Jaarboeke

Biokatalisering en integrasie van metabolisme 357


 
Modulekode BCM 357
Kwalifikasie Voorgraads
Fakulteit Fakulteit Natuur- en Landbouwetenskappe
Module-inhoud

* Hierdie inligting is slegs in Engels beskikbaar.

Nomenclature: enzyme nomenclature and classification. Specificity and mechanisms: the active site, mechanisms of catalysis and examples of specific enzyme mechanisms, e.g. lysozyme and carboxypeptidase A. Advanced enzyme kinetics, Cleland nomenclature and multi-substrate reactions. Allosteric enzymes: models by Koshland, Hill and Monod. Ligands binding to proteins. Problems and answers: tutorials of problems and answers based on above concepts. Integration of metabolism; hormones and second messengers; cell signalling; a case study in connectivity among metabolic pathways and their regulation, in for example diabetes and starvation. Inhibitors of angiotensin converting enzyme (ACE). RNA as enzymes. Applications of enzymes in food and cosmetics industries and in clinical pathology assays as biomarkers of diseases and toxic responses. Elucidation of metabolic pathways.
Practical sessions cover tutorials on calculations, isolation of an enzyme, determination of pH and temperature optimum, determination of Km and Vmax, enzyme activation, enzyme inhibition, purification table and final report, oral defense of report.

Modulekrediete 18.00
Voorvereistes BCM 251 en BCM 252 en BCM 261
Kontaktyd 2 lesings per week, 1 praktiese sessie per week
Onderrigtaal Afrikaans en Engels word in een klas gebruik
Departement Biochemie
Aanbiedingstydperk Semester 1

Die inligting wat hier verskyn, is onderhewig aan verandering en kan na die publikasie van hierdie inligting gewysig word.. Die Algemene Regulasies (G Regulasies) is op alle fakulteite van die Universiteit van Pretoria van toepassing. Dit word vereis dat elke student volkome vertroud met hierdie regulasies sowel as met die inligting vervat in die Algemene Reëls sal wees. Onkunde betrefffende hierdie regulasies en reels sal nie as ‘n verskoning by oortreding daarvan aangebied kan word nie.

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