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Applied Morphology Research Centre (AMRC)

 

Group head: E Pretorius

E-mail: [email protected]

Tel: 012 319 2907

 

Research over the past 5 years:

Over the last 5 years we have established the Applied Morphology Research Centre (AMRC). The aim of the centre was to initiate collaboration between members of the faculty as well as private company initiatives like the SANBS to use morphology to answer critical medical research questions. This has been particularly successful and the focus of the Centre has moved to emphasize the role of platelets, blood cells and coagulation in inflammatory diseases. However, this collaboration effort has since 2010 expanded to include world-renowned research centers where we now have active and ongoing collaboration to study the role of iron in inflammation as well as the possible clinical effects of chelators.

 

Current group members (incl. group head):

Name

Position

Qualification(s)

e-mail address

E Pretorius

 Head: AMRC

PhD

[email protected]

N Oberholzer

Senior lecturer

PhD

[email protected]

M Potgieter

NRF Research Fellow

PhD

[email protected]

Albe Swanepoel

NRF and UP Post-doc

PhD

[email protected]

J Bester

PhD student and Technical assistant

MSc

[email protected]

J du Plooy

PhD Student

MSc

[email protected]

N Vermeulen

NRF Intern

BSc(Hons)

[email protected]

M van Rooy

PhD student and lecturer

MSc

[email protected]

Dr Prashilla Soma

PhD Student and Senior lecturer

MSc

[email protected]

Sajee Alummoottil

PhD student and lecturer

MSc

[email protected]

 

Post-graduate students graduated in the past 5 years:

Name

Degree

Date of qualification

M van der Zeyden

MSc

2009

H Steyn

MSc

2009

Wendy J van der Spuy

MSc

2010 (Cum Laude)

HM  Oberholzer

PhD

2010

M Potgieter

PhD

2010

WA Vieira

MSc

2010 (Cum Laude)

QW Wessels

PhD

2011

J Olivier

MSc

2011

A de Lange

MSc

2011 (Cum Laude)

MJ Engelbrecht

MSc

2011 (Cum Laude)

M van der Walt

MSc

2012

WJ van der Spuy

PhD

2013

AC Swanwpoel

PhD

2013

JN du Plooy

MsC

2013 (Cum Laude)

 

National and international collaborations:

Charlotte Ingram: Haematologist and Medical Director of the SANBS: Resia and the SANBS have had a long-standing relationship where they provide her team with thrombin.  Recently they have started collaborating on Hemochromatosis research. Gerda Fouchê: CSIR – product development.  Resia is testing herbal anti-inflammatory products that the CSIR developed.

B Lipinski: Joslin Diabetes Centre: Harvard: Resia and Boguslaw have shown for the first time the effect of increased iron on platelets, red blood cells and fibrin networks: numerous articles published since 2010: including articles in the high impact journal, Current Drug Targets and BLOOD.

DB Kell: Research Chair in Bioanalytical Science, and Director, Manchester Centre for Integrative Systems Biology, School of Chemistry, and Manchester Institute of Biotechnology, University of Manchester: together with Douglas Kell, Resia has shown that selected chelators may have a protective effect on fibrin networks in the presence of ferric iron.

PV Bernhardt, School of Chemistry and Molecular Biosciences University of Queensland: Paul Bernhardt is a well-known chemist who has recently developed 6 new chelators for possible clinical use.  Resia is currently doing research to determine whether these chelators are as potent as the current leading chelators, (e.g. Desferal).

A Gasparyan, University of Birmingham Together with Armen Gasparyan, we are looking at Lupus and Vasculitis, inflammation and the role of iron in the coagulation process.

E El-Demerdash, Faculty of Pharmacy, Ain Shams University, Egypt: I met Ebhetal El-Demerdash at the AU prize giving ceremony end of 2011, where she won the North African AU women in research prize.  They are starting collaboration where we investigate the role of chelators in the treatment of hepatitis C virus infected individuals.  This will be part of a clinical trial investigation in Egypt.  This research will begin in 2013 and is funded by the SA/Egypt research initiative.

V Nielsen: Arizona University

Jerzy (Yurek) Jankun, D.Sc., Ph.D., Director Urology Research Center, The University of Toledo: Resia, Boguslaw and Yurek are doing research together on iron overload and Yurek provides TEG results in the collaboration.

 

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Last edited by Ansa HeylEdit