Jaarboeke

Macromolekules van die lewe: struktuurfunksie en bioinformatika 356


 
Modulekode BCM 356
Kwalifikasie Voorgraads
Fakulteit Fakulteit Natuur- en Landbouwetenskappe
Module-inhoud

* Hierdie inligting is slegs in Engels beskikbaar.

Perspectives on the flow of information from nucleic acids to proteins, the structure and functions of nucleic acids and proteins and their organisation into hierarchical, interdependent systems. Nucleic acid structure as observed in fibres and crystals as well as global DNA and RNA analyses (methods and bioinformatic analyses). Biochemical analyses of nucleotides. DNA-DNA recognition: non-standard and higher order DNA structures. The RNA structural world, RNAi, miRNA and ribosomes. Cellular functions of coding and non-coding nucleic acids. Principles of small molecule-DNA recognition. Principles of protein-DNA recognition and interactions. Bioinformatics predictions of protein and small molecule DNA interactions. Chemical reactivity of amino acids. Domain structures of proteins and Ramachandran plots. Protein folding, sequence motifs and domains, higher order and supramolecular structure, self-assembly, conjugated proteins, post-translational modifications, conjugated proteins and bioinformatics predictions. Principles of protein function and protein structure relationships. Protein-ligand and protein-protein interactions. Protein aggregation in disease. Examples of the diverse functions of proteins and peptides, including enzymes, hormones, neurotransmitters, antibodies, receptors, transport and membrane proteins. Global analysis of proteins through proteomics. Basic principles of nuclear magnetic resonance, mass spectrometry and X-ray crystallography. Protein purification and characterization including, pI, molecular mass, amino acid composition and sequence. Practical training will include interactive computer-guided demonstrations of protein analysis, hands-on practical sessions for nucleic acid purification and chemical structure characterisation, protein expression and purification (including SDS-PAGE), protein sequence analysis including mass spectrometry, protein structure analysis by 3D protein modelling and protein folding (Bioinformatics).

Modulekrediete 18.00
Voorvereistes BCM 251 en BCM 252
Kontaktyd 1 praktiese sessie per week, 2 lesings per week
Onderrigtaal Afrikaans en Engels word in een klas gebruik
Departement Biochemie
Aanbiedingstydperk Semester 1

Die inligting wat hier verskyn, is onderhewig aan verandering en kan na die publikasie van hierdie inligting gewysig word.. Die Algemene Regulasies (G Regulasies) is op alle fakulteite van die Universiteit van Pretoria van toepassing. Dit word vereis dat elke student volkome vertroud met hierdie regulasies sowel as met die inligting vervat in die Algemene Reëls sal wees. Onkunde betrefffende hierdie regulasies en reels sal nie as ‘n verskoning by oortreding daarvan aangebied kan word nie.

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