The Sustainable Development Goals represent a comprehensive and indispensable global agenda with significant implications for all members of society, but most importantly for the well-being of children. Suboptimal child growth and development are highly prevalent in South Africa.

In this address, I will present an overview of my research focusing on the first 1000 days of life – from conception to age two years – a period known to shape the trajectory of lifelong health and well-being. Various factors have emerged in my research as interconnected risk factors for suboptimal fetal growth and postnatal well-being, particularly the impact of maternal HIV infection on her offspring, even when the children themselves remain uninfected.

Additionally, I will explain the pivotal role of placental function on fetal development, particularly its importance in setting the subsequent growth trajectories. Other repercussions of fetal growth restriction encompass stillbirth, perinatal mortality and morbidity and a predisposition to non-communicable diseases in later life. Rooted in these critical first 1000 days, the 'Survive-Thrive-Transform' agenda is pivotal in unlocking each child's genetic potential and contributing towards lifelong health. After explaining the intricate interplay between HIV exposure, placental insufficiency, and socio-economic deprivation as compounding challenges faced by South African children, the presentation will conclude with a description of my current and future research. The focus thereof is on understanding the underlying causes and studying possible interventions to alleviate fetal growth restriction, thereby aligning with the overarching objectives of sustainable development, especially regarding the well-being of vulnerable child populations.

Please click on the button below to RSVP by 4 September 2024.