution as a process and pattern, prime movers in evolution: Selection, drift, general population genetics. Population differentiation, clines, subspecies and species, adaptation as a major force in evolution and the panglossian paradigm, molecular evolution. Phylogeography, phylogenetic reconstruction. Evolutionary biogeography. Adaptation, Darwin's formulation, proximate and ultimate causation, genetic and developmental constraints, optimality. Phenotypic models, the comparative method, convergent evolution. Evolution of complex biological systems, origin of life and sex, macro-evolution, punctuated equilibrium, human evolution. Levels of selection. Species concepts.

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The history of behavioural ecology. A causal, developmental, evolutionary and adaptive approach. Sensory systems and communication. Sexual selection, mate choice and sperm competition. Kin selection and group living. Special reference to social insects. The behavioural ecology of humans. Phylogenetic basis of behavioural analysis. The role of behavioural ecology in conservation planning.

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This module is intended to provide students with the skills and knowledge that are essential for the conservation of biodiversity. The module focuses on conservation theory and practice (e.g. endangered species, habitat loss, overexploitation, climate change), and has a practical component. The students will be actively involved in planning and executing field projects, and will be responsible for analysing and presenting the results. The students will gain valuable theoretical and practical experience in the field of conservation ecology by being exposed to a number of different taxa.