Evolution as a process and pattern, prime movers in evolution: Selection, drift, general population genetics. Population differentiation, clines, subspecies and species, adaptation as a major force in evolution and the panglossian paradigm, molecular evolution. Phylogeography, phylogenetic reconstruction. Evolutionary biogeography. Adaptation, Darwin's formulation, proximate and ultimate causation, genetic and developmental constraints, optimality. Phenotypic models, the comparative method, convergent evolution. Evolution of complex biological systems, origin of life and sex, macro-evolution, punctuated equilibrium, human evolution. Levels of selection. Species concepts.