Research




Our Research
Several fundamental processes of malaria parasite are poorly understood and our research interest is focused on the physiology, biochemistry and pharmacology of malaria parasites. With a central theme of investigating biochemical distinctions between the malaria parasite and the human host, we aim to exploit these for the design of novel antimalarial chemotherapeuticals. We primarily focused on antimalarials that would target the asexual development of malaria parasites, since such drugs would be useful in the context of malaria prophylaxis or therapy. However, to contribute towards malaria elimination strategies, we are currently also investigating transmitted forms of the parasite (gametocytes) to block transmission between humans and mosquitoes.

 

We employ several strategies including elucidation of drug target structure-activity properties of proteins involved in underexplored metabolic pathways. Additionally, genome-wide investigation of the transcriptome, proteome and metabolome of the parasite after perturbation of these metabolic pathways is employed, allowing explorations of the gene regulatory mechanisms the parasite utilize to control its asexual proliferation in human erythrocytes (read more...)
 
 

 

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