Development of in silico methods to infer immunlogical relationships between proteins with special focus on Cytotoxic T-Cell epitope repertoires

Primary investigator: Dr Werner Smidt

Currently analyzing the different CTL epitope repertoires of HIV and Influenza in the reference of many different HLA allotypes to demonstrate immunological sequestration of certain strains/variants of the pathogens. This could prove useful in studies concerning vaccine design around CTL epitopes. Furthermore, the effect of mutations on immunoevasion that are not necessarily introduced by immune pressure.

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