Publications from the past five years

Anderson RC, Newton CL, Anderson RA, Millar RP. (2018) Gonadotropins and their analogues: current and potential clinical applications. Endocr. Rev. er.2018-00052. [Epub ahead of print].

Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA. (2018) Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women. Neuroendocrinology. 106:148–157.

Smith JT, Roseweir A, Millar M, Clarke IJ, Millar RP. (2018)
Stimulation of Growth Hormone by Kisspeptin Antagonists in Ewes. J Endocrinol. 237(2):165-173. 

Bornman M, Delport R, Farías P, Aneck-Hahn N, Patrick S, Millar RP, de Jager C. Alterations in male reproductive hormones in relation to environmental DDT exposure. (2018) Environ Int. pii: S0160-4120(17)31639-2. [Epub ahead of print].

Clarke IJ, Li Q, Henry BA, Millar RP (2018) Continuous Kisspeptin Restores Luteinizing Hormone Pulsatility Following Cessation by a Neurokinin B Antagonist in Female Sheep. Endocrinology 159(2):639-646.

Millar RP, Sonigo C, Anderson RA, George J, Maione L, Brailly-Tabard S, Chanson P, Binart N, Young J (2017) Hypothalamic-Pituitary-Ovarian Axis reactivation by Kisspeptin-10 in hyperprolactinemic women with chronic amenorrhea. Journal of Endocrine Society 1(11):1362-1371.

Sonigo C, Bouilly J, Carre N, Tolle V, Caraty A, Tello J, Simony-Conesa FJ, Millar RP, Yound J, Binart N (2017) Hyperprolactinemia-induced ovarian acyclicity is reversed by Kisspeptin administration. J. Clin. Investig 122(10):3791-3795

Pineda R, Plaisier F, Millar RP, Ludwig M (2017) Amygdala Kisspeptin Neurons: Putative Mediators of Olfactory Control of the Gonadotropic Axis. Neuroendocrinology 104(3):223-238.

Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA (2017) Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women. Neuroendocrinology. [Epub ahead of print]

Flacke GL, Schwarzenberger F, Penfold LM, Walker SL, Martin GB, Millar RP, Paris MCJ (2017) Characterizing the reproductive biology of the female pygmy hippopotamus (Choeropsis liberiensis) through non-invasive endocrine monitoring. Theriogenology 15;102:126-138.

Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA (2017) Neurokinin 3 receptor antagonism decreases gonadotropin and testosterone secretion in healthy men. Clin Endocrinol (Oxf) 87(6):748-756.

Fabre-Nys C, Cognié J, Dufourny L, Ghenim M, Martinet S, Lasserre O, Lomet D, Millar RP, Ohkura S, Suetomi Y (2017) The Two Populations of Kisspeptin Neurons Are Involved in the Ram-Induced LH Pulsatile Secretion and LH Surge in Anestrous Ewes. Endocrinology 158(11):3914-3928. doi: 10.1210/en.2017-00429.

Visagie MH, van den Bout I, Joubert AM (2017) A bis-sulphamoylated estradiol derivative induces ROS-dependent cell cycle abnormalities and subsequent apoptosis. PLoS one 12(4): e0176006.

Albers-Wolthers C, de Gier J, Walen M, van Kooten P, Lambalk C, Leegwater P, Roelen B, Schaefers-Okkens A, Rutten V, Millar R, Kooistra H. (2017) In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation. PLoS one. 12(6):e0179156.

George J, Hendrikse M, Veldhuis J, Clarke I, Anderson R, Millar R. (2017) Effect of gonadotropin-inhibitory hormone on luteinizing hormone secretion in humans. Clinical Endocrinology. 86(5):731-738.

Skorupskaite K, George J, Veldhuis J, Millar R, Anderson R. (2017) Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women. Neuroendocrinology.

Visuttijai K, Pettersson J, Azar YM, van den Bout I, Örndal C, Marcickiewicz J, Nilsson S, Hörnquist M, Olsson B, Ejeskär K, and Behboudi A. (2016) Lowered expression of tumor suppressor candidate MYO1C stimulates cell proliferation, suppresses cell adhesion and activates AKT. PLoS one. 11(10):e0164063).

Newton C, Wood M, Strange P. (2016) Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors. PLoS one. 11(7):e0158808.

Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA. (2016) Interactions between neurokinin B and kisspeptin in mediating estrogen feedback in healthy women. J Clin Endocrinol Metab. 101:4628-4636

Newton CL, Anderson RC, Katz AA, Millar RP. (2016) Loss of function mutations in the human luteinizing hormone receptor predominantly cause intracellular retention. Endocrinology. 157:4364-4377

Barranco JA, Millar RP, Fuentes F, Bover E, Pimentel E, Basulto R, Calzada L, Morán R, Rodríguez A, Garay H, Reyes O, Castro MD, Bringas R, Arteaga N, Toudurí H, Rabassa M, Fernández Y, Serradelo A, Hernández E, Guillén GE. (2016) Gradual reduction of testosterone using a gonadotropin-releasing hormone vaccination delays castration resistance in a prostate cancer model. Oncol Lett. 12:963-970.

Raimondo JV, Tomes H, Irkle A, Kay L, Kellaway L, Markram H, Millar RP, Akerman CJ. (2016) Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors. J Neurosci. 36:7002-13.

Pineda R, Plaisier F, Millar RP, Ludwig M. (2016) Amygdala Kisspeptin Neurons: Putative Mediators of Olfactory Control of the Gonadotropic Axis. Neuroendocrinology. [Epub ahead of print]

Pineda R, Sabatier N, Ludwig M, Millar RP, Leng G. (2016) A Direct Neurokinin B Projection from the Arcuate Nucleus Regulates Magnocellular Vasopressin Cells of the Supraoptic Nucleus. J Neuroendocrinol. 28

Newton CL, Anderson RC, Millar RP. (2016) Therapeutic Neuroendocrine Agonist and Antagonist Analogs of Hypothalamic Neuropeptides as Modulators of the Hypothalamic-Pituitary-Gonadal Axis. Endocr Dev. 30:106-29.

van der Goot AC, Martin GB, Millar RP, Paris MC, Ganswindt A. (2015) Profiling patterns of fecal 20-oxopregnane concentrations during ovarian cycles in free-ranging southern white rhinoceros (Ceratotherium simum simum). Anim Reprod Sci. 161:89-95.

Fraser GL, Hoveyda HR, Clarke IJ, Ramaswamy S, Plant TM, Rose C, Millar RP. (2015) The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 156:4214-25.

Zmora N, Stubblefield JD, Wong TT, Levavi-Sivan B, Millar RP, Zohar Y. (2015) Kisspeptin Antagonists Reveal Kisspeptin 1 and Kisspeptin 2 Differential Regulation of Reproduction in the Teleost, Morone saxatilis. Biol Reprod. 93:76.

Li Q, Millar RP, Clarke IJ, Smith JT. (2015) Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep. Neuroendocrinology. 101:161-74.

Viljoen IM,  van Helden  PD,  Millar RP. (2015). Mycobacterium bovis infection in the lion (Panthera leo): Current knowledge, conundrums and research challenges.  Vet Micro. 177(3-4): 252-60

Mayevu NM, Choe H, Abagyan R, Seong JY, Millar RP, Katz AA, Flanagan CA. (2015). Histidine 7.36 (305) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation. Mol Cell Endocrinol . 402: 95-106.

Millar RP, Babwah AV. (2015). KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis. Neuroendocrinol. (DOI:10.1159/000381457)

Moon MJ, Lee YN, Park S, Reyes-Alcaraz A, Hwang JI, Millar RP, Choe H, Seong JY. (2015). Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain. J Biol Chem. 290: 5696-5706.

Millar RP. (2014). Identification of genuine/authentic leptin: some answers and more questions.  Endocrinol. 155(9): 3203-3205

Karampelas T, Argyros O, Sayyad N, Spyridaki K, Pappas C, Morgan K, Kolios G, Millar RP, Liapakis G, Tzakos AG, Fokas D, Tamvakopoulos C. (2014). GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery. Bioconjug Chem 25(4):813-23.

Millar RP. (2014). New developments in kisspeptin, neurokinin B and dynorphin a regulation of gonadotropin-releasing hormone pulsatile secretion. Neuroendocrinology.99(1):5-6.

Albers-Wolthers CH, De Gier J, Kooistra HS, Rutten VP, van Kooten PJ, de Graaf JJ, Leegwater PA, Millar RP, Okkens AC. (2014). Identification of a Novel Kisspeptin with High Gonadotropin Stimulatory activity in the dog. Neuroendocrinology.99:178-189.

Francis VA, Abera AB, Matjila M, Millar RP, Katz AA. (2014). Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. PLoS one.9(6):e99680.

van Kesteren F, Piggott KJ, Bengui T, Kubri SB, Mastin A, Sillero-Zubiri C, Paris M, Millar RP, Macdonald DW, Shiferaw F, Craig PS. (2014). Helminth parasites in the endangered Ethiopian wolf, Canis Simensis. J Helminthol.9:1-9.

Verma S, Kirigiti M, Millar RP, Grove KL, Smith SM. (2014). Endogenous Kisspeptin Tone is a critical excitatory component of spontaneous GnRH activity and the GnRH response to NPY and CART. Neuroendocrinology. 99:190-203.

Anderson RC, Newton CL, Millar RP, Katz AA. (2014). The Brugia malayi neuropeptide receptor -4 is activated by FMR Famide-like peptides and signals via Gai. Mol Biochem Parasitol.195(1) :54-58.

Popovics P, Lu J, Nadia Kamil L, Morgan K, Millar RP, Schmid R, Blindauer CA, Stewart AJ. (2014). A canonical EF-loop directs Ca(2+) - sensitivity in phosphokipase C-ή2 J Cell Biochem.115(3) :557-65

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawcenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. (2014). Reprint of: Policy decision on endocrine disruptors should be based on science across disciplines: A response to Dietrich, et.al. Front Neuroendocrinol.35(1) :2-5

Theron AE, Lafanechere L, Prudent R, Nolte E, van den Bout I, Puchoo R, Marais S, Du Toit P, Hlope Y, van Papendorp D, and Joubert AM. (2014) Novel in silico-designed estradiol analogues display cytotoxicity in a multidrug resistant cell line at nanomolar concentrations. Cancer Chemotherapy and Pharmacology. 75(2): 431-437.

Munro KI, Thrippleton MJ, Williams AR, McKillop G, Walker J, Horne AW, Newby DE, Anderson RA, Semple SI, Marshall I, Lewis SC, Millar RP, Bastin ME, Critchley HO. (2014). Quantitive Serial MRI of the Treated Fibroid Uterus. PLoS one, 9(3) :89809

Grachev P, Millar RP, O’Byrne KT. (2013). The role of neurokinin B signalling in reproductive neuroendocrinology. Neuroendocrinology.99(1) :7-17

Knoll JG, Clay CM, Bouma GJ, Henion TR, Schwarting GA, Millar RP, Tobet SA. (2013). Developmental profile and sexually dimorphic expression of kiss1 and kiss1r in the fetal mouse brain. Front Endocrinol (Lausanne)4:140-146

Ubuka T, Son YL, Bentley GE, Millar RP, Tsutsui K (2013). Gondotropin-inhibitory hormone (GnlH) , GnlH receptor and cell signalling. Gen Comp Endocrinol, 190:10-17.

Roseweir AK, Millar RP (2013). Kisspeptin Antagonists. Adv Exp Med Biol, 784:159-86.

Giandomenico V, Modlin IM, Pontén F, Nilsson M, Landegren U, Bergqvist J, Khan MS, Millar RP, Langström B, Borlak J, Eriksson B, Nielsen B, Baltzer L, Waterton JC, Ahlström H, Ohberg K (2013). Improving the diagnosis and management of neuroendocrine tumors: utilizing new advances in biomarker and molecular imaging science. Neuroendocrinology, 98(1):16-30.

Goodman RL, Hileman SM, Nestor CC, Porter KL, Connors JM, Hardy SL, Millar RP, Cernea M, Coolen LM, Lehman MN (2013). Kisspeptin, neurokinin B and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes. Endocrinology, 154(11):4259-69.

Van Kesteren FF, Paris M, Macdonald DW, Millar RP, Argaw K, Johnson PJ, Farstad W, Sillero-Zubiri C (2013). The physiology of cooperative breeding in a rare social canid: sex, suppression and pseudopregnancy in female Ethiopian wolves. Physiol Behav, 122C:39-45.

Van Der Goot AC, Dalerum F, Ganswindt A, Martin GB, Millar RP, Paris MCJ (2013) Faecal progestagen profiles in wild southern white rhinoceros (Ceratotherium simum simum). African Zoology, 48, 143-151.

Maione L, Albarel F, Bouchard P, Gallant M, Flanagan CA, Bobe R, Cohen-Tannoudji J, Pivonello R, Colao A, Brue T, Millar RP, Lombes M, Young J, Guiochon-Mantel A, Bouligand J (2013). R31C GnRH1 Mutation and Congenital Hypogonadotropic Hypogonadism. PLoS one, 8:(7) :69616.

Tello JA, Kohout T, Pineda R, Maki RA, Struthers RS, Millar RP (2013). Reproductive physiology of a humanized GnRH receptor mouse model: application in evaluation of human-specific analogs. American Journal of Physiology-Endocrinology and Metabolism, 305, 67-77.

George JT, Veldhuis JD, Tena-Sempere M, Millar RP, Anderson RA (2013). Exploring the Pathophysiology of hyopgonadism in men with type2 diabetes: Kisspeptin-10 stimulates serum testosterone and LH secretion in men with type2 diabetes and mild biochemical hypogonadism. Clinical Endocrinology, 79, 100-104.

Millar RP, Newton CL (2013).Current and future applications of GnRH, kisspeptin and neurokinin B analogues. Nature Reviews Endocrinology, 9, 451-466.

Park CR, Moon MJ, Park S, Kim DK, Cho EB, Millar RP, Hwang JI, Seong JY (2013) A Novel Glucagon-Related Peptide (GCRP) and its Receptor GCRPR account for Coevolution of their family members in vertebrates. PLoS one, 8(6) :65420.

Joseph NT, Tello JA, Bedecarrats GY, Millar RP (2013). Reproductive neuropeptides: Prevalence of GnRH and KNDy neural signalling components in a model avain, gallus gallus. General and Comparative Endocrinology, 1;190:134-43.

Lashkari HP, Nash R, Albanese AA, Okoye B, Millar RP, Pritchard-Jones K (2013). Treatment of high risk Sertoli-Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog. Pediatric Blood & Cancer, 60, 16-18.

Meyer C, Sims AH, Morgan K, Harrison B, Muir MM, Bai JN, Faratian D, Millar RP, Langdon SP, Simon P (2013). Transcript and protein identifies signalling, growth arrest, apoptosis, and NF-kappa B survival signatures following GnRH receptor activation. Endocrine-related cancer, 20:123-136.

De Bond JAP, Li Q, Millar RP, Clarke IJ, Smith JT (2013). Kisspeptin signaling is required for the luteinizing hormone response in Anestrous Ewes following the introduction of Males. PLoS one, 8(2) :57972.

Young J, George JT, Tello JA, Francou B, Bouligand J, Guiochon-Mantel A, Brailly-Tabard S, Anderson RA, Millar RP (2013). Kisspeptin restores pulsatile LH secretion in patients with Neurokinin B signaling deficiencies: Physiological, Pathophysiological and Therapeutic Implications. Neuroendocrinology, 97(2):193-202.

van den Bout I, Halstead JR, Keune W-J, Mohammed S, D’Santos C, Divecha N. (2013) In response to oxidative stress and energy restriction, AMPK and PKC collaborate to induce the phosphorylation of Serine 413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis. Biochemical Journal. 455: 347-358.

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